Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308695713> ?p ?o ?g. }
- W4308695713 endingPage "3552" @default.
- W4308695713 startingPage "3552" @default.
- W4308695713 abstract "In the physiological condition, the skeletal system's bone resorption and formation are in dynamic balance, called bone homeostasis. However, bone homeostasis is destroyed under pathological conditions, leading to the occurrence of bone metabolism diseases. The expression of hypoxia-inducible factor-1α (HIF-1α) is regulated by oxygen concentration. It affects energy metabolism, which plays a vital role in preventing bone metabolic diseases. This review focuses on the HIF-1α pathway and describes in detail the possible mechanism of its involvement in the regulation of bone homeostasis and angiogenesis, as well as the current experimental studies on the use of HIF-1α in the prevention of bone metabolic diseases. HIF-1α/RANKL/Notch1 pathway bidirectionally regulates the differentiation of macrophages into osteoclasts under different conditions. In addition, HIF-1α is also regulated by many factors, including hypoxia, cofactor activity, non-coding RNA, trace elements, etc. As a pivotal pathway for coupling angiogenesis and osteogenesis, HIF-1α has been widely studied in bone metabolic diseases such as bone defect, osteoporosis, osteonecrosis of the femoral head, fracture, and nonunion. The wide application of biomaterials in bone metabolism also provides a reasonable basis for the experimental study of HIF-1α in preventing bone metabolic diseases." @default.
- W4308695713 created "2022-11-14" @default.
- W4308695713 creator A5006157945 @default.
- W4308695713 creator A5009869994 @default.
- W4308695713 creator A5022034604 @default.
- W4308695713 creator A5026473596 @default.
- W4308695713 creator A5029848325 @default.
- W4308695713 creator A5039143977 @default.
- W4308695713 date "2022-11-10" @default.
- W4308695713 modified "2023-10-18" @default.
- W4308695713 title "HIF-1α Regulates Bone Homeostasis and Angiogenesis, Participating in the Occurrence of Bone Metabolic Diseases" @default.
- W4308695713 cites W1088862126 @default.
- W4308695713 cites W1448587601 @default.
- W4308695713 cites W1546919480 @default.
- W4308695713 cites W1563033895 @default.
- W4308695713 cites W1584619306 @default.
- W4308695713 cites W1604514339 @default.
- W4308695713 cites W1749022239 @default.
- W4308695713 cites W1766726626 @default.
- W4308695713 cites W1775173278 @default.
- W4308695713 cites W1842408926 @default.
- W4308695713 cites W1904071277 @default.
- W4308695713 cites W1938467132 @default.
- W4308695713 cites W1945990513 @default.
- W4308695713 cites W1959995961 @default.
- W4308695713 cites W1962351050 @default.
- W4308695713 cites W1964403243 @default.
- W4308695713 cites W1964992400 @default.
- W4308695713 cites W1972630406 @default.
- W4308695713 cites W1975800300 @default.
- W4308695713 cites W1979242912 @default.
- W4308695713 cites W1981540983 @default.
- W4308695713 cites W1983841918 @default.
- W4308695713 cites W1986463072 @default.
- W4308695713 cites W1990517924 @default.
- W4308695713 cites W1995242599 @default.
- W4308695713 cites W1996446383 @default.
- W4308695713 cites W1997183854 @default.
- W4308695713 cites W1999671240 @default.
- W4308695713 cites W2000239462 @default.
- W4308695713 cites W2001282249 @default.
- W4308695713 cites W2001668394 @default.
- W4308695713 cites W2003201723 @default.
- W4308695713 cites W2004959154 @default.
- W4308695713 cites W2006532804 @default.
- W4308695713 cites W2006622612 @default.
- W4308695713 cites W2007383919 @default.
- W4308695713 cites W2008946188 @default.
- W4308695713 cites W2009488690 @default.
- W4308695713 cites W2009592273 @default.
- W4308695713 cites W2013189110 @default.
- W4308695713 cites W2020730431 @default.
- W4308695713 cites W2022772073 @default.
- W4308695713 cites W2023060122 @default.
- W4308695713 cites W2026032229 @default.
- W4308695713 cites W2027105521 @default.
- W4308695713 cites W2031998606 @default.
- W4308695713 cites W2036121497 @default.
- W4308695713 cites W2037420536 @default.
- W4308695713 cites W2038607522 @default.
- W4308695713 cites W2039913128 @default.
- W4308695713 cites W2040387110 @default.
- W4308695713 cites W2044077824 @default.
- W4308695713 cites W2044726772 @default.
- W4308695713 cites W2046021929 @default.
- W4308695713 cites W2048539785 @default.
- W4308695713 cites W2048600214 @default.
- W4308695713 cites W2049140373 @default.
- W4308695713 cites W2052199680 @default.
- W4308695713 cites W2054438230 @default.
- W4308695713 cites W2055730547 @default.
- W4308695713 cites W2057035809 @default.
- W4308695713 cites W2057649851 @default.
- W4308695713 cites W2060424229 @default.
- W4308695713 cites W2060862711 @default.
- W4308695713 cites W2062466722 @default.
- W4308695713 cites W2063540357 @default.
- W4308695713 cites W2065226530 @default.
- W4308695713 cites W2066128203 @default.
- W4308695713 cites W2069284819 @default.
- W4308695713 cites W2069338957 @default.
- W4308695713 cites W2070320983 @default.
- W4308695713 cites W2075484345 @default.
- W4308695713 cites W2087308788 @default.
- W4308695713 cites W2087363756 @default.
- W4308695713 cites W2087776558 @default.
- W4308695713 cites W2089254126 @default.
- W4308695713 cites W2089866145 @default.
- W4308695713 cites W2092309785 @default.
- W4308695713 cites W2092961583 @default.
- W4308695713 cites W2100553853 @default.
- W4308695713 cites W2116439585 @default.
- W4308695713 cites W2120090919 @default.
- W4308695713 cites W2122367477 @default.
- W4308695713 cites W2128959593 @default.
- W4308695713 cites W2129361250 @default.
- W4308695713 cites W2133826622 @default.
- W4308695713 cites W2138348724 @default.