Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308687690> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W4308687690 abstract "Frailty is strongly associated with cardiometabolic diseases in observational studies. However, whether the observed association reflects causality requires clarification. We performed a bidirectional Mendelian randomisation (MR) study to assess the causal relationship of frailty, measured by the frailty index (FI), with coronary artery disease (CAD), stroke and type 2 diabetes (T2D).We extracted summary genome-wide association statistics for the FI (N = 175,226), CAD (Ncase = 60,801, Ncontrol = 123,504), stroke (Ncase = 40,585, Ncontrol = 406,111) and T2D (Ncase = 55,005, Ncontrol = 400,308) among individuals of European ancestry. Independent genetic variants associated with each phenotype at the genome-wide significance level were taken as instruments. Two-sample MR analyses were primarily conducted using the inverse-variance-weighted method, followed by various sensitivity and validation analyses.Genetically predicted higher FI was significantly associated with increased risk of CAD (odds ratio [OR] 1.52, 95% confidence interval [CI] 1.17-1.96) and T2D (OR 1.80, 95% CI 1.31-2.47) and suggestively associated with higher risk of stroke (OR 1.36, 95% CI 1.01-1.84). In the reverse direction analysis, genetic liability to CAD (beta 0.037, 95% CI 0.019-0.055), stroke (beta 0.096, 95% CI 0.051-0.141) and T2D (beta 0.047, 95% CI 0.036-0.059) showed significant associations with increased FI. Results were stable across sensitivity and validation analyses.Our study strengthened the evidence for a bidirectional causal association between frailty and cardiometabolic diseases. Further understanding of this association will be critical for the optimisation of care in older adults." @default.
- W4308687690 created "2022-11-14" @default.
- W4308687690 creator A5014395746 @default.
- W4308687690 creator A5016974255 @default.
- W4308687690 creator A5037677450 @default.
- W4308687690 creator A5049202649 @default.
- W4308687690 creator A5056803045 @default.
- W4308687690 creator A5065263757 @default.
- W4308687690 creator A5073561639 @default.
- W4308687690 date "2022-11-02" @default.
- W4308687690 modified "2023-10-11" @default.
- W4308687690 title "Frailty and cardiometabolic diseases: a bidirectional Mendelian randomisation study." @default.
- W4308687690 doi "https://doi.org/10.1093/ageing/afac256" @default.
- W4308687690 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36346739" @default.
- W4308687690 hasPublicationYear "2022" @default.
- W4308687690 type Work @default.
- W4308687690 citedByCount "3" @default.
- W4308687690 countsByYear W43086876902023 @default.
- W4308687690 crossrefType "journal-article" @default.
- W4308687690 hasAuthorship W4308687690A5014395746 @default.
- W4308687690 hasAuthorship W4308687690A5016974255 @default.
- W4308687690 hasAuthorship W4308687690A5037677450 @default.
- W4308687690 hasAuthorship W4308687690A5049202649 @default.
- W4308687690 hasAuthorship W4308687690A5056803045 @default.
- W4308687690 hasAuthorship W4308687690A5065263757 @default.
- W4308687690 hasAuthorship W4308687690A5073561639 @default.
- W4308687690 hasConcept C104317684 @default.
- W4308687690 hasConcept C106208931 @default.
- W4308687690 hasConcept C126322002 @default.
- W4308687690 hasConcept C127413603 @default.
- W4308687690 hasConcept C134018914 @default.
- W4308687690 hasConcept C135763542 @default.
- W4308687690 hasConcept C153209595 @default.
- W4308687690 hasConcept C156957248 @default.
- W4308687690 hasConcept C186413461 @default.
- W4308687690 hasConcept C23131810 @default.
- W4308687690 hasConcept C2777180221 @default.
- W4308687690 hasConcept C2778213512 @default.
- W4308687690 hasConcept C2779901538 @default.
- W4308687690 hasConcept C2780645631 @default.
- W4308687690 hasConcept C2993967602 @default.
- W4308687690 hasConcept C44249647 @default.
- W4308687690 hasConcept C54355233 @default.
- W4308687690 hasConcept C555293320 @default.
- W4308687690 hasConcept C71924100 @default.
- W4308687690 hasConcept C78519656 @default.
- W4308687690 hasConcept C86803240 @default.
- W4308687690 hasConceptScore W4308687690C104317684 @default.
- W4308687690 hasConceptScore W4308687690C106208931 @default.
- W4308687690 hasConceptScore W4308687690C126322002 @default.
- W4308687690 hasConceptScore W4308687690C127413603 @default.
- W4308687690 hasConceptScore W4308687690C134018914 @default.
- W4308687690 hasConceptScore W4308687690C135763542 @default.
- W4308687690 hasConceptScore W4308687690C153209595 @default.
- W4308687690 hasConceptScore W4308687690C156957248 @default.
- W4308687690 hasConceptScore W4308687690C186413461 @default.
- W4308687690 hasConceptScore W4308687690C23131810 @default.
- W4308687690 hasConceptScore W4308687690C2777180221 @default.
- W4308687690 hasConceptScore W4308687690C2778213512 @default.
- W4308687690 hasConceptScore W4308687690C2779901538 @default.
- W4308687690 hasConceptScore W4308687690C2780645631 @default.
- W4308687690 hasConceptScore W4308687690C2993967602 @default.
- W4308687690 hasConceptScore W4308687690C44249647 @default.
- W4308687690 hasConceptScore W4308687690C54355233 @default.
- W4308687690 hasConceptScore W4308687690C555293320 @default.
- W4308687690 hasConceptScore W4308687690C71924100 @default.
- W4308687690 hasConceptScore W4308687690C78519656 @default.
- W4308687690 hasConceptScore W4308687690C86803240 @default.
- W4308687690 hasIssue "11" @default.
- W4308687690 hasLocation W43086876901 @default.
- W4308687690 hasOpenAccess W4308687690 @default.
- W4308687690 hasPrimaryLocation W43086876901 @default.
- W4308687690 hasRelatedWork W1990135451 @default.
- W4308687690 hasRelatedWork W2342091482 @default.
- W4308687690 hasRelatedWork W2594299395 @default.
- W4308687690 hasRelatedWork W2804419816 @default.
- W4308687690 hasRelatedWork W2810591415 @default.
- W4308687690 hasRelatedWork W3161311540 @default.
- W4308687690 hasRelatedWork W3196975298 @default.
- W4308687690 hasRelatedWork W4220781113 @default.
- W4308687690 hasRelatedWork W4313402980 @default.
- W4308687690 hasRelatedWork W2133382985 @default.
- W4308687690 hasVolume "51" @default.
- W4308687690 isParatext "false" @default.
- W4308687690 isRetracted "false" @default.
- W4308687690 workType "article" @default.