Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308681256> ?p ?o ?g. }
- W4308681256 endingPage "98" @default.
- W4308681256 startingPage "90" @default.
- W4308681256 abstract "We have previously reported that the dipeptide Phe-Pro affects lipid metabolism in vivo and in vitro, but very little is known regarding the mechanism of action of Phe-Pro after it is absorbed by the intestines via PepT1. In this study, we administered a single oral dose of Phe-Pro to rats and quantified its concentration in the portal plasma using LC-TOF/MS analysis. Additionally, the physiological blood concentration of Phe-Pro was added to the lipid accumulation model of HepG2 cells to decrease intracellular cholesterol and increase the expression of CYP7A1 and PPARα mRNA levels. Moreover, we analyzed the binding of PPARα and Phe-Pro using AlphaFold2. We found that Phe-Pro is a ligand for PPARα. To the best of our knowledge, this is the first study that shows Phe-Pro to be present in the portal plasma. We found for the first time that Phe-Pro ameliorated cholesterol metabolism in HepG2 cells." @default.
- W4308681256 created "2022-11-14" @default.
- W4308681256 creator A5004355274 @default.
- W4308681256 creator A5019336218 @default.
- W4308681256 creator A5047858866 @default.
- W4308681256 creator A5074289815 @default.
- W4308681256 creator A5075017610 @default.
- W4308681256 creator A5077538310 @default.
- W4308681256 creator A5080455602 @default.
- W4308681256 creator A5088081474 @default.
- W4308681256 creator A5089850852 @default.
- W4308681256 date "2022-11-09" @default.
- W4308681256 modified "2023-10-14" @default.
- W4308681256 title "The physiological blood concentration of phenylalanine-proline can ameliorate cholesterol metabolism in HepG2 cells" @default.
- W4308681256 cites W1828402659 @default.
- W4308681256 cites W1988996676 @default.
- W4308681256 cites W1996688175 @default.
- W4308681256 cites W1997901667 @default.
- W4308681256 cites W2018074500 @default.
- W4308681256 cites W2027149291 @default.
- W4308681256 cites W2036555283 @default.
- W4308681256 cites W2037184428 @default.
- W4308681256 cites W2037347330 @default.
- W4308681256 cites W2049485506 @default.
- W4308681256 cites W2052164308 @default.
- W4308681256 cites W2055355331 @default.
- W4308681256 cites W2059221478 @default.
- W4308681256 cites W2059251195 @default.
- W4308681256 cites W2061357909 @default.
- W4308681256 cites W2075882202 @default.
- W4308681256 cites W2081912151 @default.
- W4308681256 cites W2132629607 @default.
- W4308681256 cites W2143165874 @default.
- W4308681256 cites W2167529931 @default.
- W4308681256 cites W2533010365 @default.
- W4308681256 cites W2569874320 @default.
- W4308681256 cites W2786117052 @default.
- W4308681256 cites W2788264780 @default.
- W4308681256 cites W2915978048 @default.
- W4308681256 cites W2949117182 @default.
- W4308681256 cites W2968351635 @default.
- W4308681256 cites W2995858539 @default.
- W4308681256 cites W3001049671 @default.
- W4308681256 cites W3034599671 @default.
- W4308681256 cites W3046581994 @default.
- W4308681256 cites W3046673547 @default.
- W4308681256 cites W3089237281 @default.
- W4308681256 cites W3099669132 @default.
- W4308681256 cites W3164870893 @default.
- W4308681256 cites W3184311036 @default.
- W4308681256 cites W4281790889 @default.
- W4308681256 doi "https://doi.org/10.1093/bbb/zbac167" @default.
- W4308681256 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36352466" @default.
- W4308681256 hasPublicationYear "2022" @default.
- W4308681256 type Work @default.
- W4308681256 citedByCount "0" @default.
- W4308681256 crossrefType "journal-article" @default.
- W4308681256 hasAuthorship W4308681256A5004355274 @default.
- W4308681256 hasAuthorship W4308681256A5019336218 @default.
- W4308681256 hasAuthorship W4308681256A5047858866 @default.
- W4308681256 hasAuthorship W4308681256A5074289815 @default.
- W4308681256 hasAuthorship W4308681256A5075017610 @default.
- W4308681256 hasAuthorship W4308681256A5077538310 @default.
- W4308681256 hasAuthorship W4308681256A5080455602 @default.
- W4308681256 hasAuthorship W4308681256A5088081474 @default.
- W4308681256 hasAuthorship W4308681256A5089850852 @default.
- W4308681256 hasConcept C126322002 @default.
- W4308681256 hasConcept C134018914 @default.
- W4308681256 hasConcept C150903083 @default.
- W4308681256 hasConcept C170493617 @default.
- W4308681256 hasConcept C185592680 @default.
- W4308681256 hasConcept C202751555 @default.
- W4308681256 hasConcept C207001950 @default.
- W4308681256 hasConcept C2777431362 @default.
- W4308681256 hasConcept C2778163477 @default.
- W4308681256 hasConcept C2779138802 @default.
- W4308681256 hasConcept C4733338 @default.
- W4308681256 hasConcept C515207424 @default.
- W4308681256 hasConcept C55493867 @default.
- W4308681256 hasConcept C62231903 @default.
- W4308681256 hasConcept C71924100 @default.
- W4308681256 hasConcept C79879829 @default.
- W4308681256 hasConcept C86803240 @default.
- W4308681256 hasConcept C89673097 @default.
- W4308681256 hasConcept C98274493 @default.
- W4308681256 hasConceptScore W4308681256C126322002 @default.
- W4308681256 hasConceptScore W4308681256C134018914 @default.
- W4308681256 hasConceptScore W4308681256C150903083 @default.
- W4308681256 hasConceptScore W4308681256C170493617 @default.
- W4308681256 hasConceptScore W4308681256C185592680 @default.
- W4308681256 hasConceptScore W4308681256C202751555 @default.
- W4308681256 hasConceptScore W4308681256C207001950 @default.
- W4308681256 hasConceptScore W4308681256C2777431362 @default.
- W4308681256 hasConceptScore W4308681256C2778163477 @default.
- W4308681256 hasConceptScore W4308681256C2779138802 @default.
- W4308681256 hasConceptScore W4308681256C4733338 @default.
- W4308681256 hasConceptScore W4308681256C515207424 @default.
- W4308681256 hasConceptScore W4308681256C55493867 @default.