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• W4308722098 endingPage "1487" @default.
• W4308722098 startingPage "1487" @default.
• W4308722098 abstract "The disposal of antibiotics in the aquatic environment favors the selection of bacteria exhibiting antibiotic resistance mechanisms. Quinolones are bactericidal antimicrobials extensively used in both human and animal medicine. Some of the quinolone-resistance mechanisms are encoded by different bacterial genes, whereas others are the result of mutations in the enzymes on which those antibiotics act. The worldwide occurrence of quinolone resistance genes in aquatic environments has been widely reported, particularly in areas impacted by urban discharges. The most commonly reported quinolone resistance gene, qnr, encodes for the Qnr proteins that protect DNA gyrase and topoisomerase IV from quinolone activity. It is important to note that low-level resistance usually constitutes the first step in the development of high-level resistance, because bacteria carrying these genes have an adaptive advantage compared to the highly susceptible bacterial population in environments with low concentrations of this antimicrobial group. In addition, these genes can act additively with chromosomal mutations in the sequences of the target proteins of quinolones leading to high-level quinolone resistance. The occurrence of qnr genes in aquatic environments is most probably caused by the release of bacteria carrying these genes through anthropogenic pollution and maintained by the selective activity of antimicrobial residues discharged into these environments. This increase in the levels of quinolone resistance has consequences both in clinical settings and the wider aquatic environment, where there is an increased exposure risk to the general population, representing a significant threat to the efficacy of quinolone-based human and animal therapies. In this review the potential role of aquatic environments as reservoirs of the qnr genes, their activity in reducing the susceptibility to various quinolones, and the possible ways these genes contribute to the acquisition and spread of high-level resistance to quinolones will be discussed." @default.
• W4308722098 created "2022-11-15" @default.
• W4308722098 creator A5035441202 @default.
• W4308722098 creator A5048928242 @default.
• W4308722098 creator A5057230721 @default.
• W4308722098 creator A5074578527 @default.
• W4308722098 date "2022-10-27" @default.
• W4308722098 modified "2023-10-01" @default.
• W4308722098 title "Aquatic Environments as Hotspots of Transferable Low-Level Quinolone Resistance and Their Potential Contribution to High-Level Quinolone Resistance" @default.
• W4308722098 cites W141312974 @default.
• W4308722098 cites W1536702193 @default.
• W4308722098 cites W1592445079 @default.
• W4308722098 cites W1785734921 @default.
• W4308722098 cites W1910258185 @default.
• W4308722098 cites W1926589852 @default.
• W4308722098 cites W1945127858 @default.
• W4308722098 cites W1964071916 @default.
• W4308722098 cites W1964492646 @default.
• W4308722098 cites W1968997950 @default.
• W4308722098 cites W1971724198 @default.
• W4308722098 cites W1974123350 @default.
• W4308722098 cites W1974898319 @default.
• W4308722098 cites W1975846399 @default.
• W4308722098 cites W1976580333 @default.
• W4308722098 cites W1976800835 @default.
• W4308722098 cites W1978014454 @default.
• W4308722098 cites W1980793184 @default.
• W4308722098 cites W1981031661 @default.
• W4308722098 cites W1983849784 @default.
• W4308722098 cites W1987847971 @default.
• W4308722098 cites W1989341933 @default.
• W4308722098 cites W1990143605 @default.
• W4308722098 cites W1990535513 @default.
• W4308722098 cites W1993534235 @default.
• W4308722098 cites W1996508379 @default.
• W4308722098 cites W1997152162 @default.
• W4308722098 cites W1997607775 @default.
• W4308722098 cites W2000707800 @default.
• W4308722098 cites W2000898667 @default.
• W4308722098 cites W2006805047 @default.
• W4308722098 cites W2007464877 @default.
• W4308722098 cites W2009119563 @default.
• W4308722098 cites W2009410551 @default.
• W4308722098 cites W2009945529 @default.
• W4308722098 cites W2010970840 @default.
• W4308722098 cites W2011291459 @default.
• W4308722098 cites W2013183501 @default.
• W4308722098 cites W2014832032 @default.
• W4308722098 cites W2015786815 @default.
• W4308722098 cites W2016291006 @default.
• W4308722098 cites W2017550427 @default.
• W4308722098 cites W2019515421 @default.
• W4308722098 cites W2020530692 @default.
• W4308722098 cites W2021921643 @default.
• W4308722098 cites W2022907439 @default.
• W4308722098 cites W2025360038 @default.
• W4308722098 cites W2028286132 @default.
• W4308722098 cites W2029063045 @default.
• W4308722098 cites W2031127545 @default.
• W4308722098 cites W2031223726 @default.
• W4308722098 cites W2031913160 @default.
• W4308722098 cites W2033101094 @default.
• W4308722098 cites W2037278032 @default.
• W4308722098 cites W2039556608 @default.
• W4308722098 cites W2042049515 @default.
• W4308722098 cites W2047160440 @default.
• W4308722098 cites W2047468471 @default.
• W4308722098 cites W2049373010 @default.
• W4308722098 cites W2050827648 @default.
• W4308722098 cites W2055535676 @default.
• W4308722098 cites W2055597276 @default.
• W4308722098 cites W2058952776 @default.
• W4308722098 cites W2061662100 @default.
• W4308722098 cites W2061762019 @default.
• W4308722098 cites W2062078436 @default.
• W4308722098 cites W2064983847 @default.
• W4308722098 cites W2070755960 @default.
• W4308722098 cites W2071047813 @default.
• W4308722098 cites W2071451485 @default.
• W4308722098 cites W2072858339 @default.
• W4308722098 cites W2076505260 @default.
• W4308722098 cites W2078981016 @default.
• W4308722098 cites W2082574080 @default.
• W4308722098 cites W2082882443 @default.
• W4308722098 cites W2084699046 @default.
• W4308722098 cites W2086217680 @default.
• W4308722098 cites W2086939553 @default.
• W4308722098 cites W2087153993 @default.
• W4308722098 cites W2087635930 @default.
• W4308722098 cites W2088990214 @default.
• W4308722098 cites W2090273260 @default.
• W4308722098 cites W2091348923 @default.
• W4308722098 cites W2091608447 @default.
• W4308722098 cites W2092894272 @default.
• W4308722098 cites W2094999747 @default.
• W4308722098 cites W2096545068 @default.
• W4308722098 cites W2099446925 @default.
• W4308722098 cites W2100113808 @default.

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