Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308734344> ?p ?o ?g. }
- W4308734344 abstract "The primary cilium is an organelle present in most adult mammalian cells that is considered as an antenna for sensing the local microenvironment. Here, we use intact mouse pancreatic islets of Langerhans to investigate signaling properties of the primary cilium in insulin-secreting β-cells. We find that GABAB1 receptors are strongly enriched at the base of the cilium, but are mobilized to more distal locations upon agonist binding. Using cilia-targeted Ca2+ indicators, we find that activation of GABAB1 receptors induces selective Ca2+ influx into primary cilia through a mechanism that requires voltage-dependent Ca2+ channel activation. Islet β-cells utilize cytosolic Ca2+ increases as the main trigger for insulin secretion, yet we find that increases in cytosolic Ca2+ fail to propagate into the cilium, and that this isolation is largely due to enhanced Ca2+ extrusion in the cilium. Our work reveals local GABA action on primary cilia that involves Ca2+ influx and depends on restricted Ca2+ diffusion between the cilium and cytosol." @default.
- W4308734344 created "2022-11-15" @default.
- W4308734344 creator A5001448846 @default.
- W4308734344 creator A5003103449 @default.
- W4308734344 creator A5013683099 @default.
- W4308734344 creator A5027380526 @default.
- W4308734344 creator A5033955783 @default.
- W4308734344 creator A5049266755 @default.
- W4308734344 creator A5059283425 @default.
- W4308734344 creator A5061235654 @default.
- W4308734344 creator A5061775082 @default.
- W4308734344 creator A5073427188 @default.
- W4308734344 creator A5080796679 @default.
- W4308734344 creator A5086202312 @default.
- W4308734344 creator A5091216718 @default.
- W4308734344 date "2022-11-09" @default.
- W4308734344 modified "2023-10-14" @default.
- W4308734344 title "The β-cell primary cilium is an autonomous Ca2+ compartment for paracrine GABA signaling" @default.
- W4308734344 cites W1507338157 @default.
- W4308734344 cites W1594371684 @default.
- W4308734344 cites W1895908349 @default.
- W4308734344 cites W1956651067 @default.
- W4308734344 cites W1968541164 @default.
- W4308734344 cites W1971116120 @default.
- W4308734344 cites W1974097137 @default.
- W4308734344 cites W1986892307 @default.
- W4308734344 cites W1989789921 @default.
- W4308734344 cites W1992106677 @default.
- W4308734344 cites W2001462151 @default.
- W4308734344 cites W2002377555 @default.
- W4308734344 cites W2022286642 @default.
- W4308734344 cites W2025447674 @default.
- W4308734344 cites W2033384984 @default.
- W4308734344 cites W2045460787 @default.
- W4308734344 cites W2053192587 @default.
- W4308734344 cites W2060610605 @default.
- W4308734344 cites W2063557162 @default.
- W4308734344 cites W2069221978 @default.
- W4308734344 cites W2080092859 @default.
- W4308734344 cites W2080925626 @default.
- W4308734344 cites W2085946814 @default.
- W4308734344 cites W2089125273 @default.
- W4308734344 cites W2111698016 @default.
- W4308734344 cites W2112591804 @default.
- W4308734344 cites W2115014564 @default.
- W4308734344 cites W2119198063 @default.
- W4308734344 cites W2131999768 @default.
- W4308734344 cites W2135672728 @default.
- W4308734344 cites W2136002176 @default.
- W4308734344 cites W2141063928 @default.
- W4308734344 cites W2164156889 @default.
- W4308734344 cites W2167279371 @default.
- W4308734344 cites W2173846013 @default.
- W4308734344 cites W2286284765 @default.
- W4308734344 cites W2311871350 @default.
- W4308734344 cites W2315814529 @default.
- W4308734344 cites W2468625536 @default.
- W4308734344 cites W2559389868 @default.
- W4308734344 cites W2588522258 @default.
- W4308734344 cites W2611267603 @default.
- W4308734344 cites W2752064440 @default.
- W4308734344 cites W2766813480 @default.
- W4308734344 cites W2782472615 @default.
- W4308734344 cites W2790163616 @default.
- W4308734344 cites W2795314247 @default.
- W4308734344 cites W2800009165 @default.
- W4308734344 cites W2803474032 @default.
- W4308734344 cites W2805851175 @default.
- W4308734344 cites W2811493968 @default.
- W4308734344 cites W2883518164 @default.
- W4308734344 cites W2897204017 @default.
- W4308734344 cites W2914184303 @default.
- W4308734344 cites W2921967264 @default.
- W4308734344 cites W2934107946 @default.
- W4308734344 cites W2946896064 @default.
- W4308734344 cites W2966837481 @default.
- W4308734344 cites W2982341276 @default.
- W4308734344 cites W2984694456 @default.
- W4308734344 cites W2995589956 @default.
- W4308734344 cites W2997747468 @default.
- W4308734344 cites W3014557508 @default.
- W4308734344 cites W3045200907 @default.
- W4308734344 cites W3048364861 @default.
- W4308734344 cites W3097406743 @default.
- W4308734344 cites W3112551008 @default.
- W4308734344 cites W3137324541 @default.
- W4308734344 cites W3153776555 @default.
- W4308734344 cites W3159317797 @default.
- W4308734344 cites W3204207210 @default.
- W4308734344 cites W4220958372 @default.
- W4308734344 doi "https://doi.org/10.1083/jcb.202108101" @default.
- W4308734344 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36350286" @default.
- W4308734344 hasPublicationYear "2022" @default.
- W4308734344 type Work @default.
- W4308734344 citedByCount "7" @default.
- W4308734344 countsByYear W43087343442022 @default.
- W4308734344 countsByYear W43087343442023 @default.
- W4308734344 crossrefType "journal-article" @default.
- W4308734344 hasAuthorship W4308734344A5001448846 @default.
- W4308734344 hasAuthorship W4308734344A5003103449 @default.