Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308688558> ?p ?o ?g. }
- W4308688558 endingPage "14743" @default.
- W4308688558 startingPage "14732" @default.
- W4308688558 abstract "The sugar moieties of natural flavonoids determine their absorption, bioavailability, and bioactivity in humans. To explore structure-dependent bioactivities of quercetin, isoquercetin, and rutin, which have the same basic skeleton linking different sugar moieties, we systemically investigated the ameliorative effects of dietary these flavonoids on high-fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) of mice. Our results revealed that isoquercetin exhibits the strongest capability in improving NAFLD phenotypes of mice, including body and liver weight gain, glucose intolerance, and systemic inflammation in comparison with quercetin and rutin. At the molecular level, dietary isoquercetin markedly ameliorated liver dysfunction and host metabolic disorders in mice with NAFLD. At the microbial level, the three flavonoids compounds, especially isoquercetin, can effectively regulate the gut microbiota composition, such as genera Akkermansia, Bifidobacterium, and Lactobacillus, which were significantly disrupted in NAFLD mice. These comparative findings offer new insights into the structure-dependent activities of natural flavonoids for NAFLD treatment." @default.
- W4308688558 created "2022-11-14" @default.
- W4308688558 creator A5012628375 @default.
- W4308688558 creator A5015661192 @default.
- W4308688558 creator A5030773951 @default.
- W4308688558 creator A5037128705 @default.
- W4308688558 creator A5041232755 @default.
- W4308688558 creator A5049763017 @default.
- W4308688558 creator A5063163553 @default.
- W4308688558 creator A5069084441 @default.
- W4308688558 creator A5070860842 @default.
- W4308688558 creator A5081698933 @default.
- W4308688558 creator A5084108851 @default.
- W4308688558 date "2022-11-09" @default.
- W4308688558 modified "2023-10-16" @default.
- W4308688558 title "Structural Insights into Amelioration Effects of Quercetin and Its Glycoside Derivatives on NAFLD in Mice by Modulating the Gut Microbiota and Host Metabolism" @default.
- W4308688558 cites W1978840408 @default.
- W4308688558 cites W1992628540 @default.
- W4308688558 cites W1996613294 @default.
- W4308688558 cites W1997437115 @default.
- W4308688558 cites W2018544685 @default.
- W4308688558 cites W2032112360 @default.
- W4308688558 cites W2055593155 @default.
- W4308688558 cites W2085047075 @default.
- W4308688558 cites W2144275312 @default.
- W4308688558 cites W2144312770 @default.
- W4308688558 cites W2147790901 @default.
- W4308688558 cites W2153075279 @default.
- W4308688558 cites W2153576036 @default.
- W4308688558 cites W2537641617 @default.
- W4308688558 cites W2567083638 @default.
- W4308688558 cites W2574979357 @default.
- W4308688558 cites W2611502608 @default.
- W4308688558 cites W2662720755 @default.
- W4308688558 cites W2757980641 @default.
- W4308688558 cites W2758092834 @default.
- W4308688558 cites W2765314233 @default.
- W4308688558 cites W2766903152 @default.
- W4308688558 cites W2782375077 @default.
- W4308688558 cites W2790654889 @default.
- W4308688558 cites W2807728333 @default.
- W4308688558 cites W2810423511 @default.
- W4308688558 cites W2860743873 @default.
- W4308688558 cites W2883853179 @default.
- W4308688558 cites W2901640189 @default.
- W4308688558 cites W2904753778 @default.
- W4308688558 cites W2952484712 @default.
- W4308688558 cites W2953353034 @default.
- W4308688558 cites W2954124338 @default.
- W4308688558 cites W2965692464 @default.
- W4308688558 cites W2981430129 @default.
- W4308688558 cites W2986127397 @default.
- W4308688558 cites W3004503603 @default.
- W4308688558 cites W3013708148 @default.
- W4308688558 cites W3046051940 @default.
- W4308688558 cites W3105817283 @default.
- W4308688558 cites W3130889309 @default.
- W4308688558 cites W3139054321 @default.
- W4308688558 cites W3172005197 @default.
- W4308688558 cites W3199007861 @default.
- W4308688558 cites W3208161049 @default.
- W4308688558 cites W3208165440 @default.
- W4308688558 cites W3208747553 @default.
- W4308688558 cites W3210113611 @default.
- W4308688558 cites W4200024130 @default.
- W4308688558 cites W4200153572 @default.
- W4308688558 cites W4205605379 @default.
- W4308688558 cites W4206568663 @default.
- W4308688558 cites W4291017069 @default.
- W4308688558 cites W4292002738 @default.
- W4308688558 cites W4292113795 @default.
- W4308688558 cites W4292342814 @default.
- W4308688558 cites W4293567551 @default.
- W4308688558 cites W4294012269 @default.
- W4308688558 cites W4294295997 @default.
- W4308688558 doi "https://doi.org/10.1021/acs.jafc.2c06212" @default.
- W4308688558 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36351282" @default.
- W4308688558 hasPublicationYear "2022" @default.
- W4308688558 type Work @default.
- W4308688558 citedByCount "6" @default.
- W4308688558 countsByYear W43086885582023 @default.
- W4308688558 crossrefType "journal-article" @default.
- W4308688558 hasAuthorship W4308688558A5012628375 @default.
- W4308688558 hasAuthorship W4308688558A5015661192 @default.
- W4308688558 hasAuthorship W4308688558A5030773951 @default.
- W4308688558 hasAuthorship W4308688558A5037128705 @default.
- W4308688558 hasAuthorship W4308688558A5041232755 @default.
- W4308688558 hasAuthorship W4308688558A5049763017 @default.
- W4308688558 hasAuthorship W4308688558A5063163553 @default.
- W4308688558 hasAuthorship W4308688558A5069084441 @default.
- W4308688558 hasAuthorship W4308688558A5070860842 @default.
- W4308688558 hasAuthorship W4308688558A5081698933 @default.
- W4308688558 hasAuthorship W4308688558A5084108851 @default.
- W4308688558 hasConcept C126322002 @default.
- W4308688558 hasConcept C185592680 @default.
- W4308688558 hasConcept C2775941767 @default.
- W4308688558 hasConcept C2775963812 @default.
- W4308688558 hasConcept C2776954865 @default.