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- W4308686508 abstract "Inflammation is a common feature in neurodegenerative diseases that contributes to neuronal loss. Previously, we demonstrated that the basal inflammatory tone differed between brain regions and, consequently, the reaction generated to a pro-inflammatory stimulus was different. In this study, we assessed the innate immune reaction in the midbrain and in the striatum using an experimental model of Parkinson's disease. An adeno-associated virus serotype 9 expressing the α-synuclein and mCherry genes or the mCherry gene was administered into the substantia nigra. Myeloid cells (CD11b+ ) and astrocytes (ACSA2+ ) were purified from the midbrain and striatum for bulk RNA sequencing. In the parkinsonian midbrain, CD11b+ cells presented a unique anti-inflammatory transcriptomic profile that differed from degenerative microglia signatures described in experimental models for other neurodegenerative conditions. By contrast, striatal CD11b+ cells showed a pro-inflammatory state and were similar to disease-associated microglia. In the midbrain, a prominent increase of infiltrated monocytes/macrophages was observed and, together with microglia, participated actively in the phagocytosis of dopaminergic neuronal bodies. Although striatal microglia presented a phagocytic transcriptomic profile, morphology and cell density was preserved and no active phagocytosis was detected. Interestingly, astrocytes presented a pro-inflammatory fingerprint in the midbrain and a low number of differentially displayed transcripts in the striatum. During α-synuclein-dependent degeneration, microglia and astrocytes experience context-dependent activation states with a different contribution to the inflammatory reaction. Our results point towards the relevance of selecting appropriate cell targets to design neuroprotective strategies aimed to modulate the innate immune system during the active phase of dopaminergic degeneration." @default.
- W4308686508 created "2022-11-14" @default.
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- W4308686508 date "2022-11-10" @default.
- W4308686508 modified "2023-10-17" @default.
- W4308686508 title "Microglia and astrocyte activation is region‐dependent in the α‐synuclein mouse model of Parkinson's disease" @default.
- W4308686508 cites W1594747697 @default.
- W4308686508 cites W1608593799 @default.
- W4308686508 cites W1965778124 @default.
- W4308686508 cites W1966918485 @default.
- W4308686508 cites W1967640115 @default.
- W4308686508 cites W1973756832 @default.
- W4308686508 cites W1974924674 @default.
- W4308686508 cites W1975331070 @default.
- W4308686508 cites W1996706043 @default.
- W4308686508 cites W2005356215 @default.
- W4308686508 cites W2010395737 @default.
- W4308686508 cites W2010612415 @default.
- W4308686508 cites W2011719513 @default.
- W4308686508 cites W2019863741 @default.
- W4308686508 cites W2020541351 @default.
- W4308686508 cites W2041785681 @default.
- W4308686508 cites W2044037509 @default.
- W4308686508 cites W2047402578 @default.
- W4308686508 cites W2051159468 @default.
- W4308686508 cites W2052770514 @default.
- W4308686508 cites W2058092975 @default.
- W4308686508 cites W2058669152 @default.
- W4308686508 cites W2060678482 @default.
- W4308686508 cites W2065422132 @default.
- W4308686508 cites W2068929145 @default.
- W4308686508 cites W2071010503 @default.
- W4308686508 cites W2084566588 @default.
- W4308686508 cites W2089054536 @default.
- W4308686508 cites W2090409342 @default.
- W4308686508 cites W2095444837 @default.
- W4308686508 cites W2095474336 @default.
- W4308686508 cites W2103738800 @default.
- W4308686508 cites W2106705545 @default.
- W4308686508 cites W2112111711 @default.
- W4308686508 cites W2114172247 @default.
- W4308686508 cites W2117442313 @default.
- W4308686508 cites W2128631317 @default.
- W4308686508 cites W2137829901 @default.
- W4308686508 cites W2141459724 @default.
- W4308686508 cites W2146921697 @default.
- W4308686508 cites W2148726772 @default.
- W4308686508 cites W2150656456 @default.
- W4308686508 cites W2151513507 @default.
- W4308686508 cites W2156679081 @default.
- W4308686508 cites W2163743819 @default.
- W4308686508 cites W2165465283 @default.
- W4308686508 cites W2176154815 @default.
- W4308686508 cites W2261364877 @default.
- W4308686508 cites W2280077905 @default.
- W4308686508 cites W2312699105 @default.
- W4308686508 cites W2327803761 @default.
- W4308686508 cites W2559702793 @default.
- W4308686508 cites W2560668196 @default.
- W4308686508 cites W2565786983 @default.
- W4308686508 cites W2565958526 @default.
- W4308686508 cites W2572710398 @default.
- W4308686508 cites W2610699844 @default.
- W4308686508 cites W2611596972 @default.
- W4308686508 cites W2622807556 @default.
- W4308686508 cites W2735769265 @default.
- W4308686508 cites W2754890392 @default.
- W4308686508 cites W2755040509 @default.
- W4308686508 cites W2768981088 @default.
- W4308686508 cites W2780399352 @default.
- W4308686508 cites W2791435915 @default.
- W4308686508 cites W2802836877 @default.
- W4308686508 cites W2804685648 @default.
- W4308686508 cites W2807256450 @default.
- W4308686508 cites W2887383740 @default.
- W4308686508 cites W2891901614 @default.
- W4308686508 cites W2899031631 @default.
- W4308686508 cites W2901838561 @default.
- W4308686508 cites W2911778150 @default.
- W4308686508 cites W2914756534 @default.
- W4308686508 cites W2943293743 @default.