FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308731864> ?p ?o ?g. }

• W4308731864 endingPage "e002948" @default.
• W4308731864 startingPage "e002948" @default.
• W4308731864 abstract "Pregnancy entails both pancreatic adaptations with increasing β-cell mass and immunological alterations in healthy women. In this study, we have examined the effects of pregnancy on β-cell function and immunological processes in long-standing type 1 diabetes (L-T1D).Fasting and stimulated C-peptide were measured after an oral glucose tolerance test in pregnant women with L-T1D (n=17) during the first trimester, third trimester, and 5-8 weeks post partum. Two 92-plex Olink panels were used to measure proteins in plasma. Non-pregnant women with L-T1D (n=30) were included for comparison.Fasting C-peptide was detected to a higher degree in women with L-T1D during gestation and after parturition (first trimester: 64.7%, third trimester: 76.5%, and post partum: 64.7% vs 26.7% in non-pregnant women). Also, total insulin secretion and peak C-peptide increased during pregnancy. The plasma protein levels in pregnant women with L-T1D was dynamic, but few analytes were functionally related. Specifically, peripheral levels of prolactin (PRL), prokineticin (PROK)-1, and glucagon (GCG) were elevated during gestation whereas levels of proteins related to leukocyte migration (CCL11), T cell activation (CD28), and antigen presentation (such as CD83) were reduced.In summary, we have found that some C-peptide secretion, that is, an indirect measurement of endogenous insulin production, is regained in women with L-T1D during pregnancy, which might be attributed to elevated peripheral levels of PRL, PROK-1, or GCG." @default.
• W4308731864 created "2022-11-15" @default.
• W4308731864 creator A5013166195 @default.
• W4308731864 creator A5020615799 @default.
• W4308731864 creator A5039853407 @default.
• W4308731864 creator A5056762902 @default.
• W4308731864 creator A5068097174 @default.
• W4308731864 creator A5071871515 @default.
• W4308731864 date "2022-11-01" @default.
• W4308731864 modified "2023-09-26" @default.
• W4308731864 title "Pregnancy induces pancreatic insulin secretion in women with long-standing type 1 diabetes" @default.
• W4308731864 cites W1511621323 @default.
• W4308731864 cites W1549576586 @default.
• W4308731864 cites W1742647754 @default.
• W4308731864 cites W1907435047 @default.
• W4308731864 cites W1979446198 @default.
• W4308731864 cites W1988000632 @default.
• W4308731864 cites W1993046413 @default.
• W4308731864 cites W2016311194 @default.
• W4308731864 cites W2016330248 @default.
• W4308731864 cites W2020390949 @default.
• W4308731864 cites W2029135104 @default.
• W4308731864 cites W2036633211 @default.
• W4308731864 cites W2036800308 @default.
• W4308731864 cites W2043797520 @default.
• W4308731864 cites W2045588054 @default.
• W4308731864 cites W2051567027 @default.
• W4308731864 cites W2051671527 @default.
• W4308731864 cites W2085255789 @default.
• W4308731864 cites W2095093800 @default.
• W4308731864 cites W2098447902 @default.
• W4308731864 cites W2114943001 @default.
• W4308731864 cites W2126028578 @default.
• W4308731864 cites W2134285290 @default.
• W4308731864 cites W2139139173 @default.
• W4308731864 cites W2140211771 @default.
• W4308731864 cites W2156674980 @default.
• W4308731864 cites W2158141897 @default.
• W4308731864 cites W2167232240 @default.
• W4308731864 cites W2168932510 @default.
• W4308731864 cites W2188027077 @default.
• W4308731864 cites W2343756654 @default.
• W4308731864 cites W2343984959 @default.
• W4308731864 cites W2465180814 @default.
• W4308731864 cites W2475031785 @default.
• W4308731864 cites W2568713914 @default.
• W4308731864 cites W2626431036 @default.
• W4308731864 cites W2913756279 @default.
• W4308731864 cites W2916246724 @default.
• W4308731864 cites W2929044764 @default.
• W4308731864 cites W2953822763 @default.
• W4308731864 cites W2971921045 @default.
• W4308731864 cites W3083538471 @default.
• W4308731864 cites W3173416428 @default.
• W4308731864 cites W4233267611 @default.
• W4308731864 cites W4248108867 @default.
• W4308731864 doi "https://doi.org/10.1136/bmjdrc-2022-002948" @default.
• W4308731864 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36351678" @default.
• W4308731864 hasPublicationYear "2022" @default.
• W4308731864 type Work @default.
• W4308731864 citedByCount "0" @default.
• W4308731864 crossrefType "journal-article" @default.
• W4308731864 hasAuthorship W4308731864A5013166195 @default.
• W4308731864 hasAuthorship W4308731864A5020615799 @default.
• W4308731864 hasAuthorship W4308731864A5039853407 @default.
• W4308731864 hasAuthorship W4308731864A5056762902 @default.
• W4308731864 hasAuthorship W4308731864A5068097174 @default.
• W4308731864 hasAuthorship W4308731864A5071871515 @default.
• W4308731864 hasBestOaLocation W43087318641 @default.
• W4308731864 hasConcept C126322002 @default.
• W4308731864 hasConcept C134018914 @default.
• W4308731864 hasConcept C2777180221 @default.
• W4308731864 hasConcept C2778875212 @default.
• W4308731864 hasConcept C2779064019 @default.
• W4308731864 hasConcept C2779234561 @default.
• W4308731864 hasConcept C2779306644 @default.
• W4308731864 hasConcept C2781232474 @default.
• W4308731864 hasConcept C3018745865 @default.
• W4308731864 hasConcept C46973012 @default.
• W4308731864 hasConcept C54355233 @default.
• W4308731864 hasConcept C555293320 @default.
• W4308731864 hasConcept C71315377 @default.
• W4308731864 hasConcept C71924100 @default.
• W4308731864 hasConcept C86803240 @default.
• W4308731864 hasConceptScore W4308731864C126322002 @default.
• W4308731864 hasConceptScore W4308731864C134018914 @default.
• W4308731864 hasConceptScore W4308731864C2777180221 @default.
• W4308731864 hasConceptScore W4308731864C2778875212 @default.
• W4308731864 hasConceptScore W4308731864C2779064019 @default.
• W4308731864 hasConceptScore W4308731864C2779234561 @default.
• W4308731864 hasConceptScore W4308731864C2779306644 @default.
• W4308731864 hasConceptScore W4308731864C2781232474 @default.
• W4308731864 hasConceptScore W4308731864C3018745865 @default.
• W4308731864 hasConceptScore W4308731864C46973012 @default.
• W4308731864 hasConceptScore W4308731864C54355233 @default.
• W4308731864 hasConceptScore W4308731864C555293320 @default.
• W4308731864 hasConceptScore W4308731864C71315377 @default.
• W4308731864 hasConceptScore W4308731864C71924100 @default.

• next