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• W4308680864 abstract "Dynamic intron retention (IR) in vertebrate cells is of widespread biological importance. Aberrant IR is associated with numerous human diseases including several cancers. Despite consistent reports demonstrating that intrinsic sequence features can help introns evade splicing, conflicting findings about cell type- or condition-specific IR regulation by trans-regulatory and epigenetic mechanisms demand an unbiased and systematic analysis of IR in a controlled experimental setting. We integrated matched mRNA sequencing (mRNA-Seq), whole-genome bisulfite sequencing (WGBS), nucleosome occupancy methylome sequencing (NOMe-Seq) and chromatin immunoprecipitation sequencing (ChIP-Seq) data from primary human myeloid and lymphoid cells. Using these multi-omics data and machine learning, we trained two complementary models to determine the role of epigenetic factors in the regulation of IR in cells of the innate immune system. We show that increased chromatin accessibility, as revealed by nucleosome-free regions, contributes substantially to the retention of introns in a cell-specific manner. We also confirm that intrinsic characteristics of introns are key for them to evade splicing. This study suggests an important role for chromatin architecture in IR regulation. With an increasing appreciation that pathogenic alterations are linked to RNA processing, our findings may provide useful insights for the development of novel therapeutic approaches that target aberrant splicing." @default.
• W4308680864 created "2022-11-14" @default.
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• W4308680864 date "2022-11-10" @default.
• W4308680864 modified "2023-10-11" @default.
• W4308680864 title "Increased chromatin accessibility facilitates intron retention in specific cell differentiation states" @default.
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• W4308680864 cites W1964188377 @default.
• W4308680864 cites W1967064280 @default.
• W4308680864 cites W1968569455 @default.
• W4308680864 cites W1970225064 @default.
• W4308680864 cites W1977151178 @default.
• W4308680864 cites W1981963956 @default.
• W4308680864 cites W1990848127 @default.
• W4308680864 cites W1994288562 @default.
• W4308680864 cites W1997519837 @default.
• W4308680864 cites W2007576179 @default.
• W4308680864 cites W2014108956 @default.
• W4308680864 cites W2034691490 @default.
• W4308680864 cites W2036897871 @default.
• W4308680864 cites W2049022227 @default.
• W4308680864 cites W2049110540 @default.
• W4308680864 cites W2052014424 @default.
• W4308680864 cites W2064372674 @default.
• W4308680864 cites W2070050178 @default.
• W4308680864 cites W2080477348 @default.
• W4308680864 cites W2088338354 @default.
• W4308680864 cites W2097360283 @default.
• W4308680864 cites W2099122564 @default.
• W4308680864 cites W2102619694 @default.
• W4308680864 cites W2111274140 @default.
• W4308680864 cites W2124952135 @default.
• W4308680864 cites W2131374955 @default.
• W4308680864 cites W2141458291 @default.
• W4308680864 cites W2143481518 @default.
• W4308680864 cites W2144015117 @default.
• W4308680864 cites W2146516445 @default.
• W4308680864 cites W2155453721 @default.
• W4308680864 cites W2169456326 @default.
• W4308680864 cites W2171808845 @default.
• W4308680864 cites W2174355534 @default.
• W4308680864 cites W2176036947 @default.
• W4308680864 cites W2177009097 @default.
• W4308680864 cites W2188049916 @default.
• W4308680864 cites W2321832552 @default.
• W4308680864 cites W2331530999 @default.
• W4308680864 cites W2338186631 @default.
• W4308680864 cites W2341539131 @default.
• W4308680864 cites W2342445549 @default.
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• W4308680864 cites W2799383696 @default.
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• W4308680864 cites W2885934659 @default.
• W4308680864 cites W2896364049 @default.
• W4308680864 cites W2900693096 @default.
• W4308680864 cites W2909194804 @default.
• W4308680864 cites W2909466649 @default.
• W4308680864 cites W2949740511 @default.
• W4308680864 cites W2950670315 @default.
• W4308680864 cites W2969538625 @default.
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• W4308680864 doi "https://doi.org/10.1093/nar/gkac994" @default.
• W4308680864 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36354002" @default.
• W4308680864 hasPublicationYear "2022" @default.
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