FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308702919> ?p ?o ?g. }

• W4308702919 abstract "ABSTRACT ApoL6 is a new LD-associated protein containing an apoprotein-like domain, expressed mainly in adipose tissue, specifically in adipocytes. ApoL6 expression is low in fasting but induced upon feeding. ApoL6 knockdown results in smaller LD with lower triglyceride (TAG) content in adipocytes, while ApoL6 overexpression causes larger LD with higher TAG content. We show that ApoL6 effect in adipocytes is by inhibition of lipolysis. While ApoL6, Perilipin 1 (Plin1) and HSL can form a complex on LD, C-terminal domain of ApoL6 directly interacts with Plin1, to compete with Plin1 binding to HSL through Plin1 N-terminal domain, thereby keeping HSL in a “stand by” status. Thus, ApoL6 ablation decreases WAT mass, protecting mice from diet-induced obesity, while adipose overexpression increases WAT mass to bring obesity and insulin resistance with hepatosteatosis, making ApoL6 a potential future target against obesity and diabetes." @default.
• W4308702919 created "2022-11-14" @default.
• W4308702919 creator A5001193542 @default.
• W4308702919 creator A5008491549 @default.
• W4308702919 creator A5017408586 @default.
• W4308702919 creator A5018475965 @default.
• W4308702919 creator A5027194539 @default.
• W4308702919 creator A5027196755 @default.
• W4308702919 creator A5032219836 @default.
• W4308702919 creator A5038863786 @default.
• W4308702919 creator A5057486939 @default.
• W4308702919 creator A5077920629 @default.
• W4308702919 date "2022-11-10" @default.
• W4308702919 modified "2023-10-16" @default.
• W4308702919 title "A new LD protein, ApoL6 disrupts the Perilipin 1-HSL interaction to inhibit lipolysis" @default.
• W4308702919 cites W1504753880 @default.
• W4308702919 cites W1966723744 @default.
• W4308702919 cites W1969032539 @default.
• W4308702919 cites W1974560613 @default.
• W4308702919 cites W1978921042 @default.
• W4308702919 cites W1983050178 @default.
• W4308702919 cites W1987849310 @default.
• W4308702919 cites W1994949025 @default.
• W4308702919 cites W1995729577 @default.
• W4308702919 cites W2010819467 @default.
• W4308702919 cites W2014154105 @default.
• W4308702919 cites W2015437105 @default.
• W4308702919 cites W2017650269 @default.
• W4308702919 cites W2020389453 @default.
• W4308702919 cites W2021224212 @default.
• W4308702919 cites W2027204269 @default.
• W4308702919 cites W2029318573 @default.
• W4308702919 cites W2029718447 @default.
• W4308702919 cites W2030170677 @default.
• W4308702919 cites W2043076842 @default.
• W4308702919 cites W2053141833 @default.
• W4308702919 cites W2055443182 @default.
• W4308702919 cites W2069229224 @default.
• W4308702919 cites W2077828459 @default.
• W4308702919 cites W2085407582 @default.
• W4308702919 cites W2087867196 @default.
• W4308702919 cites W2089762118 @default.
• W4308702919 cites W2096519088 @default.
• W4308702919 cites W2098681671 @default.
• W4308702919 cites W2101543956 @default.
• W4308702919 cites W2106442657 @default.
• W4308702919 cites W2110839026 @default.
• W4308702919 cites W2119598335 @default.
• W4308702919 cites W2120407995 @default.
• W4308702919 cites W2120506984 @default.
• W4308702919 cites W2121278592 @default.
• W4308702919 cites W2131135287 @default.
• W4308702919 cites W2131256997 @default.
• W4308702919 cites W2141582150 @default.
• W4308702919 cites W2155722642 @default.
• W4308702919 cites W2156560354 @default.
• W4308702919 cites W2169208729 @default.
• W4308702919 cites W2170239474 @default.
• W4308702919 cites W2419302252 @default.
• W4308702919 cites W2472054870 @default.
• W4308702919 cites W2496850373 @default.
• W4308702919 cites W2601642277 @default.
• W4308702919 cites W2762948888 @default.
• W4308702919 cites W2771680905 @default.
• W4308702919 cites W2884624416 @default.
• W4308702919 cites W3011689621 @default.
• W4308702919 cites W4248635034 @default.
• W4308702919 cites W4249992628 @default.
• W4308702919 doi "https://doi.org/10.1101/2022.11.10.516022" @default.
• W4308702919 hasPublicationYear "2022" @default.
• W4308702919 type Work @default.
• W4308702919 citedByCount "0" @default.
• W4308702919 crossrefType "posted-content" @default.
• W4308702919 hasAuthorship W4308702919A5001193542 @default.
• W4308702919 hasAuthorship W4308702919A5008491549 @default.
• W4308702919 hasAuthorship W4308702919A5017408586 @default.
• W4308702919 hasAuthorship W4308702919A5018475965 @default.
• W4308702919 hasAuthorship W4308702919A5027194539 @default.
• W4308702919 hasAuthorship W4308702919A5027196755 @default.
• W4308702919 hasAuthorship W4308702919A5032219836 @default.
• W4308702919 hasAuthorship W4308702919A5038863786 @default.
• W4308702919 hasAuthorship W4308702919A5057486939 @default.
• W4308702919 hasAuthorship W4308702919A5077920629 @default.
• W4308702919 hasBestOaLocation W43087029191 @default.
• W4308702919 hasConcept C104317684 @default.
• W4308702919 hasConcept C126322002 @default.
• W4308702919 hasConcept C134018914 @default.
• W4308702919 hasConcept C140985366 @default.
• W4308702919 hasConcept C171089720 @default.
• W4308702919 hasConcept C173396325 @default.
• W4308702919 hasConcept C185592680 @default.
• W4308702919 hasConcept C25095133 @default.
• W4308702919 hasConcept C2777062983 @default.
• W4308702919 hasConcept C39567582 @default.
• W4308702919 hasConcept C511355011 @default.
• W4308702919 hasConcept C55493867 @default.
• W4308702919 hasConcept C71924100 @default.
• W4308702919 hasConcept C86803240 @default.
• W4308702919 hasConcept C95444343 @default.
• W4308702919 hasConceptScore W4308702919C104317684 @default.

• next