FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308731057> ?p ?o ?g. }

• W4308731057 endingPage "8" @default.
• W4308731057 startingPage "1" @default.
• W4308731057 abstract "Purpose. High lactate levels at hospital admission are significantly associated with poor prognosis in acute pancreatitis patients. Early high lactate clearance is a vital marker for predicting persistent organ failure and mortality in critical illness; however, its value in acute pancreatitis remains unclear. Method. Data were collected from patients who were diagnosed with moderately severe acute pancreatitis and severe acute pancreatitis from January 2017 to December 2020. Initial lactate (within 2 hours after admission) and repeat lactate at 24 hours after admission were measured to determine lactate clearance. Low clearance was defined as a reduction in repeat lactate of less than 30% compared to the first measurement. High clearance was defined as a repeat lactate decrease ≥30% of the first measurement or both first and second lactate levels <2 mmol/L. Baseline data, laboratory data, mortality rate, persistent organ failure rate, and other outcomes such as the incidence of septic pancreatic necrosis and sepsis and the length of hospital stay and intensive care unit (ICU) stay were compared in the low and high lactate clearance groups. Multivariate logistic regression analyses were used to assess the value of lactate clearance for predicting death. Result. Among 4425 acute pancreatitis patients, 3040 patients were diagnosed with moderate or severe acute pancreatitis, and 1028 patients had initial lactate measured. Finally, 390 patients who had initial and 24-hour repeat lactate data were included in the study. Patients who had elevated initial lactate had poor outcomes, and 51 patients in the initial elevated lactate group died. In the lactate normalization group analysis, 293 patients had 24-hour lactate normalization; compared with patients in the nonnormalization group, they had a lower rate of mortality (12.6% vs. 33%). In the lactate clearance group analysis, 70 (21.9%) patients had a low clearance after 24 hours; compared with patients in the high clearance group, they had a higher rate of developing persistent multiorgan failure ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M1> <mi>P</mi> <mo>=</mo> <mn>0.045</mn> </math> ), and the incidence of death was higher (15% vs. 28.6%, <math xmlns=http://www.w3.org/1998/Math/MathML id=M2> <mi>P</mi> <mo>=</mo> <mn>0.007</mn> </math> ). Multivariate logistic analysis showed that 24-hour lactate clearance (OR: 2.007; 95% CI:1.032-3.903, <math xmlns=http://www.w3.org/1998/Math/MathML id=M3> <mi>P</mi> <mo>=</mo> <mn>0.04</mn> </math> ), elevated initial lactate (OR: 2.011; 95% CI:1.023-3.953, <math xmlns=http://www.w3.org/1998/Math/MathML id=M4> <mi>P</mi> <mo>=</mo> <mn>0.043</mn> </math> ), blood urea nitrogen (OR: 2.316; 95% CI:1.061-5.056, <math xmlns=http://www.w3.org/1998/Math/MathML id=M5> <mi>P</mi> <mo>=</mo> <mn>0.035</mn> </math> ), and white blood count (OR: 1.982; 95% CI:1.026-3.829, <math xmlns=http://www.w3.org/1998/Math/MathML id=M6> <mi>P</mi> <mo>=</mo> <mn>0.042</mn> </math> ) were independent predictors of hospital mortality. Conclusion. The 24-hour clearance of lactate is a reliable marker to predict the outcome of moderate and severe acute pancreatitis, and low lactate clearance may indicate that the patient’s condition will worsen, requiring aggressive treatments to improve patient outcomes." @default.
• W4308731057 created "2022-11-15" @default.
• W4308731057 creator A5013879412 @default.
• W4308731057 creator A5016020405 @default.
• W4308731057 creator A5023042484 @default.
• W4308731057 creator A5047432579 @default.
• W4308731057 creator A5049225588 @default.
• W4308731057 creator A5055551398 @default.
• W4308731057 creator A5061188546 @default.
• W4308731057 creator A5068590900 @default.
• W4308731057 creator A5071522799 @default.
• W4308731057 creator A5074183225 @default.
• W4308731057 creator A5078414497 @default.
• W4308731057 creator A5079814205 @default.
• W4308731057 creator A5091638904 @default.
• W4308731057 date "2022-11-09" @default.
• W4308731057 modified "2023-10-17" @default.
• W4308731057 title "Prognostic Value of Arterial Lactate Metabolic Clearance Rate in Moderate and Severe Acute Pancreatitis" @default.
• W4308731057 cites W1576435157 @default.
• W4308731057 cites W1982477772 @default.
• W4308731057 cites W1986360229 @default.
• W4308731057 cites W1991620974 @default.
• W4308731057 cites W1998940476 @default.
• W4308731057 cites W2025568989 @default.
• W4308731057 cites W2033486211 @default.
• W4308731057 cites W2052756505 @default.
• W4308731057 cites W2084394672 @default.
• W4308731057 cites W2085208748 @default.
• W4308731057 cites W2109709238 @default.
• W4308731057 cites W2110617812 @default.
• W4308731057 cites W2111883268 @default.
• W4308731057 cites W2113315206 @default.
• W4308731057 cites W2113740320 @default.
• W4308731057 cites W2145758369 @default.
• W4308731057 cites W2157501515 @default.
• W4308731057 cites W2158623850 @default.
• W4308731057 cites W2165736533 @default.
• W4308731057 cites W222289004 @default.
• W4308731057 cites W2276327439 @default.
• W4308731057 cites W2280404143 @default.
• W4308731057 cites W2325856196 @default.
• W4308731057 cites W2516982490 @default.
• W4308731057 cites W2732962817 @default.
• W4308731057 cites W2749260185 @default.
• W4308731057 cites W2787154718 @default.
• W4308731057 cites W2799592883 @default.
• W4308731057 cites W2807307871 @default.
• W4308731057 cites W2811115492 @default.
• W4308731057 cites W2902220494 @default.
• W4308731057 cites W2915036087 @default.
• W4308731057 cites W2947233445 @default.
• W4308731057 cites W2952733173 @default.
• W4308731057 cites W2991205136 @default.
• W4308731057 cites W3017090521 @default.
• W4308731057 cites W3022028577 @default.
• W4308731057 cites W3045453111 @default.
• W4308731057 cites W3083724722 @default.
• W4308731057 cites W3110774764 @default.
• W4308731057 cites W3113567772 @default.
• W4308731057 cites W3123195699 @default.
• W4308731057 cites W4211258447 @default.
• W4308731057 doi "https://doi.org/10.1155/2022/9233199" @default.
• W4308731057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36408464" @default.
• W4308731057 hasPublicationYear "2022" @default.
• W4308731057 type Work @default.
• W4308731057 citedByCount "1" @default.
• W4308731057 countsByYear W43087310572023 @default.
• W4308731057 crossrefType "journal-article" @default.
• W4308731057 hasAuthorship W4308731057A5013879412 @default.
• W4308731057 hasAuthorship W4308731057A5016020405 @default.
• W4308731057 hasAuthorship W4308731057A5023042484 @default.
• W4308731057 hasAuthorship W4308731057A5047432579 @default.
• W4308731057 hasAuthorship W4308731057A5049225588 @default.
• W4308731057 hasAuthorship W4308731057A5055551398 @default.
• W4308731057 hasAuthorship W4308731057A5061188546 @default.
• W4308731057 hasAuthorship W4308731057A5068590900 @default.
• W4308731057 hasAuthorship W4308731057A5071522799 @default.
• W4308731057 hasAuthorship W4308731057A5074183225 @default.
• W4308731057 hasAuthorship W4308731057A5078414497 @default.
• W4308731057 hasAuthorship W4308731057A5079814205 @default.
• W4308731057 hasAuthorship W4308731057A5091638904 @default.
• W4308731057 hasBestOaLocation W43087310571 @default.
• W4308731057 hasConcept C126322002 @default.
• W4308731057 hasConcept C179755657 @default.
• W4308731057 hasConcept C2775967933 @default.
• W4308731057 hasConcept C2776376669 @default.
• W4308731057 hasConcept C2776670229 @default.
• W4308731057 hasConcept C2778384902 @default.
• W4308731057 hasConcept C2909186138 @default.
• W4308731057 hasConcept C71924100 @default.
• W4308731057 hasConcept C90924648 @default.
• W4308731057 hasConceptScore W4308731057C126322002 @default.
• W4308731057 hasConceptScore W4308731057C179755657 @default.
• W4308731057 hasConceptScore W4308731057C2775967933 @default.
• W4308731057 hasConceptScore W4308731057C2776376669 @default.
• W4308731057 hasConceptScore W4308731057C2776670229 @default.
• W4308731057 hasConceptScore W4308731057C2778384902 @default.
• W4308731057 hasConceptScore W4308731057C2909186138 @default.

• next