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- W4308686286 abstract "The assembly of adenosine triphosphate (ATP)-responsive and miRNA-responsive DNA tetrahedra-functionalized carboxymethyl cellulose hydrogel microcapsules is presented. The microcapsules are loaded with the doxorubicin-dextran drug or with CdSe/ZnS quantum dots as a drug model. Selective unlocking of the respective microcapsules and the release of the loads in the presence of ATP or miRNA-141 are demonstrated. Functionalization of the hydrogel microcapsules a with corona of DNA tetrahedra nanostructures yields microcarriers that revealed superior permeation into cells. This is demonstrated by the effective permeation of the DNA tetrahedra-functionalized microcapsules into MDA-MB-231 breast cancer cells, as compared to epithelial MCF-10A nonmalignant breast cells. The superior permeation of the tetrahedra-functionalized microcapsules into MDA-MB-231 breast cancer cells, as compared to analog control hydrogel microcapsules modified with a corona of nucleic acid duplexes. The effective permeation of the stimuli-responsive, drug-loaded, DNA tetrahedra-modified microcapsules yields drug carriers of superior and selective cytotoxicity toward cancer cells." @default.
- W4308686286 created "2022-11-14" @default.
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- W4308686286 date "2022-11-09" @default.
- W4308686286 modified "2023-10-12" @default.
- W4308686286 title "DNA‐Tetrahedra Corona‐Modified Hydrogel Microcapsules: “Smart” ATP‐ or microRNA‐Responsive Drug Carriers" @default.
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- W4308686286 doi "https://doi.org/10.1002/smll.202204108" @default.
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