FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308681937> ?p ?o ?g. }

• W4308681937 endingPage "10648" @default.
• W4308681937 startingPage "10642" @default.
• W4308681937 abstract "The neurological symptoms of long COVID and viral neuroinvasion have raised concerns about the potential interactions between SARS-CoV-2 protein segments and neuronal proteins, which might confer a risk of post-infection neurodegeneration, but the underlying mechanisms remain unclear. Here, we reported that the receptor-binding domain (RBD) of the spike protein and the nine-residue segment (SK9) of the envelope protein could bind to α-synuclein (αSyn) with Kd values of 503 ± 24 nM and 12.7 ± 1.6 μM, respectively. RBD could inhibit αSyn fibrillization by blocking the non-amyloid-β component region and mediating its antiparallel β-sheet structural conversions. Omicron-RBD (BA.5) was shown to have a slightly stronger affinity for αSyn (Kd = 235 ± 10 nM), which implies similar effects, whereas SK9 may bind to the C-terminus which accelerates the formation of parallel β-sheet-containing oligomers and abruptly increases the rate of membrane disruption by 213%. Our results provide plausible molecular insights into the impact of SARS-CoV-2 post-infection and the oligomerization propensity of αSyn that is associated with Parkinson's disease." @default.
• W4308681937 created "2022-11-14" @default.
• W4308681937 creator A5010992487 @default.
• W4308681937 creator A5011146842 @default.
• W4308681937 creator A5020978761 @default.
• W4308681937 creator A5046147086 @default.
• W4308681937 creator A5060813670 @default.
• W4308681937 creator A5074308954 @default.
• W4308681937 creator A5087403063 @default.
• W4308681937 date "2022-11-10" @default.
• W4308681937 modified "2023-10-14" @default.
• W4308681937 title "Moderate Binding between Two SARS-CoV-2 Protein Segments and α-Synuclein Alters Its Toxic Oligomerization Propensity Differently" @default.
• W4308681937 cites W1995191747 @default.
• W4308681937 cites W2025938842 @default.
• W4308681937 cites W2117503265 @default.
• W4308681937 cites W2212998809 @default.
• W4308681937 cites W2266013672 @default.
• W4308681937 cites W2548909731 @default.
• W4308681937 cites W2964896323 @default.
• W4308681937 cites W3013800395 @default.
• W4308681937 cites W3034164977 @default.
• W4308681937 cites W3092499620 @default.
• W4308681937 cites W3095284495 @default.
• W4308681937 cites W3096967708 @default.
• W4308681937 cites W3107007331 @default.
• W4308681937 cites W3110926944 @default.
• W4308681937 cites W3128986841 @default.
• W4308681937 cites W3139126471 @default.
• W4308681937 cites W3152833895 @default.
• W4308681937 cites W3190065470 @default.
• W4308681937 cites W3203433659 @default.
• W4308681937 cites W3215083090 @default.
• W4308681937 cites W4200066927 @default.
• W4308681937 cites W4200311342 @default.
• W4308681937 cites W4206067637 @default.
• W4308681937 cites W4223435260 @default.
• W4308681937 cites W4225489359 @default.
• W4308681937 cites W4280543686 @default.
• W4308681937 cites W4280647001 @default.
• W4308681937 cites W4285987581 @default.
• W4308681937 cites W4293253042 @default.
• W4308681937 doi "https://doi.org/10.1021/acs.jpclett.2c02278" @default.
• W4308681937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36354180" @default.
• W4308681937 hasPublicationYear "2022" @default.
• W4308681937 type Work @default.
• W4308681937 citedByCount "2" @default.
• W4308681937 countsByYear W43086819372023 @default.
• W4308681937 crossrefType "journal-article" @default.
• W4308681937 hasAuthorship W4308681937A5010992487 @default.
• W4308681937 hasAuthorship W4308681937A5011146842 @default.
• W4308681937 hasAuthorship W4308681937A5020978761 @default.
• W4308681937 hasAuthorship W4308681937A5046147086 @default.
• W4308681937 hasAuthorship W4308681937A5060813670 @default.
• W4308681937 hasAuthorship W4308681937A5074308954 @default.
• W4308681937 hasAuthorship W4308681937A5087403063 @default.
• W4308681937 hasBestOaLocation W43086819371 @default.
• W4308681937 hasConcept C115260700 @default.
• W4308681937 hasConcept C121332964 @default.
• W4308681937 hasConcept C12554922 @default.
• W4308681937 hasConcept C142089489 @default.
• W4308681937 hasConcept C142724271 @default.
• W4308681937 hasConcept C185592680 @default.
• W4308681937 hasConcept C2776925932 @default.
• W4308681937 hasConcept C2778815515 @default.
• W4308681937 hasConcept C2779134260 @default.
• W4308681937 hasConcept C2779734285 @default.
• W4308681937 hasConcept C2781449126 @default.
• W4308681937 hasConcept C3007834351 @default.
• W4308681937 hasConcept C3008058167 @default.
• W4308681937 hasConcept C47701112 @default.
• W4308681937 hasConcept C524204448 @default.
• W4308681937 hasConcept C55493867 @default.
• W4308681937 hasConcept C62520636 @default.
• W4308681937 hasConcept C71924100 @default.
• W4308681937 hasConcept C86803240 @default.
• W4308681937 hasConcept C95444343 @default.
• W4308681937 hasConceptScore W4308681937C115260700 @default.
• W4308681937 hasConceptScore W4308681937C121332964 @default.
• W4308681937 hasConceptScore W4308681937C12554922 @default.
• W4308681937 hasConceptScore W4308681937C142089489 @default.
• W4308681937 hasConceptScore W4308681937C142724271 @default.
• W4308681937 hasConceptScore W4308681937C185592680 @default.
• W4308681937 hasConceptScore W4308681937C2776925932 @default.
• W4308681937 hasConceptScore W4308681937C2778815515 @default.
• W4308681937 hasConceptScore W4308681937C2779134260 @default.
• W4308681937 hasConceptScore W4308681937C2779734285 @default.
• W4308681937 hasConceptScore W4308681937C2781449126 @default.
• W4308681937 hasConceptScore W4308681937C3007834351 @default.
• W4308681937 hasConceptScore W4308681937C3008058167 @default.
• W4308681937 hasConceptScore W4308681937C47701112 @default.
• W4308681937 hasConceptScore W4308681937C524204448 @default.
• W4308681937 hasConceptScore W4308681937C55493867 @default.
• W4308681937 hasConceptScore W4308681937C62520636 @default.
• W4308681937 hasConceptScore W4308681937C71924100 @default.
• W4308681937 hasConceptScore W4308681937C86803240 @default.
• W4308681937 hasConceptScore W4308681937C95444343 @default.
• W4308681937 hasFunder F4320321592 @default.
• W4308681937 hasIssue "45" @default.

• next