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• W4308706066 abstract "ABSTRACT Mycobacterium tuberculosis (Mtb), the pathogen responsible for tuberculosis (TB), is the leading cause of bacterial disease-related death worldwide. Current antibiotic regimens for the treatment of TB remain dated and suffer from long treatment times as well as the development of drug-resistance. As such, the search for novel chemical modalities that have selective or potent anti-Mtb properties remains an urgent priority, particularly against multidrug resistant (MDR) Mtb strains. Herein, we design and synthesize 35 novel b enzo[c] p henanthridine d erivatives (BPD). The two most potent compounds, BPD-6 and BPD-9, accumulated within the bacterial cell and exhibited strong inhibitory activity (MIC 90 ∼ 2-10 μM) against multiple Mycobacterium strains, while remaining inactive against a range of other Gram-negative and Gram-positive bacteria. BPD-6 and BPD-9 were also effective in reducing Mtb viability within infected macrophages. The two BPD compounds displayed comparable efficacy to rifampicin, a critical frontline antibiotic used for the prevention and treatment of TB. Importantly, BPD-6 and BPD-9 inhibited the growth of multiple MDR Mtb clinical isolates, suggesting a completely novel mechanism of action compared to existing frontline TB dugs. The discovery of BPDs provides novel chemical scaffolds for anti-TB drug discovery. TOC/GRAPHICAL ABSTRACT" @default.
• W4308706066 created "2022-11-14" @default.
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• W4308706066 date "2022-11-08" @default.
• W4308706066 modified "2023-10-16" @default.
• W4308706066 title "Discovery of benzo[c]phenanthridine derivatives with potent activity against multidrug resistant<i>Mycobacterium tuberculosis</i>" @default.
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• W4308706066 doi "https://doi.org/10.1101/2022.11.07.515485" @default.
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