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• W4308697810 abstract "Dysglycaemia is a metabolic state characterised by an HbA1c level above the normal range and includes anyone with slightly elevated glucose concentrations, impaired fasting glucose, impaired glucose tolerance, or diabetes. Since the term was first coined in 1996, 1 Gerstein HC Yusuf S Dysglycaemia and risk of cardiovascular disease. Lancet. 1996; 347: 949-950 Abstract PubMed Scopus (162) Google Scholar analyses of many prospective studies have clearly shown a progressive relationship between the degree of dysglycaemia and cardiovascular outcomes, including coronary artery disease, stroke, cardiovascular mortality, all-cause mortality, and heart failure. 2 Selvin E Steffes MW Zhu H et al. Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults. N Engl J Med. 2010; 362: 800-811 Crossref PubMed Scopus (1154) Google Scholar , 3 Gerstein HC Swedberg K Carlsson J et al. The hemoglobin A1c level as a progressive risk factor for cardiovascular death, hospitalization for heart failure, or death in patients with chronic heart failure: an analysis of the Candesartan in Heart failure: Assessment of Reduction in Mortality and Morbidity (CHARM) program. Arch Intern Med. 2008; 168: 1699-1704 Crossref PubMed Scopus (178) Google Scholar These findings, meta-analyses of glucose-lowering trials reporting reduced myocardial infarctions, 4 Turnbull FM Abraira C et al. Control GroupIntensive glucose control and macrovascular outcomes in type 2 diabetes. Diabetologia. 2009; 52: 2288-2298 Crossref PubMed Scopus (981) Google Scholar and Mendelian randomisation analyses linking lifetime exposure to elevated glucose with coronary artery disease 5 Ross S Gerstein HC Eikelboom J Anand SS Yusuf S Pare G Mendelian randomization analysis supports the causal role of dysglycaemia and diabetes in the risk of coronary artery disease. Eur Heart J. 2015; 36: 1454-1462 Crossref PubMed Scopus (92) Google Scholar and diastolic dysfunction 6 Vaitinadin NS Shi M Shaffer CM et al. Genetic determinants of body mass index and fasting glucose are mediators of grade 1 diastolic dysfunction. J Am Heart Assoc. 2022; 11e025578 Crossref PubMed Scopus (1) Google Scholar are consistent with a causal relationship between dysglycaemia and cardiovascular outcomes. Nevertheless, no compelling data have shown that short-term glucose lowering reduces the incidence of heart failure. This, and the fact that some glucose-lowering drugs appear to increase its incidence, suggests it is unlikely that glucose control alone could meaningfully prevent heart failure in people with type 2 diabetes. Efficacy and safety of dapagliflozin in patients with heart failure with mildly reduced or preserved ejection fraction by baseline glycaemic status (DELIVER): a subgroup analysis from an international, multicentre, double-blind, randomised, placebo-controlled trialIn patients with heart failure with mildly reduced or preserved ejection fraction, oral dapagliflozin improved heart failure outcomes to a similar extent in three glycaemia subgroups: normoglycaemia, prediabetes, and type 2 diabetes. Moreover, the heart failure benefits of dapagliflozin seem to be consistent across a continuous glycaemic range. Full-Text PDF" @default.
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• W4308697810 date "2022-12-01" @default.
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• W4308697810 title "Reduction in heart failure outcomes with SGLT2 inhibitors irrespective of glycaemic status" @default.
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• W4308697810 doi "https://doi.org/10.1016/s2213-8587(22)00313-8" @default.
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