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- W4308698919 abstract "Abstract While loss-of-function mutations in the murine dominant white spotting/Kit (W) locus affect a diverse array of cell lineages, the brain and organs with the highest expression show the least number of defective phenotypes. We performed transcriptome analysis of the brains of Kit W embryos and found prominent gene expression changes specifically in the E12.5 Kit W/W homozygous mutant. Although other potentially causative changes in gene expression were observed, uniform downregulation of ribosomal protein genes and oxidative phosphorylation pathway genes specifically observed in the E12.5 brain may comprise a genetic compensation system exerting protective metabolic effects against the deleterious effect of Kit W/W mutation in the developing brain." @default.
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- W4308698919 date "2022-11-10" @default.
- W4308698919 modified "2023-09-24" @default.
- W4308698919 title "Compensatory gene expression potentially rescues impaired brain development in Kit mutant mice" @default.
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- W4308698919 doi "https://doi.org/10.21203/rs.3.rs-2170478/v1" @default.
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