FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308697952> ?p ?o ?g. }

• W4308697952 endingPage "6292" @default.
• W4308697952 startingPage "6275" @default.
• W4308697952 abstract "Cathepsin Z (CTSZ) is a cathepsin family member that plays a dual role in the adhesion and migration of immune and tumor cells.The expression pattern of CTSZ in clear cell renal cell carcinoma (ccRCC) was observed by immunohistochemistry and validated by using double-labeling immunofluorescence. Publicly available single-cell sequencing data was used to further define the cell type-specific CTSZ expression in ccRCC. Methylation modification, immune infiltration, and tumor-related signaling enrichment analyses involving CTSZ were performed using multi-omics data. Data from two independent cohorts of anti-programmed death-1 (PD-1) therapeutic clinical trials were used to investigate correlations between CTSZ levels and treatment responses.CTSZ was upregulated in ccRCC tissues compared with adjacent normal tissues at the RNA but not in ccRCC cells. Immunohistochemistry indicated that CTSZ was expressed in tumors infiltrated with lymphocytes. Double immunofluorescence demonstrated that CTSZ was co-expressed with CD68 but not CD8. Single-cell transcriptome data showed macrophage-specific expression of CTSZ in ccRCC. High CTSZ expression was significantly correlated with the enrichment of interferon-γ, epithelial-to-mesenchymal transition, cell cycle, apoptosis pathways, and B cell, macrophage, neutrophil, and dendritic cell infiltrations, as well as the expression of immune checkpoints CTLA4, LAG3, HAVCR2, PDCD1LG2, PDCD1, TIGIT, and SIGLEC15. Hypomethylation modification of cg02744249, cg02744249, and cg22145559 were negatively correlated with CTSZ expression, suggesting an epigenetic mechanism for the regulation of CTSZ expression. Clinically, CTSZ levels were associated with the prognosis of patients with ccRCC (hazard ratio=1.5, P=0.007). Notably, patients with higher CTSZ expression had a worse prognosis with anti-PD-1 monotherapy (hazard ratio=1.51, P=0.039).Macrophage-specific CTSZ was associated with activation of epithelial-to-mesenchymal transition, cell cycle signatures, and a higher infiltration level of B cells, macrophages, neutrophils, and dendritic cells in the tumor microenvironment. High expression of CTSZ could be considered as a prognostic and treatment response biomarker for patients with ccRCC receiving anti-PD-1 immunotherapy." @default.
• W4308697952 created "2022-11-14" @default.
• W4308697952 creator A5007054845 @default.
• W4308697952 creator A5018644007 @default.
• W4308697952 creator A5029162060 @default.
• W4308697952 creator A5042463133 @default.
• W4308697952 creator A5049416052 @default.
• W4308697952 creator A5053307667 @default.
• W4308697952 creator A5053447705 @default.
• W4308697952 creator A5068608685 @default.
• W4308697952 creator A5090536716 @default.
• W4308697952 date "2022-11-01" @default.
• W4308697952 modified "2023-09-26" @default.
• W4308697952 title "Macrophage-Specific Cathepsin as a Marker Correlated with Prognosis and Tumor Microenvironmental Characteristics of Clear Cell Renal Cell Carcinoma" @default.
• W4308697952 cites W1984562788 @default.
• W4308697952 cites W1997484584 @default.
• W4308697952 cites W2003274741 @default.
• W4308697952 cites W2009246192 @default.
• W4308697952 cites W2028867997 @default.
• W4308697952 cites W2092892924 @default.
• W4308697952 cites W2106602966 @default.
• W4308697952 cites W2123032740 @default.
• W4308697952 cites W2133786730 @default.
• W4308697952 cites W2136933812 @default.
• W4308697952 cites W2155363240 @default.
• W4308697952 cites W2163207898 @default.
• W4308697952 cites W2176714462 @default.
• W4308697952 cites W2323655533 @default.
• W4308697952 cites W2335012284 @default.
• W4308697952 cites W2507880739 @default.
• W4308697952 cites W2607129810 @default.
• W4308697952 cites W2729743256 @default.
• W4308697952 cites W2736730167 @default.
• W4308697952 cites W2757487320 @default.
• W4308697952 cites W2765224588 @default.
• W4308697952 cites W2767096838 @default.
• W4308697952 cites W2779695949 @default.
• W4308697952 cites W2804658429 @default.
• W4308697952 cites W2866851485 @default.
• W4308697952 cites W2884842522 @default.
• W4308697952 cites W2892325025 @default.
• W4308697952 cites W2897044695 @default.
• W4308697952 cites W2952406594 @default.
• W4308697952 cites W2999851564 @default.
• W4308697952 cites W3027286012 @default.
• W4308697952 cites W3029490475 @default.
• W4308697952 cites W3091973741 @default.
• W4308697952 cites W3128646645 @default.
• W4308697952 cites W3133932842 @default.
• W4308697952 cites W3165484362 @default.
• W4308697952 cites W3173240031 @default.
• W4308697952 cites W3189247821 @default.
• W4308697952 doi "https://doi.org/10.2147/jir.s375250" @default.
• W4308697952 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36386587" @default.
• W4308697952 hasPublicationYear "2022" @default.
• W4308697952 type Work @default.
• W4308697952 citedByCount "1" @default.
• W4308697952 countsByYear W43086979522023 @default.
• W4308697952 crossrefType "journal-article" @default.
• W4308697952 hasAuthorship W4308697952A5007054845 @default.
• W4308697952 hasAuthorship W4308697952A5018644007 @default.
• W4308697952 hasAuthorship W4308697952A5029162060 @default.
• W4308697952 hasAuthorship W4308697952A5042463133 @default.
• W4308697952 hasAuthorship W4308697952A5049416052 @default.
• W4308697952 hasAuthorship W4308697952A5053307667 @default.
• W4308697952 hasAuthorship W4308697952A5053447705 @default.
• W4308697952 hasAuthorship W4308697952A5068608685 @default.
• W4308697952 hasAuthorship W4308697952A5090536716 @default.
• W4308697952 hasBestOaLocation W43086979521 @default.
• W4308697952 hasConcept C142724271 @default.
• W4308697952 hasConcept C1491633281 @default.
• W4308697952 hasConcept C167672396 @default.
• W4308697952 hasConcept C203014093 @default.
• W4308697952 hasConcept C204232928 @default.
• W4308697952 hasConcept C2776090121 @default.
• W4308697952 hasConcept C2776460901 @default.
• W4308697952 hasConcept C2777472916 @default.
• W4308697952 hasConcept C2781278892 @default.
• W4308697952 hasConcept C29537977 @default.
• W4308697952 hasConcept C502942594 @default.
• W4308697952 hasConcept C54355233 @default.
• W4308697952 hasConcept C71924100 @default.
• W4308697952 hasConcept C86803240 @default.
• W4308697952 hasConcept C8891405 @default.
• W4308697952 hasConceptScore W4308697952C142724271 @default.
• W4308697952 hasConceptScore W4308697952C1491633281 @default.
• W4308697952 hasConceptScore W4308697952C167672396 @default.
• W4308697952 hasConceptScore W4308697952C203014093 @default.
• W4308697952 hasConceptScore W4308697952C204232928 @default.
• W4308697952 hasConceptScore W4308697952C2776090121 @default.
• W4308697952 hasConceptScore W4308697952C2776460901 @default.
• W4308697952 hasConceptScore W4308697952C2777472916 @default.
• W4308697952 hasConceptScore W4308697952C2781278892 @default.
• W4308697952 hasConceptScore W4308697952C29537977 @default.
• W4308697952 hasConceptScore W4308697952C502942594 @default.
• W4308697952 hasConceptScore W4308697952C54355233 @default.
• W4308697952 hasConceptScore W4308697952C71924100 @default.
• W4308697952 hasConceptScore W4308697952C86803240 @default.

• next