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- W4308698368 abstract "Abstract Objective This study aims to discuss the possible therapeutic effect of EDA against hypoxia-induced injury in preeclampsia. Materials and methods Placenta tissues were isolated from pregnant women with or without preeclampsia (PE), and the levels of hypoxia inducible factor (HIF-1α), P-AKT, AKT and PI3K proteins were analyzed by western blotting. The human trophoblast cell line HTR-8/SVneo was treated with cobalt chloride (CoCl 2 ) to establish an in vitro anoxia model. The proliferation, apoptosis and reactive oxygen species (ROS) production rates in the anoxic cells with/out EDA treatment were measured by standard techniques. Results HIF-1α, P-AKT, AKT and PI3K protein levels were significantly higher in the placenta of the PE revlative to the control group. EDA alleviated the CoCl 2 -induced decrease in the viability of HTR-8/SVneo cells, along with apoptosis and ROS production. EDA also reversed the activation of PI3K/AKT pathway in the CoCl 2 -treated trophoblasts. Conclusion EDA protected trophoblasts against hypoxic injury by blocking the PI3K/AKT pathway and is a promising therapeutic option for PE." @default.
- W4308698368 created "2022-11-14" @default.
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- W4308698368 date "2022-11-10" @default.
- W4308698368 modified "2023-10-16" @default.
- W4308698368 title "Edaravone alleviates hypoxia-induced injury by inhibiting PI3K/AKT signaling pathway in HTR-8/SVneo cells" @default.
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- W4308698368 doi "https://doi.org/10.21203/rs.3.rs-2237642/v1" @default.
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