FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308686075> ?p ?o ?g. }

• W4308686075 endingPage "389" @default.
• W4308686075 startingPage "378" @default.
• W4308686075 abstract "The claustrum has long been regarded as a vital center for conscious control. Electrical stimulation or damage to the claustrum can result in decreased awareness or loss of consciousness, suggesting that the claustrum may be a target for the action of general anesthetics. This study aimed to determine the role of the claustrum in propofol anesthesia.We first applied a fiber photometry calcium signal recording system to record the claustral neuronal activity during the entire process of propofol anesthesia. Chemogenetic activation of claustral neurones was then performed to verify their role in anesthesia. Finally, muscimol (GABAa receptor agonist) and gabazine (GABAa receptor antagonist) were microinjected into the claustrum to determine whether their GABAa receptors were involved in modulating propofol anesthesia. EEG and behavioral indicators, such as anesthetic sensitivity and efficacy, were recorded and analyzed.An evident anesthesia-related change in claustrum neuronal activity was suppressed during propofol-induced unconsciousness and restored following recovery from anesthesia. Chemogenetic activation of claustrum neurons results in attenuated propofol sensitivity, a shorter anesthesia duration, and an EEG shift toward wakefulness. Manipulation of GABAa receptors in the claustrum showed bidirectional control of propofol sensitivity, as activation decreases anesthesia efficiency while inactivation augments it. Additionally, inhibiting claustrum GABAa receptors increases cortical EEG slow waves.Claustrum neurones and their GABAa receptors are implicated in the modulation of propofol anesthesia in both behavioral and EEG assessments. Our findings create scope to reveal the brain targets of anesthetic action further and add to the existing evidence on the consciousness-modulating role of the claustrum." @default.
• W4308686075 created "2022-11-14" @default.
• W4308686075 creator A5017774638 @default.
• W4308686075 creator A5021541475 @default.
• W4308686075 creator A5029928683 @default.
• W4308686075 creator A5055115466 @default.
• W4308686075 creator A5057301699 @default.
• W4308686075 creator A5058554865 @default.
• W4308686075 creator A5076256049 @default.
• W4308686075 creator A5077712360 @default.
• W4308686075 date "2022-11-09" @default.
• W4308686075 modified "2023-10-12" @default.
• W4308686075 title "Claustrum modulates behavioral sensitivity and <scp>EEG</scp> activity of propofol anesthesia" @default.
• W4308686075 cites W103540227 @default.
• W4308686075 cites W1821353301 @default.
• W4308686075 cites W1863427091 @default.
• W4308686075 cites W1972473633 @default.
• W4308686075 cites W1980380964 @default.
• W4308686075 cites W2001908985 @default.
• W4308686075 cites W2020491332 @default.
• W4308686075 cites W2038708048 @default.
• W4308686075 cites W2050375359 @default.
• W4308686075 cites W2120315474 @default.
• W4308686075 cites W2121148760 @default.
• W4308686075 cites W2124969467 @default.
• W4308686075 cites W2143703862 @default.
• W4308686075 cites W2147595049 @default.
• W4308686075 cites W2154569857 @default.
• W4308686075 cites W2159423326 @default.
• W4308686075 cites W2168399910 @default.
• W4308686075 cites W2471626793 @default.
• W4308686075 cites W2527813509 @default.
• W4308686075 cites W2530703593 @default.
• W4308686075 cites W2572968787 @default.
• W4308686075 cites W2591058653 @default.
• W4308686075 cites W2610213115 @default.
• W4308686075 cites W2766132918 @default.
• W4308686075 cites W2787216349 @default.
• W4308686075 cites W2902015781 @default.
• W4308686075 cites W2934171181 @default.
• W4308686075 cites W2947596811 @default.
• W4308686075 cites W2948725706 @default.
• W4308686075 cites W2950944353 @default.
• W4308686075 cites W2985093375 @default.
• W4308686075 cites W3000742011 @default.
• W4308686075 cites W3023510342 @default.
• W4308686075 cites W3082364846 @default.
• W4308686075 cites W3095827318 @default.
• W4308686075 cites W3102943342 @default.
• W4308686075 cites W3135349406 @default.
• W4308686075 cites W3159347088 @default.
• W4308686075 cites W4206222539 @default.
• W4308686075 cites W4220703398 @default.
• W4308686075 cites W4220970541 @default.
• W4308686075 cites W4308686075 @default.
• W4308686075 cites W870539061 @default.
• W4308686075 doi "https://doi.org/10.1111/cns.14012" @default.
• W4308686075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36353753" @default.
• W4308686075 hasPublicationYear "2022" @default.
• W4308686075 type Work @default.
• W4308686075 citedByCount "1" @default.
• W4308686075 countsByYear W43086860752022 @default.
• W4308686075 crossrefType "journal-article" @default.
• W4308686075 hasAuthorship W4308686075A5017774638 @default.
• W4308686075 hasAuthorship W4308686075A5021541475 @default.
• W4308686075 hasAuthorship W4308686075A5029928683 @default.
• W4308686075 hasAuthorship W4308686075A5055115466 @default.
• W4308686075 hasAuthorship W4308686075A5057301699 @default.
• W4308686075 hasAuthorship W4308686075A5058554865 @default.
• W4308686075 hasAuthorship W4308686075A5076256049 @default.
• W4308686075 hasAuthorship W4308686075A5077712360 @default.
• W4308686075 hasBestOaLocation W43086860751 @default.
• W4308686075 hasConcept C126322002 @default.
• W4308686075 hasConcept C15744967 @default.
• W4308686075 hasConcept C168258287 @default.
• W4308686075 hasConcept C169760540 @default.
• W4308686075 hasConcept C170493617 @default.
• W4308686075 hasConcept C2776277131 @default.
• W4308686075 hasConcept C2778162923 @default.
• W4308686075 hasConcept C2778409475 @default.
• W4308686075 hasConcept C2779188335 @default.
• W4308686075 hasConcept C2779920484 @default.
• W4308686075 hasConcept C2780723820 @default.
• W4308686075 hasConcept C2780763569 @default.
• W4308686075 hasConcept C42219234 @default.
• W4308686075 hasConcept C71924100 @default.
• W4308686075 hasConcept C98274493 @default.
• W4308686075 hasConceptScore W4308686075C126322002 @default.
• W4308686075 hasConceptScore W4308686075C15744967 @default.
• W4308686075 hasConceptScore W4308686075C168258287 @default.
• W4308686075 hasConceptScore W4308686075C169760540 @default.
• W4308686075 hasConceptScore W4308686075C170493617 @default.
• W4308686075 hasConceptScore W4308686075C2776277131 @default.
• W4308686075 hasConceptScore W4308686075C2778162923 @default.
• W4308686075 hasConceptScore W4308686075C2778409475 @default.
• W4308686075 hasConceptScore W4308686075C2779188335 @default.
• W4308686075 hasConceptScore W4308686075C2779920484 @default.
• W4308686075 hasConceptScore W4308686075C2780723820 @default.

• next