FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308709570> ?p ?o ?g. }

• W4308709570 abstract "Abstract Objectives: To determine the causal association between genetically predicted obesity and the risk of hip osteoarthritis. Methods: We performed two-sample Mendelian randomization (MR) analysis to analyze the association between body mass index (BMI) and hip osteoarthritis using pooled-level genome-wide association study (GWAS) data. The inverse variance weighted (IVW), MR‒Egger, and weighted median methods were used to estimate the causal association. In addition, we applied the MR Steiger filtering method, MR robust adjusted profile score (MR.RAPS) methods, and the MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) global test to examine and address potential horizontal pleiotropy. Results: We found a causal relationship between genetically predicted BMI and the risk of hip osteoarthritis by the IVW method [OR=1.45, 95% confidence interval (CI) = 1.04-2.00, P = 0.02]. In the sensitivity analysis, the results of the MR‒Egger and weighted median methods revealed similar estimations but with a wide CI with lower precision. The funnel plot, MR–Egger intercept, and MR-PRESSO all indicated the absence of a directional pleiotropic effect. In addition, no heterogeneity was observed in the present analysis. Therefore, the result of IVW is most suitable and reliable for the present MR analysis. Conclusion: There is a causal relationship between obesity and a higher risk of hip osteoarthritis, suggesting that weight management may be an intervention for the prevention and management of hip osteoarthritis." @default.
• W4308709570 created "2022-11-14" @default.
• W4308709570 creator A5007006092 @default.
• W4308709570 creator A5009119859 @default.
• W4308709570 creator A5074241934 @default.
• W4308709570 creator A5075216625 @default.
• W4308709570 date "2022-11-10" @default.
• W4308709570 modified "2023-09-24" @default.
• W4308709570 title "Genetically predicted obesity and risk of hip osteoarthritis." @default.
• W4308709570 cites W1905058580 @default.
• W4308709570 cites W1965665343 @default.
• W4308709570 cites W1972218085 @default.
• W4308709570 cites W2002444644 @default.
• W4308709570 cites W2019242939 @default.
• W4308709570 cites W2023821919 @default.
• W4308709570 cites W2028469883 @default.
• W4308709570 cites W2039153962 @default.
• W4308709570 cites W2040259846 @default.
• W4308709570 cites W2060941278 @default.
• W4308709570 cites W2062470313 @default.
• W4308709570 cites W2084292255 @default.
• W4308709570 cites W2103783427 @default.
• W4308709570 cites W2118743532 @default.
• W4308709570 cites W2128371933 @default.
• W4308709570 cites W2132521349 @default.
• W4308709570 cites W2156027229 @default.
• W4308709570 cites W2171777347 @default.
• W4308709570 cites W2324862792 @default.
• W4308709570 cites W2328308194 @default.
• W4308709570 cites W2337796195 @default.
• W4308709570 cites W2341244791 @default.
• W4308709570 cites W2490528887 @default.
• W4308709570 cites W2547738194 @default.
• W4308709570 cites W2614566443 @default.
• W4308709570 cites W2793718487 @default.
• W4308709570 cites W2803072880 @default.
• W4308709570 cites W2805983714 @default.
• W4308709570 cites W2896582829 @default.
• W4308709570 cites W2900550641 @default.
• W4308709570 cites W2945968086 @default.
• W4308709570 cites W2947587829 @default.
• W4308709570 cites W2956730167 @default.
• W4308709570 cites W3010418487 @default.
• W4308709570 cites W3015828108 @default.
• W4308709570 cites W3094413616 @default.
• W4308709570 cites W3170981976 @default.
• W4308709570 cites W4211067786 @default.
• W4308709570 cites W4221090191 @default.
• W4308709570 cites W4255815262 @default.
• W4308709570 cites W4283575774 @default.
• W4308709570 doi "https://doi.org/10.21203/rs.3.rs-2137634/v1" @default.
• W4308709570 hasPublicationYear "2022" @default.
• W4308709570 type Work @default.
• W4308709570 citedByCount "0" @default.
• W4308709570 crossrefType "posted-content" @default.
• W4308709570 hasAuthorship W4308709570A5007006092 @default.
• W4308709570 hasAuthorship W4308709570A5009119859 @default.
• W4308709570 hasAuthorship W4308709570A5074241934 @default.
• W4308709570 hasAuthorship W4308709570A5075216625 @default.
• W4308709570 hasBestOaLocation W43087095701 @default.
• W4308709570 hasConcept C104317684 @default.
• W4308709570 hasConcept C106208931 @default.
• W4308709570 hasConcept C107130276 @default.
• W4308709570 hasConcept C126322002 @default.
• W4308709570 hasConcept C127716648 @default.
• W4308709570 hasConcept C135763542 @default.
• W4308709570 hasConcept C153209595 @default.
• W4308709570 hasConcept C177860879 @default.
• W4308709570 hasConcept C26207810 @default.
• W4308709570 hasConcept C2779901538 @default.
• W4308709570 hasConcept C2780221984 @default.
• W4308709570 hasConcept C2780439572 @default.
• W4308709570 hasConcept C2993967602 @default.
• W4308709570 hasConcept C44249647 @default.
• W4308709570 hasConcept C511355011 @default.
• W4308709570 hasConcept C54355233 @default.
• W4308709570 hasConcept C71924100 @default.
• W4308709570 hasConcept C82605166 @default.
• W4308709570 hasConcept C86803240 @default.
• W4308709570 hasConcept C95190672 @default.
• W4308709570 hasConceptScore W4308709570C104317684 @default.
• W4308709570 hasConceptScore W4308709570C106208931 @default.
• W4308709570 hasConceptScore W4308709570C107130276 @default.
• W4308709570 hasConceptScore W4308709570C126322002 @default.
• W4308709570 hasConceptScore W4308709570C127716648 @default.
• W4308709570 hasConceptScore W4308709570C135763542 @default.
• W4308709570 hasConceptScore W4308709570C153209595 @default.
• W4308709570 hasConceptScore W4308709570C177860879 @default.
• W4308709570 hasConceptScore W4308709570C26207810 @default.
• W4308709570 hasConceptScore W4308709570C2779901538 @default.
• W4308709570 hasConceptScore W4308709570C2780221984 @default.
• W4308709570 hasConceptScore W4308709570C2780439572 @default.
• W4308709570 hasConceptScore W4308709570C2993967602 @default.
• W4308709570 hasConceptScore W4308709570C44249647 @default.
• W4308709570 hasConceptScore W4308709570C511355011 @default.
• W4308709570 hasConceptScore W4308709570C54355233 @default.
• W4308709570 hasConceptScore W4308709570C71924100 @default.
• W4308709570 hasConceptScore W4308709570C82605166 @default.
• W4308709570 hasConceptScore W4308709570C86803240 @default.
• W4308709570 hasConceptScore W4308709570C95190672 @default.

• next