FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308705920> ?p ?o ?g. }

• W4308705920 endingPage "e0276083" @default.
• W4308705920 startingPage "e0276083" @default.
• W4308705920 abstract "This study was to investigate the protective effect of hyperbaric oxygen (HBO) on HT22 and PC12 cell damage caused by oxygen-glucose deprivation/reperfusion-induced ferroptosis. A 2-h oxygen-glucose deprivation and 24-h reperfusion model on HT22 and PC12 cells was used to simulate cerebral ischemia-reperfusion injury. Cell viabilities were detected by Cell Counting Kit-8 (CCK-8) method. The levels of reactive oxygen species (ROS) and lipid reactive oxygen species (Lipid ROS) were detected by fluorescent probes Dihydroethidium (DHE) and C11 BODIPY 581/591. Iron Colorimetric Assay Kit, malondialdehyde (MDA) and glutathione (GSH) activity assay kits were used to detect intracellular iron ion, MDA and GSHcontent. Cell ferroptosis-related ultrastructures were visualized using transmission electron microscopy (TEM). Furthermore, PCR and Western blot analyses were used to detect the expressions of ferroptosis-related genes and proteins. After receiving oxygen-glucose deprivation/reperfusion, the viabilities of HT22 and PC12 cells were significantly decreased; ROS, Lipid ROS, iron ions and MDA accumulation occurred in the cells; GSH contents decreased; TEM showed that cells were ruptured and blebbed, mitochondria atrophied and became smaller, mitochondrial ridges were reduced or even disappeared, and apoptotic bodies appeared. And the expressions of Nrf2, SLC7A11 and GPX4 genes were reduced; the expressions of p-Nrf2/Nrf2, xCT and GPX4 proteins were reduced. Notably, these parameters were significantly reversed by HBO, indicating that HBO can protect HT22 cells and PC12 cells from damage caused by oxygen-glucosedeprivation/reperfusion via the inhibition of Nrf2/System Xc-/GPX4 axis-mediated ferroptosis." @default.
• W4308705920 created "2022-11-14" @default.
• W4308705920 creator A5001945602 @default.
• W4308705920 creator A5034923437 @default.
• W4308705920 creator A5043094856 @default.
• W4308705920 creator A5048094644 @default.
• W4308705920 creator A5059122082 @default.
• W4308705920 creator A5066186474 @default.
• W4308705920 date "2022-11-10" @default.
• W4308705920 modified "2023-09-30" @default.
• W4308705920 title "Hyperbaric oxygen protects HT22 cells and PC12 cells from damage caused by oxygen-glucose deprivation/reperfusion via the inhibition of Nrf2/System Xc-/GPX4 axis-mediated ferroptosis" @default.
• W4308705920 cites W1988777405 @default.
• W4308705920 cites W1991455654 @default.
• W4308705920 cites W1997183854 @default.
• W4308705920 cites W2008757142 @default.
• W4308705920 cites W2014983456 @default.
• W4308705920 cites W2025128734 @default.
• W4308705920 cites W2047870261 @default.
• W4308705920 cites W2099821753 @default.
• W4308705920 cites W2167063200 @default.
• W4308705920 cites W2265062179 @default.
• W4308705920 cites W2270220644 @default.
• W4308705920 cites W2495211675 @default.
• W4308705920 cites W2569311100 @default.
• W4308705920 cites W2619512829 @default.
• W4308705920 cites W2752949400 @default.
• W4308705920 cites W2807334922 @default.
• W4308705920 cites W2892710900 @default.
• W4308705920 cites W2899876893 @default.
• W4308705920 cites W2909457791 @default.
• W4308705920 cites W2915915722 @default.
• W4308705920 cites W2919486784 @default.
• W4308705920 cites W2970235652 @default.
• W4308705920 cites W2971991049 @default.
• W4308705920 cites W2979799294 @default.
• W4308705920 cites W2991448064 @default.
• W4308705920 cites W3001417627 @default.
• W4308705920 cites W3002350800 @default.
• W4308705920 cites W3003960907 @default.
• W4308705920 cites W3011219960 @default.
• W4308705920 cites W3037757547 @default.
• W4308705920 cites W3044551997 @default.
• W4308705920 cites W3048057373 @default.
• W4308705920 cites W3050108631 @default.
• W4308705920 cites W3095921725 @default.
• W4308705920 cites W3107334044 @default.
• W4308705920 cites W3152849972 @default.
• W4308705920 cites W3203757358 @default.
• W4308705920 doi "https://doi.org/10.1371/journal.pone.0276083" @default.
• W4308705920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36355759" @default.
• W4308705920 hasPublicationYear "2022" @default.
• W4308705920 type Work @default.
• W4308705920 citedByCount "3" @default.
• W4308705920 countsByYear W43087059202023 @default.
• W4308705920 crossrefType "journal-article" @default.
• W4308705920 hasAuthorship W4308705920A5001945602 @default.
• W4308705920 hasAuthorship W4308705920A5034923437 @default.
• W4308705920 hasAuthorship W4308705920A5043094856 @default.
• W4308705920 hasAuthorship W4308705920A5048094644 @default.
• W4308705920 hasAuthorship W4308705920A5059122082 @default.
• W4308705920 hasAuthorship W4308705920A5066186474 @default.
• W4308705920 hasBestOaLocation W43087059201 @default.
• W4308705920 hasConcept C104317684 @default.
• W4308705920 hasConcept C1491633281 @default.
• W4308705920 hasConcept C153911025 @default.
• W4308705920 hasConcept C158086472 @default.
• W4308705920 hasConcept C178790620 @default.
• W4308705920 hasConcept C181199279 @default.
• W4308705920 hasConcept C185592680 @default.
• W4308705920 hasConcept C190283241 @default.
• W4308705920 hasConcept C2776151105 @default.
• W4308705920 hasConcept C2776415932 @default.
• W4308705920 hasConcept C2778760513 @default.
• W4308705920 hasConcept C2780829032 @default.
• W4308705920 hasConcept C28859421 @default.
• W4308705920 hasConcept C48349386 @default.
• W4308705920 hasConcept C538909803 @default.
• W4308705920 hasConcept C540031477 @default.
• W4308705920 hasConcept C55493867 @default.
• W4308705920 hasConcept C79879829 @default.
• W4308705920 hasConcept C86803240 @default.
• W4308705920 hasConcept C95444343 @default.
• W4308705920 hasConceptScore W4308705920C104317684 @default.
• W4308705920 hasConceptScore W4308705920C1491633281 @default.
• W4308705920 hasConceptScore W4308705920C153911025 @default.
• W4308705920 hasConceptScore W4308705920C158086472 @default.
• W4308705920 hasConceptScore W4308705920C178790620 @default.
• W4308705920 hasConceptScore W4308705920C181199279 @default.
• W4308705920 hasConceptScore W4308705920C185592680 @default.
• W4308705920 hasConceptScore W4308705920C190283241 @default.
• W4308705920 hasConceptScore W4308705920C2776151105 @default.
• W4308705920 hasConceptScore W4308705920C2776415932 @default.
• W4308705920 hasConceptScore W4308705920C2778760513 @default.
• W4308705920 hasConceptScore W4308705920C2780829032 @default.
• W4308705920 hasConceptScore W4308705920C28859421 @default.
• W4308705920 hasConceptScore W4308705920C48349386 @default.
• W4308705920 hasConceptScore W4308705920C538909803 @default.
• W4308705920 hasConceptScore W4308705920C540031477 @default.

• next