Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308687999> ?p ?o ?g. }
- W4308687999 endingPage "754" @default.
- W4308687999 startingPage "740" @default.
- W4308687999 abstract "Summary While the bone marrow (BM) microenvironment is significantly remodelled in acute myeloid leukaemia (AML), molecular insight into AML‐specific alterations in the microenvironment has been historically limited by the analysis of liquid marrow aspirates rather than core biopsies that contain solid‐phase BM stroma. We assessed the effect of anthracycline‐ and cytarabine‐based induction chemotherapy on both haematopoietic and non‐haematopoietic cells directly in core BM biopsies using RNA‐seq and histological analysis. We compared matched human core BM biopsies at diagnosis and 2 weeks after cytarabine‐ and anthracycline‐based induction therapy in responders (<5% blasts present after treatment) and non‐responders (≥5% blasts present after treatment). Our data indicated enrichment in vimentin ( VIM ), platelet‐derived growth factor receptor beta ( PDGFRB ) and Snail family transcriptional repressor 2 ( SNAI2 ) transcripts in responders, consistent with the reactivation of the mesenchymal population in the BM stroma. Enrichment of osteoblast maturation‐related transcripts of biglycan ( BGN ), osteopontin ( SPP1 ) and osteonectin ( SPARC ) was observed in non‐responders. To the best of our knowledge, this is the first report demonstrating distinct osteogenic and mesenchymal transcriptome profiles specific to AML response to induction chemotherapy assessed directly in core BM biopsies. Detailing treatment response‐specific alterations in the BM stroma may inform optimised therapeutic strategies for AML." @default.
- W4308687999 created "2022-11-14" @default.
- W4308687999 creator A5001420554 @default.
- W4308687999 creator A5002550316 @default.
- W4308687999 creator A5010292765 @default.
- W4308687999 creator A5012907224 @default.
- W4308687999 creator A5013511698 @default.
- W4308687999 creator A5015302057 @default.
- W4308687999 creator A5017927095 @default.
- W4308687999 creator A5020964256 @default.
- W4308687999 creator A5026630563 @default.
- W4308687999 creator A5031541323 @default.
- W4308687999 creator A5050595720 @default.
- W4308687999 creator A5058210944 @default.
- W4308687999 creator A5061074250 @default.
- W4308687999 creator A5063805112 @default.
- W4308687999 creator A5067088369 @default.
- W4308687999 creator A5069684583 @default.
- W4308687999 creator A5078567397 @default.
- W4308687999 creator A5083327846 @default.
- W4308687999 creator A5085458716 @default.
- W4308687999 creator A5085462251 @default.
- W4308687999 date "2022-11-10" @default.
- W4308687999 modified "2023-10-14" @default.
- W4308687999 title "Transcriptomics of acute myeloid leukaemia core bone marrow biopsies reveals distinct therapy response‐specific osteo‐mesenchymal profiles" @default.
- W4308687999 cites W1951448021 @default.
- W4308687999 cites W1967746635 @default.
- W4308687999 cites W1968266650 @default.
- W4308687999 cites W1983641075 @default.
- W4308687999 cites W2002889467 @default.
- W4308687999 cites W2009412018 @default.
- W4308687999 cites W2010457001 @default.
- W4308687999 cites W2020622102 @default.
- W4308687999 cites W2035618305 @default.
- W4308687999 cites W2044703599 @default.
- W4308687999 cites W2060930865 @default.
- W4308687999 cites W2083030882 @default.
- W4308687999 cites W2086859574 @default.
- W4308687999 cites W2087378917 @default.
- W4308687999 cites W2088651989 @default.
- W4308687999 cites W2090775822 @default.
- W4308687999 cites W2109833357 @default.
- W4308687999 cites W2114409684 @default.
- W4308687999 cites W2120372000 @default.
- W4308687999 cites W2120403731 @default.
- W4308687999 cites W2124157902 @default.
- W4308687999 cites W2130410032 @default.
- W4308687999 cites W2132053539 @default.
- W4308687999 cites W2137881702 @default.
- W4308687999 cites W2157155777 @default.
- W4308687999 cites W2167279371 @default.
- W4308687999 cites W2541514381 @default.
- W4308687999 cites W2570468391 @default.
- W4308687999 cites W2597359422 @default.
- W4308687999 cites W2715749014 @default.
- W4308687999 cites W2731283735 @default.
- W4308687999 cites W2747254185 @default.
- W4308687999 cites W2789257778 @default.
- W4308687999 cites W2808332482 @default.
- W4308687999 cites W2914523197 @default.
- W4308687999 cites W2918296528 @default.
- W4308687999 cites W2919893120 @default.
- W4308687999 cites W2940955647 @default.
- W4308687999 cites W2946721812 @default.
- W4308687999 cites W2982353618 @default.
- W4308687999 cites W3001577527 @default.
- W4308687999 cites W3048385108 @default.
- W4308687999 cites W3048827006 @default.
- W4308687999 cites W3096241657 @default.
- W4308687999 cites W3098001672 @default.
- W4308687999 cites W3130903278 @default.
- W4308687999 cites W3157575545 @default.
- W4308687999 cites W3164477864 @default.
- W4308687999 doi "https://doi.org/10.1111/bjh.18513" @default.
- W4308687999 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36354085" @default.
- W4308687999 hasPublicationYear "2022" @default.
- W4308687999 type Work @default.
- W4308687999 citedByCount "2" @default.
- W4308687999 countsByYear W43086879992022 @default.
- W4308687999 countsByYear W43086879992023 @default.
- W4308687999 crossrefType "journal-article" @default.
- W4308687999 hasAuthorship W4308687999A5001420554 @default.
- W4308687999 hasAuthorship W4308687999A5002550316 @default.
- W4308687999 hasAuthorship W4308687999A5010292765 @default.
- W4308687999 hasAuthorship W4308687999A5012907224 @default.
- W4308687999 hasAuthorship W4308687999A5013511698 @default.
- W4308687999 hasAuthorship W4308687999A5015302057 @default.
- W4308687999 hasAuthorship W4308687999A5017927095 @default.
- W4308687999 hasAuthorship W4308687999A5020964256 @default.
- W4308687999 hasAuthorship W4308687999A5026630563 @default.
- W4308687999 hasAuthorship W4308687999A5031541323 @default.
- W4308687999 hasAuthorship W4308687999A5050595720 @default.
- W4308687999 hasAuthorship W4308687999A5058210944 @default.
- W4308687999 hasAuthorship W4308687999A5061074250 @default.
- W4308687999 hasAuthorship W4308687999A5063805112 @default.
- W4308687999 hasAuthorship W4308687999A5067088369 @default.
- W4308687999 hasAuthorship W4308687999A5069684583 @default.
- W4308687999 hasAuthorship W4308687999A5078567397 @default.