Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308686324> ?p ?o ?g. }
- W4308686324 endingPage "311" @default.
- W4308686324 startingPage "295" @default.
- W4308686324 abstract "Sperm nuclei present a highly organized and condensed chromatin due to the interchange of histones by protamines during spermiogenesis. This high DNA condensation leads to almost inert chromatin, with the impossibility of conducting gene transcription as in most other somatic cells. The major chromosomal structure responsible for DNA condensation is the formation of protamine-DNA toroids containing 25-50 kilobases of DNA. These toroids are connected by toroid linker regions (TLR), which attach them to the nuclear matrix, as matrix attachment regions (MAR) do in somatic cells. Despite this high degree of condensation, evidence shows that sperm chromatin contains vulnerable elements that can be degraded even in fully condensed chromatin, which may correspond to chromatin regions that transfer functionality to the zygote at fertilization. This chapter covers an updated review of our model for sperm chromatin structure and its potential functional elements that affect embryo development." @default.
- W4308686324 created "2022-11-14" @default.
- W4308686324 creator A5035117569 @default.
- W4308686324 creator A5054171294 @default.
- W4308686324 creator A5078694940 @default.
- W4308686324 creator A5089949152 @default.
- W4308686324 date "2022-01-01" @default.
- W4308686324 modified "2023-10-05" @default.
- W4308686324 title "Functional Aspects of Sperm Chromatin Organization" @default.
- W4308686324 cites W1736102530 @default.
- W4308686324 cites W1835059569 @default.
- W4308686324 cites W1949465845 @default.
- W4308686324 cites W1963895341 @default.
- W4308686324 cites W1966778286 @default.
- W4308686324 cites W1969433941 @default.
- W4308686324 cites W1980426213 @default.
- W4308686324 cites W1982674658 @default.
- W4308686324 cites W1991136563 @default.
- W4308686324 cites W1991720664 @default.
- W4308686324 cites W1992770121 @default.
- W4308686324 cites W1993481243 @default.
- W4308686324 cites W1997632403 @default.
- W4308686324 cites W1998425565 @default.
- W4308686324 cites W1998773767 @default.
- W4308686324 cites W2006866503 @default.
- W4308686324 cites W2010980471 @default.
- W4308686324 cites W2013214437 @default.
- W4308686324 cites W2016733318 @default.
- W4308686324 cites W2019296561 @default.
- W4308686324 cites W2020118100 @default.
- W4308686324 cites W2027192099 @default.
- W4308686324 cites W2028029982 @default.
- W4308686324 cites W2030622242 @default.
- W4308686324 cites W2030937434 @default.
- W4308686324 cites W2031192550 @default.
- W4308686324 cites W2033965642 @default.
- W4308686324 cites W2037818631 @default.
- W4308686324 cites W2037863817 @default.
- W4308686324 cites W2038750377 @default.
- W4308686324 cites W2046874889 @default.
- W4308686324 cites W2051854412 @default.
- W4308686324 cites W2052948676 @default.
- W4308686324 cites W2057092823 @default.
- W4308686324 cites W2057691360 @default.
- W4308686324 cites W2058438535 @default.
- W4308686324 cites W2060386232 @default.
- W4308686324 cites W2061974398 @default.
- W4308686324 cites W2062382797 @default.
- W4308686324 cites W2064038012 @default.
- W4308686324 cites W2064537118 @default.
- W4308686324 cites W2072697652 @default.
- W4308686324 cites W2081114467 @default.
- W4308686324 cites W2082489526 @default.
- W4308686324 cites W2084765400 @default.
- W4308686324 cites W2085296038 @default.
- W4308686324 cites W2090252321 @default.
- W4308686324 cites W2097337492 @default.
- W4308686324 cites W2097798808 @default.
- W4308686324 cites W2103336074 @default.
- W4308686324 cites W2115375521 @default.
- W4308686324 cites W2117016728 @default.
- W4308686324 cites W2118052320 @default.
- W4308686324 cites W2118139080 @default.
- W4308686324 cites W2120367862 @default.
- W4308686324 cites W2120504470 @default.
- W4308686324 cites W2124593776 @default.
- W4308686324 cites W2125098120 @default.
- W4308686324 cites W2126608167 @default.
- W4308686324 cites W2126676615 @default.
- W4308686324 cites W2127043939 @default.
- W4308686324 cites W2129691498 @default.
- W4308686324 cites W2130732086 @default.
- W4308686324 cites W2130943978 @default.
- W4308686324 cites W2131449314 @default.
- W4308686324 cites W2134981755 @default.
- W4308686324 cites W2138655345 @default.
- W4308686324 cites W2138760938 @default.
- W4308686324 cites W2144792857 @default.
- W4308686324 cites W2146990851 @default.
- W4308686324 cites W2149688232 @default.
- W4308686324 cites W2151372165 @default.
- W4308686324 cites W2153621755 @default.
- W4308686324 cites W2158593512 @default.
- W4308686324 cites W2161522517 @default.
- W4308686324 cites W2162644145 @default.
- W4308686324 cites W2289556065 @default.
- W4308686324 cites W2513644890 @default.
- W4308686324 cites W2587651673 @default.
- W4308686324 cites W2797658674 @default.
- W4308686324 cites W2800816467 @default.
- W4308686324 cites W2803274958 @default.
- W4308686324 cites W2811305487 @default.
- W4308686324 cites W2891519606 @default.
- W4308686324 cites W2898577086 @default.
- W4308686324 cites W2913502276 @default.
- W4308686324 cites W2915505354 @default.
- W4308686324 cites W2944342742 @default.
- W4308686324 cites W2944584202 @default.