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- W4308713049 abstract "Abstract Blood-brain barrier (BBB) disruption contributes to brain injury and neurological impairment. Tight junctions (TJs) and cell-cell adhesion complexes develop between endothelial cells in the brain to establish and maintain the BBB. Occludin, the first transmembrane protein identified in TJs, has received intense research interest because numerous in vitro studies have suggested its importance in maintaining BBB integrity. However, its role in maintaining BBB integrity after ischemic stroke is less clear owing to the lack of in vivo evidence. This study aimed to investigate the dynamics and function of occludin across the acute and chronic phases after stroke using occludin-deficient mice. By photochemically induced thrombosis model, the expression of occludin was decreased in brain endothelial cells from ischemic lesions. The neurological function of occludin-deficient mice was continuously impaired compared to that of wild-type mice. BBB integrity evaluated by Evans blue and 0.5-kDa fluorescein in the acute phase and by 10-kDa fluorescein isothiocyanate-labeled dextran in the chronic phase was decreased to a greater extent after stroke in occludin-deficient mice. Furthermore, occludin-deficient mice showed decreased Claudin-5 and neovascularization after stroke. Our study reveals how occludin influences BBB integrity after ischemic stroke. Decreased expression of occludin might be associated with the exacerbation of stroke." @default.
- W4308713049 created "2022-11-14" @default.
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- W4308713049 date "2022-11-10" @default.
- W4308713049 modified "2023-09-26" @default.
- W4308713049 title "The tight junction protein occludin modulates blood-brain barrier integrity and neurological function after ischemic stroke in mice" @default.
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- W4308713049 doi "https://doi.org/10.21203/rs.3.rs-2226577/v1" @default.
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