FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308697944> ?p ?o ?g. }

• W4308697944 endingPage "2486" @default.
• W4308697944 startingPage "2486" @default.
• W4308697944 abstract "Many viruses are known to trigger endoplasmic reticulum (ER) stress in host cells, which in turn can develop a protective unfolded protein response (UPR). Depending on the conditions, the UPR may lead to either cell survival or programmed cell death. One of three UPR branches involves the upregulation of Xbp1 transcription factor caused by the unconventional cytoplasmic splicing of its mRNA. This process is accomplished by the phosphorylated form of the endoribonuclease/protein kinase Ire1/ERN1. Here, we show that the phosphorylation of Ire1 is up-regulated in HeLa cells early in enterovirus infection but down-regulated at later stages. We also find that Ire1 is cleaved in poliovirus- and coxsackievirus-infected HeLa cells 4-6 h after infection. We further show that the Ire1-mediated Xbp1 mRNA splicing is repressed in infected cells in a time-dependent manner. Thus, our results demonstrate the ability of enteroviruses to actively modulate the Ire1-Xbp1 host defensive pathway by inducing phosphorylation and proteolytic cleavage of the ER stress sensor Ire1, as well as down-regulating its splicing activity. Inactivation of Ire1 could be a novel mode of the UPR manipulation employed by viruses to modify the ER stress response in the infected cells." @default.
• W4308697944 created "2022-11-14" @default.
• W4308697944 creator A5002298433 @default.
• W4308697944 creator A5003371095 @default.
• W4308697944 creator A5019987805 @default.
• W4308697944 creator A5022558216 @default.
• W4308697944 creator A5026243567 @default.
• W4308697944 creator A5035551909 @default.
• W4308697944 creator A5054297859 @default.
• W4308697944 creator A5059082381 @default.
• W4308697944 creator A5079852332 @default.
• W4308697944 date "2022-11-10" @default.
• W4308697944 modified "2023-09-27" @default.
• W4308697944 title "Enteroviruses Manipulate the Unfolded Protein Response through Multifaceted Deregulation of the Ire1-Xbp1 Pathway" @default.
• W4308697944 cites W1517876249 @default.
• W4308697944 cites W1883890187 @default.
• W4308697944 cites W1924275678 @default.
• W4308697944 cites W1969039527 @default.
• W4308697944 cites W1969747155 @default.
• W4308697944 cites W1970090817 @default.
• W4308697944 cites W1973400283 @default.
• W4308697944 cites W2001399725 @default.
• W4308697944 cites W2008734149 @default.
• W4308697944 cites W2019271890 @default.
• W4308697944 cites W2024078075 @default.
• W4308697944 cites W2026396911 @default.
• W4308697944 cites W2042546405 @default.
• W4308697944 cites W2050030183 @default.
• W4308697944 cites W2051660831 @default.
• W4308697944 cites W2056031636 @default.
• W4308697944 cites W2058058831 @default.
• W4308697944 cites W2096333094 @default.
• W4308697944 cites W2102847063 @default.
• W4308697944 cites W2103334789 @default.
• W4308697944 cites W2120736516 @default.
• W4308697944 cites W2126274701 @default.
• W4308697944 cites W2127639686 @default.
• W4308697944 cites W2162695817 @default.
• W4308697944 cites W2165089185 @default.
• W4308697944 cites W2192080449 @default.
• W4308697944 cites W2315484453 @default.
• W4308697944 cites W2417334578 @default.
• W4308697944 cites W2583964565 @default.
• W4308697944 cites W2585582035 @default.
• W4308697944 cites W2589120890 @default.
• W4308697944 cites W2766900039 @default.
• W4308697944 cites W2886161140 @default.
• W4308697944 cites W2914520087 @default.
• W4308697944 cites W2936668240 @default.
• W4308697944 cites W2939482774 @default.
• W4308697944 cites W2971237125 @default.
• W4308697944 cites W2994202755 @default.
• W4308697944 cites W3017712133 @default.
• W4308697944 cites W3089565700 @default.
• W4308697944 cites W3104247842 @default.
• W4308697944 cites W3126022571 @default.
• W4308697944 cites W3127962126 @default.
• W4308697944 cites W3136843608 @default.
• W4308697944 cites W3157904844 @default.
• W4308697944 cites W3169695068 @default.
• W4308697944 cites W3177403164 @default.
• W4308697944 cites W3199749282 @default.
• W4308697944 cites W3203263628 @default.
• W4308697944 cites W4211158039 @default.
• W4308697944 cites W4225154549 @default.
• W4308697944 doi "https://doi.org/10.3390/v14112486" @default.
• W4308697944 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36366584" @default.
• W4308697944 hasPublicationYear "2022" @default.
• W4308697944 type Work @default.
• W4308697944 citedByCount "2" @default.
• W4308697944 countsByYear W43086979442022 @default.
• W4308697944 countsByYear W43086979442023 @default.
• W4308697944 crossrefType "journal-article" @default.
• W4308697944 hasAuthorship W4308697944A5002298433 @default.
• W4308697944 hasAuthorship W4308697944A5003371095 @default.
• W4308697944 hasAuthorship W4308697944A5019987805 @default.
• W4308697944 hasAuthorship W4308697944A5022558216 @default.
• W4308697944 hasAuthorship W4308697944A5026243567 @default.
• W4308697944 hasAuthorship W4308697944A5035551909 @default.
• W4308697944 hasAuthorship W4308697944A5054297859 @default.
• W4308697944 hasAuthorship W4308697944A5059082381 @default.
• W4308697944 hasAuthorship W4308697944A5079852332 @default.
• W4308697944 hasBestOaLocation W43086979441 @default.
• W4308697944 hasConcept C104317684 @default.
• W4308697944 hasConcept C11960822 @default.
• W4308697944 hasConcept C139447449 @default.
• W4308697944 hasConcept C158617107 @default.
• W4308697944 hasConcept C2781331208 @default.
• W4308697944 hasConcept C54355233 @default.
• W4308697944 hasConcept C54458228 @default.
• W4308697944 hasConcept C67705224 @default.
• W4308697944 hasConcept C86803240 @default.
• W4308697944 hasConcept C95444343 @default.
• W4308697944 hasConceptScore W4308697944C104317684 @default.
• W4308697944 hasConceptScore W4308697944C11960822 @default.
• W4308697944 hasConceptScore W4308697944C139447449 @default.
• W4308697944 hasConceptScore W4308697944C158617107 @default.
• W4308697944 hasConceptScore W4308697944C2781331208 @default.

• next