FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308692423> ?p ?o ?g. }

• W4308692423 abstract "Abstract BACKGROUND Breast cancer (BC) is the most prevalent cancer in women. While usually detected when localized, invasive procedures are still required for diagnosis. METHODS Herein, we developed a novel ultrasensitive pipeline to detect circulating tumour DNA (ctDNA) in a series of 75 plasma samples from localized BC patients prior to any medical intervention. We first performed a tumour-informed analysis to correlate the mutations found in tumour tissue and plasma. Disregarding the tumour data next, we developed an approach to detect tumour mutations in plasma. RESULTS We observed a mutation concordance between tumour and plasma of 29.50% with a sensitivity down to 0.03% in mutant allele frequency (AF). We detected mutations in 33.78% of the samples, identifying 8 patients with plasma-only mutations. Altogether, we determined a specificity of 86.36% and a positive predictive value of 88.46% for BC detection. We demonstrated an association between higher ctDNA median AF and higher tumour grade, multiple plasma mutations with likelihood of relapse and more frequent TP53 plasma mutations in hormone receptor-negative tumours. CONCLUSIONS Overall, we have developed a unique ultra-sensitive sequencing workflow with a technology not previously employed in early BC, paving the way for its application in BC screening." @default.
• W4308692423 created "2022-11-14" @default.
• W4308692423 creator A5000049294 @default.
• W4308692423 creator A5006844108 @default.
• W4308692423 creator A5008608840 @default.
• W4308692423 creator A5011616629 @default.
• W4308692423 creator A5016737776 @default.
• W4308692423 creator A5018922989 @default.
• W4308692423 creator A5030270706 @default.
• W4308692423 creator A5036532311 @default.
• W4308692423 creator A5042262083 @default.
• W4308692423 creator A5042272594 @default.
• W4308692423 creator A5042439922 @default.
• W4308692423 creator A5045491927 @default.
• W4308692423 creator A5045517644 @default.
• W4308692423 creator A5050077867 @default.
• W4308692423 creator A5053893264 @default.
• W4308692423 creator A5056947858 @default.
• W4308692423 creator A5057939150 @default.
• W4308692423 creator A5083095463 @default.
• W4308692423 creator A5090852861 @default.
• W4308692423 date "2022-11-10" @default.
• W4308692423 modified "2023-10-14" @default.
• W4308692423 title "Development of a novel NGS methodology for ultrasensitive circulating tumour DNA detection as a tool for early-stage breast cancer diagnosis" @default.
• W4308692423 cites W1984068087 @default.
• W4308692423 cites W2104641188 @default.
• W4308692423 cites W2116805592 @default.
• W4308692423 cites W2130900820 @default.
• W4308692423 cites W2140575188 @default.
• W4308692423 cites W2150575159 @default.
• W4308692423 cites W2171237493 @default.
• W4308692423 cites W2375577403 @default.
• W4308692423 cites W2521492299 @default.
• W4308692423 cites W2765185461 @default.
• W4308692423 cites W2766307464 @default.
• W4308692423 cites W2783674487 @default.
• W4308692423 cites W2896872272 @default.
• W4308692423 cites W2914484711 @default.
• W4308692423 cites W2964980115 @default.
• W4308692423 cites W2965583450 @default.
• W4308692423 cites W2966618931 @default.
• W4308692423 cites W3027650973 @default.
• W4308692423 cites W3096116629 @default.
• W4308692423 cites W3158571088 @default.
• W4308692423 cites W4226020167 @default.
• W4308692423 cites W4281738617 @default.
• W4308692423 doi "https://doi.org/10.21203/rs.3.rs-2246067/v1" @default.
• W4308692423 hasPublicationYear "2022" @default.
• W4308692423 type Work @default.
• W4308692423 citedByCount "0" @default.
• W4308692423 crossrefType "posted-content" @default.
• W4308692423 hasAuthorship W4308692423A5000049294 @default.
• W4308692423 hasAuthorship W4308692423A5006844108 @default.
• W4308692423 hasAuthorship W4308692423A5008608840 @default.
• W4308692423 hasAuthorship W4308692423A5011616629 @default.
• W4308692423 hasAuthorship W4308692423A5016737776 @default.
• W4308692423 hasAuthorship W4308692423A5018922989 @default.
• W4308692423 hasAuthorship W4308692423A5030270706 @default.
• W4308692423 hasAuthorship W4308692423A5036532311 @default.
• W4308692423 hasAuthorship W4308692423A5042262083 @default.
• W4308692423 hasAuthorship W4308692423A5042272594 @default.
• W4308692423 hasAuthorship W4308692423A5042439922 @default.
• W4308692423 hasAuthorship W4308692423A5045491927 @default.
• W4308692423 hasAuthorship W4308692423A5045517644 @default.
• W4308692423 hasAuthorship W4308692423A5050077867 @default.
• W4308692423 hasAuthorship W4308692423A5053893264 @default.
• W4308692423 hasAuthorship W4308692423A5056947858 @default.
• W4308692423 hasAuthorship W4308692423A5057939150 @default.
• W4308692423 hasAuthorship W4308692423A5083095463 @default.
• W4308692423 hasAuthorship W4308692423A5090852861 @default.
• W4308692423 hasBestOaLocation W43086924231 @default.
• W4308692423 hasConcept C104317684 @default.
• W4308692423 hasConcept C121608353 @default.
• W4308692423 hasConcept C126322002 @default.
• W4308692423 hasConcept C142724271 @default.
• W4308692423 hasConcept C143998085 @default.
• W4308692423 hasConcept C146357865 @default.
• W4308692423 hasConcept C151730666 @default.
• W4308692423 hasConcept C160798450 @default.
• W4308692423 hasConcept C501734568 @default.
• W4308692423 hasConcept C502942594 @default.
• W4308692423 hasConcept C530470458 @default.
• W4308692423 hasConcept C54355233 @default.
• W4308692423 hasConcept C71924100 @default.
• W4308692423 hasConcept C86803240 @default.
• W4308692423 hasConceptScore W4308692423C104317684 @default.
• W4308692423 hasConceptScore W4308692423C121608353 @default.
• W4308692423 hasConceptScore W4308692423C126322002 @default.
• W4308692423 hasConceptScore W4308692423C142724271 @default.
• W4308692423 hasConceptScore W4308692423C143998085 @default.
• W4308692423 hasConceptScore W4308692423C146357865 @default.
• W4308692423 hasConceptScore W4308692423C151730666 @default.
• W4308692423 hasConceptScore W4308692423C160798450 @default.
• W4308692423 hasConceptScore W4308692423C501734568 @default.
• W4308692423 hasConceptScore W4308692423C502942594 @default.
• W4308692423 hasConceptScore W4308692423C530470458 @default.
• W4308692423 hasConceptScore W4308692423C54355233 @default.
• W4308692423 hasConceptScore W4308692423C71924100 @default.
• W4308692423 hasConceptScore W4308692423C86803240 @default.
• W4308692423 hasLocation W43086924231 @default.

• next