FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308721876> ?p ?o ?g. }

• W4308721876 endingPage "2843" @default.
• W4308721876 startingPage "2843" @default.
• W4308721876 abstract "Breast cancer is the most frequent cancer in women. Despite recent clinical advances, new therapeutic approaches are still required. The cystine-glutamate antiporter xCT, encoded by the SLC7A11 gene, which imports cystine in exchange with glutamate, is a potentially new target for breast cancer therapy, being involved in tumor cell redox balance and resistance to therapies. xCT expression is regulated by the oncosuppressor p53, which is mutated in many breast cancers. Indeed, mutant p53 (mut-p53) can induce xCT post-transcriptional down modulation, rendering mut-p53 tumors susceptible to oxidative damage. Interestingly, the drug APR-246, developed to restore the wild-type function of p53 in tumors harboring its mutation, alters the cell redox balance in a p53-independent way, possibly rendering the cells more sensitive to xCT inhibition. Here, we propose a combinatorial treatment based on xCT immunetargeting and APR-246 treatment as a strategy for tackling breast cancer. We demonstrate that combining the inhibition of xCT with the APR-246 drug significantly decreased breast cancer cell viability in vitro and induced apoptosis and affected cancer stem cells’ self-renewal compared to the single treatments. Moreover, the immunetargeting of xCT through DNA vaccination in combination with APR-246 treatment synergistically hinders tumor progression and prevents lung metastasis formation in vivo. These effects can be mediated by the production of anti-xCT antibodies that are able to induce the antibody dependent cellular cytotoxicity of tumor cells. Overall, we demonstrate that DNA vaccination against xCT can synergize with APR-246 treatment and enhance its therapeutic effect. Thus, APR-246 treatment in combination with xCT immunetargeting may open new perspectives in the management of breast cancer." @default.
• W4308721876 created "2022-11-15" @default.
• W4308721876 creator A5001532055 @default.
• W4308721876 creator A5002706536 @default.
• W4308721876 creator A5024927307 @default.
• W4308721876 creator A5051427564 @default.
• W4308721876 creator A5082547177 @default.
• W4308721876 creator A5088428945 @default.
• W4308721876 creator A5088648859 @default.
• W4308721876 date "2022-11-08" @default.
• W4308721876 modified "2023-09-27" @default.
• W4308721876 title "Immunotherapy against the Cystine/Glutamate Antiporter xCT Improves the Efficacy of APR-246 in Preclinical Breast Cancer Models" @default.
• W4308721876 cites W1585109239 @default.
• W4308721876 cites W1919482602 @default.
• W4308721876 cites W1964623882 @default.
• W4308721876 cites W1972053214 @default.
• W4308721876 cites W1997183854 @default.
• W4308721876 cites W2027347004 @default.
• W4308721876 cites W2034530633 @default.
• W4308721876 cites W2042890278 @default.
• W4308721876 cites W2067107606 @default.
• W4308721876 cites W2070619895 @default.
• W4308721876 cites W2080834452 @default.
• W4308721876 cites W2097754306 @default.
• W4308721876 cites W2106213970 @default.
• W4308721876 cites W2107882830 @default.
• W4308721876 cites W2112394028 @default.
• W4308721876 cites W2134729719 @default.
• W4308721876 cites W2159613275 @default.
• W4308721876 cites W2163294546 @default.
• W4308721876 cites W2165798482 @default.
• W4308721876 cites W2171894992 @default.
• W4308721876 cites W2177555958 @default.
• W4308721876 cites W2290932118 @default.
• W4308721876 cites W2329885691 @default.
• W4308721876 cites W2466299625 @default.
• W4308721876 cites W2520938304 @default.
• W4308721876 cites W2589172342 @default.
• W4308721876 cites W2601818643 @default.
• W4308721876 cites W2762087180 @default.
• W4308721876 cites W2766514075 @default.
• W4308721876 cites W2769069311 @default.
• W4308721876 cites W2772763673 @default.
• W4308721876 cites W2776139938 @default.
• W4308721876 cites W2792951836 @default.
• W4308721876 cites W2799688671 @default.
• W4308721876 cites W2804040141 @default.
• W4308721876 cites W2807631974 @default.
• W4308721876 cites W2807723055 @default.
• W4308721876 cites W2887430569 @default.
• W4308721876 cites W2890585509 @default.
• W4308721876 cites W2891832048 @default.
• W4308721876 cites W2895795535 @default.
• W4308721876 cites W2904193053 @default.
• W4308721876 cites W2912580313 @default.
• W4308721876 cites W2916224930 @default.
• W4308721876 cites W2917660960 @default.
• W4308721876 cites W2942397792 @default.
• W4308721876 cites W2945110877 @default.
• W4308721876 cites W2971449756 @default.
• W4308721876 cites W3000279544 @default.
• W4308721876 cites W3005186462 @default.
• W4308721876 cites W3033603816 @default.
• W4308721876 cites W3035213460 @default.
• W4308721876 cites W3118885754 @default.
• W4308721876 cites W3119649652 @default.
• W4308721876 cites W3120795654 @default.
• W4308721876 cites W3128646645 @default.
• W4308721876 cites W3131538053 @default.
• W4308721876 cites W3131928636 @default.
• W4308721876 cites W3184587083 @default.
• W4308721876 doi "https://doi.org/10.3390/biomedicines10112843" @default.
• W4308721876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36359363" @default.
• W4308721876 hasPublicationYear "2022" @default.
• W4308721876 type Work @default.
• W4308721876 citedByCount "3" @default.
• W4308721876 countsByYear W43087218762023 @default.
• W4308721876 crossrefType "journal-article" @default.
• W4308721876 hasAuthorship W4308721876A5001532055 @default.
• W4308721876 hasAuthorship W4308721876A5002706536 @default.
• W4308721876 hasAuthorship W4308721876A5024927307 @default.
• W4308721876 hasAuthorship W4308721876A5051427564 @default.
• W4308721876 hasAuthorship W4308721876A5082547177 @default.
• W4308721876 hasAuthorship W4308721876A5088428945 @default.
• W4308721876 hasAuthorship W4308721876A5088648859 @default.
• W4308721876 hasBestOaLocation W43087218761 @default.
• W4308721876 hasConcept C121608353 @default.
• W4308721876 hasConcept C126322002 @default.
• W4308721876 hasConcept C185592680 @default.
• W4308721876 hasConcept C2777701055 @default.
• W4308721876 hasConcept C502942594 @default.
• W4308721876 hasConcept C530470458 @default.
• W4308721876 hasConcept C71924100 @default.
• W4308721876 hasConcept C86803240 @default.
• W4308721876 hasConcept C96232424 @default.
• W4308721876 hasConcept C98274493 @default.
• W4308721876 hasConceptScore W4308721876C121608353 @default.
• W4308721876 hasConceptScore W4308721876C126322002 @default.

• next