FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308702431> ?p ?o ?g. }

• W4308702431 abstract "Non-small-cell lung cancer (NSCLC) is the most common lung cancer which has the highest mortality rate in Indonesia. One of the trends in treating cancer is by utilizing peptide vaccines, an immunotherapeutic approach that aims to stimulate the cell-mediated adaptive immune system to recognize cancer-associated peptides. Currently, no peptide vaccines are available in the market for NSCLC treatment. Therefore, this project aims to develop a multi-epitope peptide-based vaccine for NSCLC utilizing citrullinated peptides. Citrullination is a post-translational modification that occurs in cancer cells during autophagy that functions to induce immune responses towards modified self-epitopes such as tumor cells, through activation of PAD enzymes within the APC and target cells. It was found that introducing a common citrullinated neo-antigen peptide such as vimentin and enolase to the immune system could stimulate a higher specific CD4+ T cell response against NSCLC. Moreover, carcinoembryonic antigen (CEA), an antigen that is highly expressed in cancer cells, is also added to increase the vaccine’s specificity and to mobilize both CD4+ and CD8+ T cells. These antigens bind strongly to the MHC Class II alleles such as HLA-DRB1*07:01 and HLA-DRB*11:01, which are predominant alleles in Indonesian populations. Through in silico approach, the peptides generated from CEA, citrullinated vimentin and enolase, were analyzed for their MHC binding strength, immunogenicity, ability to induce IFNγ response, and population coverage. It is expected that the immunodominant antigens presentation is able to induce a potent immune response in NSCLC patients in Indonesia, resulting in tumor eradication." @default.
• W4308702431 created "2022-11-14" @default.
• W4308702431 creator A5007453651 @default.
• W4308702431 creator A5015537029 @default.
• W4308702431 creator A5066633829 @default.
• W4308702431 creator A5076105668 @default.
• W4308702431 creator A5080201504 @default.
• W4308702431 creator A5083201763 @default.
• W4308702431 creator A5089227774 @default.
• W4308702431 date "2022-11-10" @default.
• W4308702431 modified "2023-10-01" @default.
• W4308702431 title "Immunoinformatics Analysis of Citrullinated Antigen as Potential Multi-peptide Lung Cancer Vaccine Candidates for Indonesian Population" @default.
• W4308702431 cites W1966050071 @default.
• W4308702431 cites W1998917415 @default.
• W4308702431 cites W2004177824 @default.
• W4308702431 cites W2024266527 @default.
• W4308702431 cites W2041724121 @default.
• W4308702431 cites W2078895028 @default.
• W4308702431 cites W2095833996 @default.
• W4308702431 cites W2102367710 @default.
• W4308702431 cites W2127635589 @default.
• W4308702431 cites W2134012905 @default.
• W4308702431 cites W2142269152 @default.
• W4308702431 cites W2199315354 @default.
• W4308702431 cites W2228271062 @default.
• W4308702431 cites W2288016727 @default.
• W4308702431 cites W2296115060 @default.
• W4308702431 cites W2418729003 @default.
• W4308702431 cites W2572080171 @default.
• W4308702431 cites W2607286972 @default.
• W4308702431 cites W2611314002 @default.
• W4308702431 cites W2755831618 @default.
• W4308702431 cites W2765329140 @default.
• W4308702431 cites W2781079368 @default.
• W4308702431 cites W2789026035 @default.
• W4308702431 cites W2802731336 @default.
• W4308702431 cites W2907115059 @default.
• W4308702431 cites W2917097596 @default.
• W4308702431 cites W2918182083 @default.
• W4308702431 cites W2959146767 @default.
• W4308702431 cites W2981784931 @default.
• W4308702431 cites W2997749916 @default.
• W4308702431 cites W3000034067 @default.
• W4308702431 cites W3020913613 @default.
• W4308702431 cites W3024570138 @default.
• W4308702431 cites W3027428490 @default.
• W4308702431 cites W3036480920 @default.
• W4308702431 cites W3045549446 @default.
• W4308702431 cites W3115254893 @default.
• W4308702431 cites W3116470704 @default.
• W4308702431 cites W3120248164 @default.
• W4308702431 cites W3194129550 @default.
• W4308702431 cites W3195816749 @default.
• W4308702431 cites W3204571422 @default.
• W4308702431 cites W3204868409 @default.
• W4308702431 cites W2981674933 @default.
• W4308702431 doi "https://doi.org/10.1007/s10989-022-10467-1" @default.
• W4308702431 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36406283" @default.
• W4308702431 hasPublicationYear "2022" @default.
• W4308702431 type Work @default.
• W4308702431 citedByCount "1" @default.
• W4308702431 countsByYear W43087024312023 @default.
• W4308702431 crossrefType "journal-article" @default.
• W4308702431 hasAuthorship W4308702431A5007453651 @default.
• W4308702431 hasAuthorship W4308702431A5015537029 @default.
• W4308702431 hasAuthorship W4308702431A5066633829 @default.
• W4308702431 hasAuthorship W4308702431A5076105668 @default.
• W4308702431 hasAuthorship W4308702431A5080201504 @default.
• W4308702431 hasAuthorship W4308702431A5083201763 @default.
• W4308702431 hasAuthorship W4308702431A5089227774 @default.
• W4308702431 hasBestOaLocation W43087024311 @default.
• W4308702431 hasConcept C143998085 @default.
• W4308702431 hasConcept C147483822 @default.
• W4308702431 hasConcept C195616568 @default.
• W4308702431 hasConcept C203014093 @default.
• W4308702431 hasConcept C2776090121 @default.
• W4308702431 hasConcept C2776256026 @default.
• W4308702431 hasConcept C2776789287 @default.
• W4308702431 hasConcept C2777468819 @default.
• W4308702431 hasConcept C2777701055 @default.
• W4308702431 hasConcept C2778378633 @default.
• W4308702431 hasConcept C2779129087 @default.
• W4308702431 hasConcept C2908647359 @default.
• W4308702431 hasConcept C48632299 @default.
• W4308702431 hasConcept C502942594 @default.
• W4308702431 hasConcept C515207424 @default.
• W4308702431 hasConcept C54355233 @default.
• W4308702431 hasConcept C71924100 @default.
• W4308702431 hasConcept C86803240 @default.
• W4308702431 hasConcept C8891405 @default.
• W4308702431 hasConcept C99454951 @default.
• W4308702431 hasConceptScore W4308702431C143998085 @default.
• W4308702431 hasConceptScore W4308702431C147483822 @default.
• W4308702431 hasConceptScore W4308702431C195616568 @default.
• W4308702431 hasConceptScore W4308702431C203014093 @default.
• W4308702431 hasConceptScore W4308702431C2776090121 @default.
• W4308702431 hasConceptScore W4308702431C2776256026 @default.
• W4308702431 hasConceptScore W4308702431C2776789287 @default.
• W4308702431 hasConceptScore W4308702431C2777468819 @default.
• W4308702431 hasConceptScore W4308702431C2777701055 @default.

• next