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- W4308685416 abstract "Elafin and its precursor trappin-2 are known for their contribution to the physiological mucosal shield against luminal microbes. Such a contribution seems to be particularly relevant in the gut, where the exposure of host tissues to heavy loads of microbes is constant and contributes to mucosa-associated pathologies. The expression of trappin-2/elafin has been shown to be differentially regulated in diseases associated with gut inflammation. Accumulating evidence has demonstrated the protective effects of trappin-2/elafin in gut intestinal disorders associated with acute or chronic inflammation, or with gluten sensitization disorders. The protective effects of trappin-2/elafin in the gut are discussed in terms of their pleiotropic modes of action: acting as protease inhibitors, transglutaminase substrates, antimicrobial peptides or as a regulator of pro-inflammatory transcription factors. Further, the question of the therapeutic potential of trappin-2/elafin delivery at the intestinal mucosa surface is raised. Whether trappin-2/elafin mucosal delivery should be considered to ensure intestinal tissue repair is also discussed." @default.
- W4308685416 created "2022-11-14" @default.
- W4308685416 creator A5017330197 @default.
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- W4308685416 creator A5034119776 @default.
- W4308685416 creator A5038560460 @default.
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- W4308685416 date "2022-11-28" @default.
- W4308685416 modified "2023-09-30" @default.
- W4308685416 title "Elafin and its precursor trappin‐2: What is their therapeutic potential for intestinal diseases?" @default.
- W4308685416 cites W1515798545 @default.
- W4308685416 cites W1531471821 @default.
- W4308685416 cites W1572100679 @default.
- W4308685416 cites W1599057242 @default.
- W4308685416 cites W1627442108 @default.
- W4308685416 cites W1795031534 @default.
- W4308685416 cites W1817751341 @default.
- W4308685416 cites W1841109932 @default.
- W4308685416 cites W1845467274 @default.
- W4308685416 cites W1849505552 @default.
- W4308685416 cites W1896141452 @default.
- W4308685416 cites W1942121673 @default.
- W4308685416 cites W1956494115 @default.
- W4308685416 cites W1963982200 @default.
- W4308685416 cites W1966774641 @default.
- W4308685416 cites W1973752319 @default.
- W4308685416 cites W1974972022 @default.
- W4308685416 cites W1975441923 @default.
- W4308685416 cites W1976241937 @default.
- W4308685416 cites W1978007043 @default.
- W4308685416 cites W1979687908 @default.
- W4308685416 cites W1979858563 @default.
- W4308685416 cites W1980242851 @default.
- W4308685416 cites W1981419554 @default.
- W4308685416 cites W1996475963 @default.
- W4308685416 cites W1999420207 @default.
- W4308685416 cites W2001893139 @default.
- W4308685416 cites W2002570028 @default.
- W4308685416 cites W2003375281 @default.
- W4308685416 cites W2010412209 @default.
- W4308685416 cites W2010704116 @default.
- W4308685416 cites W2011072279 @default.
- W4308685416 cites W2015939473 @default.
- W4308685416 cites W2022407205 @default.
- W4308685416 cites W2022976745 @default.
- W4308685416 cites W2024249553 @default.
- W4308685416 cites W2034056147 @default.
- W4308685416 cites W2036001173 @default.
- W4308685416 cites W2041243632 @default.
- W4308685416 cites W2045145961 @default.
- W4308685416 cites W2045915987 @default.
- W4308685416 cites W2048209972 @default.
- W4308685416 cites W2048360369 @default.
- W4308685416 cites W2052257525 @default.
- W4308685416 cites W2054724293 @default.
- W4308685416 cites W2056478385 @default.
- W4308685416 cites W2057355956 @default.
- W4308685416 cites W2061766973 @default.
- W4308685416 cites W2062859142 @default.
- W4308685416 cites W2076765482 @default.
- W4308685416 cites W2081619583 @default.
- W4308685416 cites W2086657607 @default.
- W4308685416 cites W2091278724 @default.
- W4308685416 cites W2091587044 @default.
- W4308685416 cites W2095239148 @default.
- W4308685416 cites W2100679326 @default.
- W4308685416 cites W2102943702 @default.
- W4308685416 cites W2104310011 @default.
- W4308685416 cites W2112383838 @default.
- W4308685416 cites W2119364523 @default.
- W4308685416 cites W2122332977 @default.
- W4308685416 cites W2123579792 @default.
- W4308685416 cites W2127332380 @default.
- W4308685416 cites W2128549250 @default.
- W4308685416 cites W2136908993 @default.
- W4308685416 cites W2137687020 @default.
- W4308685416 cites W2146353544 @default.
- W4308685416 cites W2147969650 @default.
- W4308685416 cites W2148582470 @default.
- W4308685416 cites W2148732844 @default.
- W4308685416 cites W2150661557 @default.
- W4308685416 cites W2156288459 @default.
- W4308685416 cites W2162118074 @default.
- W4308685416 cites W2162869700 @default.
- W4308685416 cites W2163008723 @default.
- W4308685416 cites W2166839330 @default.
- W4308685416 cites W2166990719 @default.
- W4308685416 cites W2170260537 @default.
- W4308685416 cites W2273234143 @default.
- W4308685416 cites W2331857781 @default.
- W4308685416 cites W2335993428 @default.
- W4308685416 cites W2460175854 @default.
- W4308685416 cites W2586229256 @default.
- W4308685416 cites W2766468572 @default.
- W4308685416 cites W2801734622 @default.
- W4308685416 cites W2898812156 @default.
- W4308685416 cites W2911424501 @default.
- W4308685416 cites W2912663500 @default.