Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308679564> ?p ?o ?g. }
- W4308679564 abstract "Abstract Paraspeckles are subnuclear RNA–protein structures that are implicated in important processes including cellular stress response, differentiation, and cancer progression. However, it is unclear how paraspeckles impart their physiological effect at the molecular level. Through biochemical analyses, we show that paraspeckles interact with the SWI/SNF chromatin‐remodeling complex. This is specifically mediated by the direct interaction of the long‐non‐coding RNA NEAT1 of the paraspeckles with ARID1B of the cBAF‐type SWI/SNF complex. Strikingly, ARID1B depletion, in addition to resulting in loss of interaction with the SWI/SNF complex, decreases the binding of paraspeckle proteins to chromatin modifiers, transcription factors, and histones. Functionally, the loss of ARID1B and NEAT1 influences the transcription and the alternative splicing of a common set of genes. Our findings reveal that dynamic granules such as the paraspeckles may leverage the specificity of epigenetic modifiers to impart their regulatory effect, thus providing a molecular basis for their function." @default.
- W4308679564 created "2022-11-14" @default.
- W4308679564 creator A5017521861 @default.
- W4308679564 creator A5039663872 @default.
- W4308679564 creator A5042973046 @default.
- W4308679564 creator A5059586165 @default.
- W4308679564 creator A5068374049 @default.
- W4308679564 creator A5069588781 @default.
- W4308679564 creator A5069631252 @default.
- W4308679564 creator A5088793206 @default.
- W4308679564 date "2022-11-10" @default.
- W4308679564 modified "2023-10-08" @default.
- W4308679564 title "Paraspeckles interact with SWI/SNF subunit ARID1B to regulate transcription and splicing" @default.
- W4308679564 cites W1063166136 @default.
- W4308679564 cites W1901046087 @default.
- W4308679564 cites W1969161156 @default.
- W4308679564 cites W1970967363 @default.
- W4308679564 cites W1975283204 @default.
- W4308679564 cites W1981368621 @default.
- W4308679564 cites W1984303280 @default.
- W4308679564 cites W1990299806 @default.
- W4308679564 cites W2008845625 @default.
- W4308679564 cites W2029836146 @default.
- W4308679564 cites W2031073218 @default.
- W4308679564 cites W2031496441 @default.
- W4308679564 cites W2036247643 @default.
- W4308679564 cites W2051282896 @default.
- W4308679564 cites W2052074166 @default.
- W4308679564 cites W2062025099 @default.
- W4308679564 cites W2065701448 @default.
- W4308679564 cites W2066231767 @default.
- W4308679564 cites W2077894744 @default.
- W4308679564 cites W2078138443 @default.
- W4308679564 cites W2091204895 @default.
- W4308679564 cites W2103015533 @default.
- W4308679564 cites W2106488393 @default.
- W4308679564 cites W2106578635 @default.
- W4308679564 cites W2110035824 @default.
- W4308679564 cites W2112094198 @default.
- W4308679564 cites W2112728955 @default.
- W4308679564 cites W2114627554 @default.
- W4308679564 cites W2119079421 @default.
- W4308679564 cites W2122289183 @default.
- W4308679564 cites W2123462814 @default.
- W4308679564 cites W2131445177 @default.
- W4308679564 cites W2132811240 @default.
- W4308679564 cites W2132917776 @default.
- W4308679564 cites W2134476703 @default.
- W4308679564 cites W2140970597 @default.
- W4308679564 cites W2142213527 @default.
- W4308679564 cites W2151537605 @default.
- W4308679564 cites W2160858975 @default.
- W4308679564 cites W2167212154 @default.
- W4308679564 cites W2182963873 @default.
- W4308679564 cites W2216441757 @default.
- W4308679564 cites W2218746042 @default.
- W4308679564 cites W2316020892 @default.
- W4308679564 cites W2340295145 @default.
- W4308679564 cites W2413189460 @default.
- W4308679564 cites W2473064850 @default.
- W4308679564 cites W2473225834 @default.
- W4308679564 cites W2492774354 @default.
- W4308679564 cites W2527576749 @default.
- W4308679564 cites W2569225918 @default.
- W4308679564 cites W2586093186 @default.
- W4308679564 cites W2591968025 @default.
- W4308679564 cites W2604631385 @default.
- W4308679564 cites W2734654523 @default.
- W4308679564 cites W2765488260 @default.
- W4308679564 cites W2781409644 @default.
- W4308679564 cites W2810613916 @default.
- W4308679564 cites W2883234993 @default.
- W4308679564 cites W2884082692 @default.
- W4308679564 cites W2895850607 @default.
- W4308679564 cites W2898224297 @default.
- W4308679564 cites W2900616357 @default.
- W4308679564 cites W2901075549 @default.
- W4308679564 cites W2905266816 @default.
- W4308679564 cites W2934496000 @default.
- W4308679564 cites W2949337802 @default.
- W4308679564 cites W2949778148 @default.
- W4308679564 cites W2951878797 @default.
- W4308679564 cites W2954801177 @default.
- W4308679564 cites W2955282002 @default.
- W4308679564 cites W2971189147 @default.
- W4308679564 cites W2976493974 @default.
- W4308679564 cites W2981555327 @default.
- W4308679564 cites W2981892235 @default.
- W4308679564 cites W2991002790 @default.
- W4308679564 cites W2996607603 @default.
- W4308679564 cites W3004490658 @default.
- W4308679564 cites W3029516223 @default.
- W4308679564 cites W3040465874 @default.
- W4308679564 cites W3041849832 @default.
- W4308679564 cites W3095418010 @default.
- W4308679564 cites W3126694577 @default.
- W4308679564 cites W3134003445 @default.
- W4308679564 cites W3186181848 @default.
- W4308679564 cites W3205771727 @default.
- W4308679564 cites W3213855786 @default.