Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308687097> ?p ?o ?g. }
- W4308687097 abstract "Antimicrobial resistance represents a major threat to human health and knowledge of the underlying mechanisms is therefore vital. Here, we report the discovery and characterization of oxidoreductases that inactivate the broad-spectrum antibiotic chloramphenicol via dual oxidation of the C3-hydroxyl group. Accordingly, chloramphenicol oxidation either depends on standalone glucose-methanol-choline (GMC)-type flavoenzymes, or on additional aldehyde dehydrogenases that boost overall turnover. These enzymes also enable the inactivation of the chloramphenicol analogues thiamphenicol and azidamfenicol, but not of the C3-fluorinated florfenicol. Notably, distinct isofunctional enzymes can be found in Gram-positive (e. g., Streptomyces sp.) and Gram-negative (e. g., Sphingobium sp.) bacteria, which presumably evolved their selectivity for chloramphenicol independently based on phylogenetic analyses. Mechanistic and structural studies provide further insights into the catalytic mechanisms of these biotechnologically interesting enzymes, which, in sum, are both a curse and a blessing by contributing to the spread of antibiotic resistance as well as to the bioremediation of chloramphenicol." @default.
- W4308687097 created "2022-11-14" @default.
- W4308687097 creator A5006954957 @default.
- W4308687097 creator A5011953237 @default.
- W4308687097 creator A5018412626 @default.
- W4308687097 creator A5029767053 @default.
- W4308687097 creator A5038121407 @default.
- W4308687097 creator A5038752800 @default.
- W4308687097 creator A5071798264 @default.
- W4308687097 creator A5073528182 @default.
- W4308687097 creator A5086113901 @default.
- W4308687097 date "2022-12-05" @default.
- W4308687097 modified "2023-10-16" @default.
- W4308687097 title "Bacterial Dehydrogenases Facilitate Oxidative Inactivation and Bioremediation of Chloramphenicol" @default.
- W4308687097 cites W1969580170 @default.
- W4308687097 cites W1989108562 @default.
- W4308687097 cites W1994863517 @default.
- W4308687097 cites W1998054523 @default.
- W4308687097 cites W2010457531 @default.
- W4308687097 cites W2013426695 @default.
- W4308687097 cites W2017519756 @default.
- W4308687097 cites W2019292365 @default.
- W4308687097 cites W2026836885 @default.
- W4308687097 cites W2036874513 @default.
- W4308687097 cites W2037150792 @default.
- W4308687097 cites W2056871617 @default.
- W4308687097 cites W2073793320 @default.
- W4308687097 cites W2076691087 @default.
- W4308687097 cites W2093237163 @default.
- W4308687097 cites W2098084671 @default.
- W4308687097 cites W2098318339 @default.
- W4308687097 cites W2101555813 @default.
- W4308687097 cites W2105092131 @default.
- W4308687097 cites W2109184569 @default.
- W4308687097 cites W2109280068 @default.
- W4308687097 cites W2110803333 @default.
- W4308687097 cites W2110808180 @default.
- W4308687097 cites W2118951527 @default.
- W4308687097 cites W2124026197 @default.
- W4308687097 cites W2124576329 @default.
- W4308687097 cites W2141986488 @default.
- W4308687097 cites W2144010762 @default.
- W4308687097 cites W2144998676 @default.
- W4308687097 cites W2147874841 @default.
- W4308687097 cites W2152900218 @default.
- W4308687097 cites W2153839483 @default.
- W4308687097 cites W2156326383 @default.
- W4308687097 cites W2157463034 @default.
- W4308687097 cites W2165761075 @default.
- W4308687097 cites W2263787140 @default.
- W4308687097 cites W2317330264 @default.
- W4308687097 cites W2317809844 @default.
- W4308687097 cites W2418036698 @default.
- W4308687097 cites W2513436046 @default.
- W4308687097 cites W2585093856 @default.
- W4308687097 cites W2625922223 @default.
- W4308687097 cites W2736085475 @default.
- W4308687097 cites W2741831427 @default.
- W4308687097 cites W2761324167 @default.
- W4308687097 cites W2765322245 @default.
- W4308687097 cites W2783983658 @default.
- W4308687097 cites W2799524357 @default.
- W4308687097 cites W2918126453 @default.
- W4308687097 cites W2985842673 @default.
- W4308687097 cites W3025338372 @default.
- W4308687097 cites W3043380666 @default.
- W4308687097 cites W3084049302 @default.
- W4308687097 cites W3116433157 @default.
- W4308687097 cites W3156458251 @default.
- W4308687097 cites W3177828909 @default.
- W4308687097 cites W4200276866 @default.
- W4308687097 cites W4200356788 @default.
- W4308687097 cites W4248872320 @default.
- W4308687097 cites W793366327 @default.
- W4308687097 doi "https://doi.org/10.1002/cbic.202200632" @default.
- W4308687097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36353978" @default.
- W4308687097 hasPublicationYear "2022" @default.
- W4308687097 type Work @default.
- W4308687097 citedByCount "0" @default.
- W4308687097 crossrefType "journal-article" @default.
- W4308687097 hasAuthorship W4308687097A5006954957 @default.
- W4308687097 hasAuthorship W4308687097A5011953237 @default.
- W4308687097 hasAuthorship W4308687097A5018412626 @default.
- W4308687097 hasAuthorship W4308687097A5029767053 @default.
- W4308687097 hasAuthorship W4308687097A5038121407 @default.
- W4308687097 hasAuthorship W4308687097A5038752800 @default.
- W4308687097 hasAuthorship W4308687097A5071798264 @default.
- W4308687097 hasAuthorship W4308687097A5073528182 @default.
- W4308687097 hasAuthorship W4308687097A5086113901 @default.
- W4308687097 hasConcept C181199279 @default.
- W4308687097 hasConcept C185592680 @default.
- W4308687097 hasConcept C2124996 @default.
- W4308687097 hasConcept C2777728207 @default.
- W4308687097 hasConcept C2778473333 @default.
- W4308687097 hasConcept C501593827 @default.
- W4308687097 hasConcept C523546767 @default.
- W4308687097 hasConcept C54355233 @default.
- W4308687097 hasConcept C55493867 @default.
- W4308687097 hasConcept C86803240 @default.
- W4308687097 hasConcept C89423630 @default.