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- W4308697726 abstract "Infectious diseases are a major contributor to human suffering and the associated socioeconomic burden worldwide. A better understanding of human pathogen-host interactions is a prerequisite for the development of treatment strategies aimed at combatting human pathogen-induced diseases. Model systems that faithfully recapitulate the pathogen-host interactions in humans are critical to gain meaningful insight. Unfortunately, such model systems are not yet available for a number of pathogens. The strict tropism of the hepatitis B (HBV) and C (HCV) viruses for the human liver has made it difficult to study their virus-host interactions during the natural history of these infections. In this case, surplus liver biopsy tissue donated by patients provides an opportunity to obtain a snapshot of the phenomenological and molecular aspects of the human liver of chronically HCV or HBV-infected patients. In this review, we will briefly summarize our own efforts over the years to advance our knowledge of the virus-host interactions during the natural history of chronic HCV and HBV infection." @default.
- W4308697726 created "2022-11-14" @default.
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- W4308697726 date "2022-11-10" @default.
- W4308697726 modified "2023-10-14" @default.
- W4308697726 title "Studying Hepatitis Virus-Host Interactions in Patient Liver Biopsies" @default.
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- W4308697726 doi "https://doi.org/10.3390/v14112490" @default.
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