Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308683403> ?p ?o ?g. }
- W4308683403 endingPage "34" @default.
- W4308683403 startingPage "3" @default.
- W4308683403 abstract "The cell nucleus is a complex biological system in which simultaneous reactions and functions take place to keep the cell as an individualized, specialized system running well. The cell nucleus contains chromatin packed in various degrees of density and separated in volumes of chromosome territories and subchromosomal domains. Between the chromatin, however, there is enough “free” space for floating RNA, proteins, enzymes, ATPs, ions, water molecules, etc. which are trafficking by super- and supra-diffusion to the interaction points where they are required. It seems that this trafficking works somehow automatically and drives the system perfectly. After exposure to ionizing radiation causing DNA damage from single base damage up to chromatin double-strand breaks, the whole system “cell nucleus” responds, and repair processes are starting to recover the fully functional and intact system. In molecular biology, many individual epigenetic pathways of DNA damage response or repair of single and double-strand breaks are described. How these responses are embedded into the response of the system as a whole is often out of the focus of consideration. In this article, we want to follow the hypothesis of chromatin architecture’s impact on epigenetic pathways and vice versa. Based on the assumption that chromatin acts like an “aperiodic solid state within a limited volume,” functionally determined networks and local topologies (“islands”) can be defined that drive the appropriate repair process at a given damage site. Experimental results of investigations of the chromatin nano-architecture and DNA repair clusters obtained by means of single-molecule localization microscopy offer hints and perspectives that may contribute to verifying the hypothesis." @default.
- W4308683403 created "2022-11-14" @default.
- W4308683403 creator A5085869876 @default.
- W4308683403 creator A5087475662 @default.
- W4308683403 creator A5091516433 @default.
- W4308683403 date "2022-01-01" @default.
- W4308683403 modified "2023-10-11" @default.
- W4308683403 title "Networks and Islands of Genome Nano-architecture and Their Potential Relevance for Radiation Biology" @default.
- W4308683403 cites W104404459 @default.
- W4308683403 cites W1533778536 @default.
- W4308683403 cites W1752953599 @default.
- W4308683403 cites W1826431536 @default.
- W4308683403 cites W1841331176 @default.
- W4308683403 cites W1931797416 @default.
- W4308683403 cites W1958856311 @default.
- W4308683403 cites W1964951352 @default.
- W4308683403 cites W1967248460 @default.
- W4308683403 cites W1968043437 @default.
- W4308683403 cites W1977145510 @default.
- W4308683403 cites W1979568780 @default.
- W4308683403 cites W1984919526 @default.
- W4308683403 cites W1985363523 @default.
- W4308683403 cites W1985775217 @default.
- W4308683403 cites W1988619801 @default.
- W4308683403 cites W1993558252 @default.
- W4308683403 cites W1994883529 @default.
- W4308683403 cites W1997534905 @default.
- W4308683403 cites W1998592800 @default.
- W4308683403 cites W1999035626 @default.
- W4308683403 cites W2005088616 @default.
- W4308683403 cites W2009576540 @default.
- W4308683403 cites W2012063681 @default.
- W4308683403 cites W2018578705 @default.
- W4308683403 cites W2028138760 @default.
- W4308683403 cites W2028921845 @default.
- W4308683403 cites W2029094445 @default.
- W4308683403 cites W2032725879 @default.
- W4308683403 cites W2036643295 @default.
- W4308683403 cites W2038860354 @default.
- W4308683403 cites W2038932806 @default.
- W4308683403 cites W2040056386 @default.
- W4308683403 cites W2041105606 @default.
- W4308683403 cites W2041977470 @default.
- W4308683403 cites W2045526190 @default.
- W4308683403 cites W2049738661 @default.
- W4308683403 cites W2051193631 @default.
- W4308683403 cites W2051950507 @default.
- W4308683403 cites W2053016947 @default.
- W4308683403 cites W2053417989 @default.
- W4308683403 cites W2053549853 @default.
- W4308683403 cites W2054422175 @default.
- W4308683403 cites W2055725338 @default.
- W4308683403 cites W2070021921 @default.
- W4308683403 cites W2071175902 @default.
- W4308683403 cites W2071225793 @default.
- W4308683403 cites W2071391326 @default.
- W4308683403 cites W2071457560 @default.
- W4308683403 cites W2073026107 @default.
- W4308683403 cites W2074779681 @default.
- W4308683403 cites W2080313089 @default.
- W4308683403 cites W2080615813 @default.
- W4308683403 cites W2080666790 @default.
- W4308683403 cites W2082749639 @default.
- W4308683403 cites W2090037139 @default.
- W4308683403 cites W2090632681 @default.
- W4308683403 cites W2090746166 @default.
- W4308683403 cites W2090854519 @default.
- W4308683403 cites W2090860493 @default.
- W4308683403 cites W2094727846 @default.
- W4308683403 cites W2095265341 @default.
- W4308683403 cites W2097027640 @default.
- W4308683403 cites W2099077495 @default.
- W4308683403 cites W2103007290 @default.
- W4308683403 cites W2104128454 @default.
- W4308683403 cites W2105185962 @default.
- W4308683403 cites W2110979604 @default.
- W4308683403 cites W2111337030 @default.
- W4308683403 cites W2116302199 @default.
- W4308683403 cites W2117591057 @default.
- W4308683403 cites W2118670247 @default.
- W4308683403 cites W2121070277 @default.
- W4308683403 cites W2123241821 @default.
- W4308683403 cites W2132794930 @default.
- W4308683403 cites W2134807701 @default.
- W4308683403 cites W2155318349 @default.
- W4308683403 cites W2155859779 @default.
- W4308683403 cites W2157899948 @default.
- W4308683403 cites W2158099110 @default.
- W4308683403 cites W2164995160 @default.
- W4308683403 cites W2165267362 @default.
- W4308683403 cites W2217722934 @default.
- W4308683403 cites W2310049852 @default.
- W4308683403 cites W2326176611 @default.
- W4308683403 cites W2336105423 @default.
- W4308683403 cites W2394483225 @default.
- W4308683403 cites W2418736231 @default.
- W4308683403 cites W2517930764 @default.
- W4308683403 cites W2561960585 @default.