FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308682719> ?p ?o ?g. }

• W4308682719 endingPage "708" @default.
• W4308682719 startingPage "697" @default.
• W4308682719 abstract "Sjӧgren's syndrome (SS) is an autoimmune inflammatory disease characterized by chronic inflammation and dysfunction of exocrine glands and causes dry mouth, dry eyes and various systemic health problems. The objective of this study is to define the in vivo actions of the endogenous NLRP3 inflammasome, a key initiator and mediator of various immune and inflammatory conditions, in newly established SS disease. MCC950, a highly specific small-molecule inhibitor of NLRP3 inflammasome formation and activation, was intraperitoneally administered to the female non-obese diabetic (NOD) mice aged 11 weeks, which have newly established SS-like hyposalivation and pathologies. The injection was conducted three times weekly for three consecutive weeks and mice were analysed for characteristic SS pathologies at the end of the treatments. MCC950 treatment resulted in a marked reduction in salivary secretion and an exacerbation of leukocyte infiltration of submandibular glands. The disease-worsening effect of MCC950 treatment was accompanied by increased T and B cell numbers, enhanced T helper 1 response and reduced aquaporin 5 expression in submandibular glands. Hence, ablation of endogenous NLRP3 inflammasome activity by MCC950 with established autoimmune exocrinopathy exacerbates salivary gland dysfunction and inflammation, indicating a disease-alleviating and inflammation-dampening action of the endogenous NLRP3 inflammasome activity during established SS disease in the non-obese diabetic mouse model." @default.
• W4308682719 created "2022-11-14" @default.
• W4308682719 creator A5000208362 @default.
• W4308682719 creator A5007980266 @default.
• W4308682719 creator A5018373846 @default.
• W4308682719 date "2022-11-18" @default.
• W4308682719 modified "2023-10-16" @default.
• W4308682719 title "Inhibition of <scp>NLRP3</scp> inflammasome activity by <scp>MCC950</scp> leads to exacerbation of Sjӧgren's syndrome pathologies in non‐obese diabetic mice" @default.
• W4308682719 cites W1510398066 @default.
• W4308682719 cites W1512191677 @default.
• W4308682719 cites W1524794156 @default.
• W4308682719 cites W1541202595 @default.
• W4308682719 cites W1549441204 @default.
• W4308682719 cites W1559677484 @default.
• W4308682719 cites W1562262908 @default.
• W4308682719 cites W1809316277 @default.
• W4308682719 cites W1970895045 @default.
• W4308682719 cites W1971494017 @default.
• W4308682719 cites W1980814242 @default.
• W4308682719 cites W1981052619 @default.
• W4308682719 cites W1984228266 @default.
• W4308682719 cites W1996795990 @default.
• W4308682719 cites W1998055126 @default.
• W4308682719 cites W2004169274 @default.
• W4308682719 cites W2011083985 @default.
• W4308682719 cites W2011438680 @default.
• W4308682719 cites W2017922895 @default.
• W4308682719 cites W2026780425 @default.
• W4308682719 cites W2027638367 @default.
• W4308682719 cites W2033871216 @default.
• W4308682719 cites W2045611996 @default.
• W4308682719 cites W2052460641 @default.
• W4308682719 cites W2053673407 @default.
• W4308682719 cites W2062121752 @default.
• W4308682719 cites W2068100595 @default.
• W4308682719 cites W2078958726 @default.
• W4308682719 cites W2083797943 @default.
• W4308682719 cites W2084925827 @default.
• W4308682719 cites W2094631886 @default.
• W4308682719 cites W2100000086 @default.
• W4308682719 cites W2100878265 @default.
• W4308682719 cites W2104609912 @default.
• W4308682719 cites W2132182228 @default.
• W4308682719 cites W2140637559 @default.
• W4308682719 cites W2168160025 @default.
• W4308682719 cites W2169694612 @default.
• W4308682719 cites W2276338278 @default.
• W4308682719 cites W2320838224 @default.
• W4308682719 cites W2346257082 @default.
• W4308682719 cites W2522054313 @default.
• W4308682719 cites W2562273242 @default.
• W4308682719 cites W2568991061 @default.
• W4308682719 cites W2582624056 @default.
• W4308682719 cites W2604898052 @default.
• W4308682719 cites W2623847043 @default.
• W4308682719 cites W2626074933 @default.
• W4308682719 cites W2737555531 @default.
• W4308682719 cites W2745309325 @default.
• W4308682719 cites W2774045470 @default.
• W4308682719 cites W2779261291 @default.
• W4308682719 cites W2792734340 @default.
• W4308682719 cites W2801925973 @default.
• W4308682719 cites W2806590169 @default.
• W4308682719 cites W2883296062 @default.
• W4308682719 cites W2884445384 @default.
• W4308682719 cites W2911549495 @default.
• W4308682719 cites W2947089396 @default.
• W4308682719 cites W2964003958 @default.
• W4308682719 cites W2982061867 @default.
• W4308682719 doi "https://doi.org/10.1111/imm.13605" @default.
• W4308682719 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36353754" @default.
• W4308682719 hasPublicationYear "2022" @default.
• W4308682719 type Work @default.
• W4308682719 citedByCount "0" @default.
• W4308682719 crossrefType "journal-article" @default.
• W4308682719 hasAuthorship W4308682719A5000208362 @default.
• W4308682719 hasAuthorship W4308682719A5007980266 @default.
• W4308682719 hasAuthorship W4308682719A5018373846 @default.
• W4308682719 hasConcept C126322002 @default.
• W4308682719 hasConcept C134018914 @default.
• W4308682719 hasConcept C159654299 @default.
• W4308682719 hasConcept C16613235 @default.
• W4308682719 hasConcept C203014093 @default.
• W4308682719 hasConcept C2776914184 @default.
• W4308682719 hasConcept C2777014857 @default.
• W4308682719 hasConcept C2777209026 @default.
• W4308682719 hasConcept C2778937882 @default.
• W4308682719 hasConcept C2779075594 @default.
• W4308682719 hasConcept C504460877 @default.
• W4308682719 hasConcept C71924100 @default.
• W4308682719 hasConcept C8891405 @default.
• W4308682719 hasConceptScore W4308682719C126322002 @default.
• W4308682719 hasConceptScore W4308682719C134018914 @default.
• W4308682719 hasConceptScore W4308682719C159654299 @default.
• W4308682719 hasConceptScore W4308682719C16613235 @default.
• W4308682719 hasConceptScore W4308682719C203014093 @default.
• W4308682719 hasConceptScore W4308682719C2776914184 @default.
• W4308682719 hasConceptScore W4308682719C2777014857 @default.

• next