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- W4308684438 abstract "Significance: Increased plasma concentrations of total homocysteine (tHcy; mild-moderate hyperhomocysteinemia: 15-50 μM tHcy) are considered an independent risk factor for the onset/progression of various diseases, but it is not known about how the increase in tHcy causes pathological conditions. Recent Advances: Reduced homocysteine (HSH ∼1% of tHcy) is presumed to be toxic, unlike homocystine (∼9%) and mixed disulfide between homocysteine and albumin (HSS-ALB; homocysteine [Hcy]-albumin mixed disulfide, ∼90%). This and other notions make it difficult to explain the pathogenicity of Hcy because: (i) lowering tHcy does not improve pathological outcomes; (ii) damage due to HSH usually emerges at supraphysiological doses; and (iii) it is not known why tiny increments in plasma concentrations of HSH can be pathological. Critical Issues: Albumin may have a role in Hcy toxicity, because HSS-ALB could release toxic HSH via thiol-disulfide (SH/SS) exchange reactions in cells. Similarly, thiol-disulfide exchange processes of reduced albumin (albumin with free SH group of Cys34 [HS-ALB]) or N-homocysteinylated albumin are plausible alternatives for initiating Hcy pathological events. Adverse effects of albumin and other data reviewed here suggest the hypothesis of a role of albumin in Hcy toxicity. Future Directions: HSS-ALB might be involved in disruption of the antioxidant/oxidant balance in critical tissues (brain, liver, kidney). Since homocysteine-albumin mixed disulfide is a possible intermediate of thiol-disulfide exchange reactions, we suggest that homocysteinylated albumin could be a new pathological factor, and that studies on the redox role of albumin and mixed disulfide production via thiol-disulfide exchange reactions could offer new therapeutic insights for reducing Hcy toxicity." @default.
- W4308684438 created "2022-11-14" @default.
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- W4308684438 date "2023-03-03" @default.
- W4308684438 modified "2023-10-01" @default.
- W4308684438 title "Does Risk of Hyperhomocysteinemia Depend on Thiol-Disulfide Exchange Reactions of Albumin and Homocysteine?" @default.
- W4308684438 cites W103959752 @default.
- W4308684438 cites W1500962797 @default.
- W4308684438 cites W1504792186 @default.
- W4308684438 cites W1528442160 @default.
- W4308684438 cites W1547957565 @default.
- W4308684438 cites W1549273904 @default.
- W4308684438 cites W1557154008 @default.
- W4308684438 cites W1559258409 @default.
- W4308684438 cites W1571018405 @default.
- W4308684438 cites W1575542562 @default.
- W4308684438 cites W1577460613 @default.
- W4308684438 cites W1581616514 @default.
- W4308684438 cites W1583601846 @default.
- W4308684438 cites W1592584230 @default.
- W4308684438 cites W1604116800 @default.
- W4308684438 cites W1719708418 @default.
- W4308684438 cites W1823480916 @default.
- W4308684438 cites W1832050014 @default.
- W4308684438 cites W1916826630 @default.
- W4308684438 cites W1929386789 @default.
- W4308684438 cites W1964147141 @default.
- W4308684438 cites W1965534800 @default.
- W4308684438 cites W1967874097 @default.
- W4308684438 cites W1967960010 @default.
- W4308684438 cites W1968216888 @default.
- W4308684438 cites W1968300672 @default.
- W4308684438 cites W1968367779 @default.
- W4308684438 cites W1968382122 @default.
- W4308684438 cites W1968418371 @default.
- W4308684438 cites W1969338661 @default.
- W4308684438 cites W1970584787 @default.
- W4308684438 cites W1973238993 @default.
- W4308684438 cites W1973592942 @default.
- W4308684438 cites W1973788406 @default.
- W4308684438 cites W1974943937 @default.
- W4308684438 cites W1975357252 @default.
- W4308684438 cites W1975586699 @default.
- W4308684438 cites W1977669756 @default.
- W4308684438 cites W1978796955 @default.
- W4308684438 cites W1978853745 @default.
- W4308684438 cites W1980078657 @default.
- W4308684438 cites W1981361599 @default.
- W4308684438 cites W1982040136 @default.
- W4308684438 cites W1982060886 @default.
- W4308684438 cites W1982341626 @default.
- W4308684438 cites W1982613368 @default.
- W4308684438 cites W1984049469 @default.
- W4308684438 cites W1984620545 @default.
- W4308684438 cites W1985604220 @default.
- W4308684438 cites W1987095957 @default.
- W4308684438 cites W1987991433 @default.
- W4308684438 cites W1989045342 @default.
- W4308684438 cites W1989458910 @default.
- W4308684438 cites W1989929999 @default.
- W4308684438 cites W1989990107 @default.
- W4308684438 cites W1991091655 @default.
- W4308684438 cites W1991941799 @default.
- W4308684438 cites W1992098105 @default.
- W4308684438 cites W1992883702 @default.
- W4308684438 cites W1995037165 @default.
- W4308684438 cites W1995370236 @default.
- W4308684438 cites W1995666127 @default.
- W4308684438 cites W1995736055 @default.
- W4308684438 cites W1995931698 @default.
- W4308684438 cites W1996253830 @default.
- W4308684438 cites W1996584317 @default.
- W4308684438 cites W1998029664 @default.
- W4308684438 cites W1998292095 @default.
- W4308684438 cites W1998439395 @default.
- W4308684438 cites W1999265250 @default.
- W4308684438 cites W2001327603 @default.
- W4308684438 cites W2002167559 @default.
- W4308684438 cites W2002507728 @default.
- W4308684438 cites W2003659035 @default.
- W4308684438 cites W2005072188 @default.
- W4308684438 cites W2006239204 @default.
- W4308684438 cites W2007217012 @default.
- W4308684438 cites W2007426167 @default.
- W4308684438 cites W2008232785 @default.
- W4308684438 cites W2008424444 @default.
- W4308684438 cites W2008834586 @default.
- W4308684438 cites W2009304280 @default.
- W4308684438 cites W2009331130 @default.
- W4308684438 cites W2009842820 @default.
- W4308684438 cites W2009917982 @default.