Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308721489> ?p ?o ?g. }
- W4308721489 endingPage "13515" @default.
- W4308721489 startingPage "13515" @default.
- W4308721489 abstract "Alterations in muscle structure and function in chronic kidney disease (CKD) patients are associated with poor outcomes. As key organelles in muscle cell homeostasis, mitochondrial metabolism has been studied in the context of muscle dysfunction in CKD. We conducted a study to determine the contribution of oxidative metabolism, glycolysis and fatty acid oxidation to the muscle metabolism in CKD. Mice developed CKD by exposure to adenine in the diet. Muscle of CKD mice showed significant weight loss compared to non-CKD mice, but only extensor digitorum longus (EDL) muscle showed a decreased number of fibers. There was no difference in the proportion of the various muscle fibers in CKD and non-CKD mice. Muscle of CKD mice had decreased expression of proteins associated with oxidative phosphorylation but increased expression of enzymes and transporters associated with glycolysis. In cell culture, myotubes exposed to uremic serum demonstrated decreased oxygen consumption rates (OCR) when glucose was used as substrate, conserved OCR when fatty acids were used and increased lactate production. In conclusion, mice with adenine-induced CKD developed sarcopenia and with increased glycolytic metabolism but without gross changes in fiber structure. In vitro models of uremic myopathy suggest fatty acid utilization is preserved compared to decreased glucose utilization." @default.
- W4308721489 created "2022-11-15" @default.
- W4308721489 creator A5010010083 @default.
- W4308721489 creator A5021541475 @default.
- W4308721489 creator A5055841016 @default.
- W4308721489 creator A5075186864 @default.
- W4308721489 creator A5085562076 @default.
- W4308721489 date "2022-11-04" @default.
- W4308721489 modified "2023-10-02" @default.
- W4308721489 title "Uremic Myopathy and Mitochondrial Dysfunction in Kidney Disease" @default.
- W4308721489 cites W1414125020 @default.
- W4308721489 cites W1482761079 @default.
- W4308721489 cites W1559339776 @default.
- W4308721489 cites W1600619258 @default.
- W4308721489 cites W161601339 @default.
- W4308721489 cites W1944492097 @default.
- W4308721489 cites W1964166589 @default.
- W4308721489 cites W1988744799 @default.
- W4308721489 cites W1993169074 @default.
- W4308721489 cites W1993842717 @default.
- W4308721489 cites W1996025648 @default.
- W4308721489 cites W2009175015 @default.
- W4308721489 cites W2025196805 @default.
- W4308721489 cites W2038713498 @default.
- W4308721489 cites W2039536423 @default.
- W4308721489 cites W2039829145 @default.
- W4308721489 cites W2041963475 @default.
- W4308721489 cites W2050622384 @default.
- W4308721489 cites W2054450751 @default.
- W4308721489 cites W2054774517 @default.
- W4308721489 cites W2059712789 @default.
- W4308721489 cites W2068048197 @default.
- W4308721489 cites W2075891686 @default.
- W4308721489 cites W2078296699 @default.
- W4308721489 cites W2087839380 @default.
- W4308721489 cites W2103053026 @default.
- W4308721489 cites W2115393877 @default.
- W4308721489 cites W2135746960 @default.
- W4308721489 cites W2137597475 @default.
- W4308721489 cites W2147591250 @default.
- W4308721489 cites W2166129278 @default.
- W4308721489 cites W2167087109 @default.
- W4308721489 cites W2181020360 @default.
- W4308721489 cites W2267851710 @default.
- W4308721489 cites W2305012287 @default.
- W4308721489 cites W2346901260 @default.
- W4308721489 cites W2347016288 @default.
- W4308721489 cites W2625346314 @default.
- W4308721489 cites W2808135039 @default.
- W4308721489 cites W2810661705 @default.
- W4308721489 cites W2914250964 @default.
- W4308721489 cites W2916253731 @default.
- W4308721489 cites W3011095353 @default.
- W4308721489 cites W3036948739 @default.
- W4308721489 cites W3037512190 @default.
- W4308721489 cites W3039265105 @default.
- W4308721489 cites W3041504190 @default.
- W4308721489 cites W3112209863 @default.
- W4308721489 cites W3158965959 @default.
- W4308721489 cites W3159278958 @default.
- W4308721489 cites W3166662757 @default.
- W4308721489 cites W3209564044 @default.
- W4308721489 cites W3214378550 @default.
- W4308721489 cites W4281729335 @default.
- W4308721489 doi "https://doi.org/10.3390/ijms232113515" @default.
- W4308721489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36362298" @default.
- W4308721489 hasPublicationYear "2022" @default.
- W4308721489 type Work @default.
- W4308721489 citedByCount "1" @default.
- W4308721489 crossrefType "journal-article" @default.
- W4308721489 hasAuthorship W4308721489A5010010083 @default.
- W4308721489 hasAuthorship W4308721489A5021541475 @default.
- W4308721489 hasAuthorship W4308721489A5055841016 @default.
- W4308721489 hasAuthorship W4308721489A5075186864 @default.
- W4308721489 hasAuthorship W4308721489A5085562076 @default.
- W4308721489 hasBestOaLocation W43087214891 @default.
- W4308721489 hasConcept C126322002 @default.
- W4308721489 hasConcept C134018914 @default.
- W4308721489 hasConcept C185592680 @default.
- W4308721489 hasConcept C20251656 @default.
- W4308721489 hasConcept C2776991927 @default.
- W4308721489 hasConcept C2777300911 @default.
- W4308721489 hasConcept C2778653478 @default.
- W4308721489 hasConcept C2779959927 @default.
- W4308721489 hasConcept C28859421 @default.
- W4308721489 hasConcept C55493867 @default.
- W4308721489 hasConcept C57600042 @default.
- W4308721489 hasConcept C62231903 @default.
- W4308721489 hasConcept C63645605 @default.
- W4308721489 hasConcept C71924100 @default.
- W4308721489 hasConcept C82714985 @default.
- W4308721489 hasConcept C86803240 @default.
- W4308721489 hasConceptScore W4308721489C126322002 @default.
- W4308721489 hasConceptScore W4308721489C134018914 @default.
- W4308721489 hasConceptScore W4308721489C185592680 @default.
- W4308721489 hasConceptScore W4308721489C20251656 @default.
- W4308721489 hasConceptScore W4308721489C2776991927 @default.
- W4308721489 hasConceptScore W4308721489C2777300911 @default.