Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308736832> ?p ?o ?g. }
- W4308736832 abstract "Follicular lymphoma (FL) is an indolent cancer of mature B-cells but with ongoing risk of transformation to more aggressive histology over time. Recurrent mutations associated with transformation have been identified; however, prognostic features that can be discerned at diagnosis could be clinically useful. We present here comprehensive profiling of both tumor and immune compartments in 155 diagnostic FL biopsies at single-cell resolution by mass cytometry. This revealed a diversity of phenotypes but included two recurrent patterns, one which closely resembles germinal center B-cells (GCB) and another which appears more related to memory B-cells (MB). GCB-type tumors are enriched for EZH2, TNFRSF14, and MEF2B mutations, while MB-type tumors contain increased follicular helper T-cells. MB-type and intratumoral phenotypic diversity are independently associated with increased risk of transformation, supporting biological relevance of these features. Notably, a reduced 26-marker panel retains sufficient information to allow phenotypic profiling of future cohorts by conventional flow cytometry." @default.
- W4308736832 created "2022-11-15" @default.
- W4308736832 creator A5006671793 @default.
- W4308736832 creator A5010836878 @default.
- W4308736832 creator A5012550861 @default.
- W4308736832 creator A5013858831 @default.
- W4308736832 creator A5014560211 @default.
- W4308736832 creator A5017830191 @default.
- W4308736832 creator A5017873196 @default.
- W4308736832 creator A5019281057 @default.
- W4308736832 creator A5019921671 @default.
- W4308736832 creator A5021133318 @default.
- W4308736832 creator A5024449539 @default.
- W4308736832 creator A5026641386 @default.
- W4308736832 creator A5029271491 @default.
- W4308736832 creator A5030527051 @default.
- W4308736832 creator A5033441782 @default.
- W4308736832 creator A5035285628 @default.
- W4308736832 creator A5044269394 @default.
- W4308736832 creator A5048030695 @default.
- W4308736832 creator A5059871625 @default.
- W4308736832 creator A5062342454 @default.
- W4308736832 creator A5066428428 @default.
- W4308736832 creator A5066899464 @default.
- W4308736832 creator A5068269625 @default.
- W4308736832 creator A5069512440 @default.
- W4308736832 creator A5072313250 @default.
- W4308736832 creator A5077833764 @default.
- W4308736832 creator A5081644676 @default.
- W4308736832 creator A5083812935 @default.
- W4308736832 creator A5086498395 @default.
- W4308736832 creator A5088613800 @default.
- W4308736832 creator A5091240481 @default.
- W4308736832 date "2022-11-09" @default.
- W4308736832 modified "2023-10-01" @default.
- W4308736832 title "Single-cell profiling reveals a memory B cell-like subtype of follicular lymphoma with increased transformation risk" @default.
- W4308736832 cites W138388202 @default.
- W4308736832 cites W1495503443 @default.
- W4308736832 cites W1514947113 @default.
- W4308736832 cites W1554787345 @default.
- W4308736832 cites W1631320694 @default.
- W4308736832 cites W1836083640 @default.
- W4308736832 cites W1964744337 @default.
- W4308736832 cites W1965827638 @default.
- W4308736832 cites W1978020435 @default.
- W4308736832 cites W2000509813 @default.
- W4308736832 cites W2001775594 @default.
- W4308736832 cites W2010711123 @default.
- W4308736832 cites W2011657487 @default.
- W4308736832 cites W2033070843 @default.
- W4308736832 cites W2038426170 @default.
- W4308736832 cites W2038783844 @default.
- W4308736832 cites W2047835984 @default.
- W4308736832 cites W2071949631 @default.
- W4308736832 cites W2087295215 @default.
- W4308736832 cites W2090739244 @default.
- W4308736832 cites W2112892489 @default.
- W4308736832 cites W2114104545 @default.
- W4308736832 cites W2125837262 @default.
- W4308736832 cites W2132135544 @default.
- W4308736832 cites W2134526812 @default.
- W4308736832 cites W2137688728 @default.
- W4308736832 cites W2138086251 @default.
- W4308736832 cites W2141681661 @default.
- W4308736832 cites W2145745667 @default.
- W4308736832 cites W2149564757 @default.
- W4308736832 cites W2172230584 @default.
- W4308736832 cites W2299654235 @default.
- W4308736832 cites W2425760010 @default.
- W4308736832 cites W2429031812 @default.
- W4308736832 cites W2524917460 @default.
- W4308736832 cites W2550962735 @default.
- W4308736832 cites W2559915999 @default.
- W4308736832 cites W2560950503 @default.
- W4308736832 cites W2561792671 @default.
- W4308736832 cites W2576658154 @default.
- W4308736832 cites W2591862276 @default.
- W4308736832 cites W2598696175 @default.
- W4308736832 cites W2786814228 @default.
- W4308736832 cites W2794660702 @default.
- W4308736832 cites W2797584152 @default.
- W4308736832 cites W2801763724 @default.
- W4308736832 cites W2887034336 @default.
- W4308736832 cites W2892174427 @default.
- W4308736832 cites W2893525181 @default.
- W4308736832 cites W2902652978 @default.
- W4308736832 cites W2912552280 @default.
- W4308736832 cites W2939093246 @default.
- W4308736832 cites W2951843883 @default.
- W4308736832 cites W2965090569 @default.
- W4308736832 cites W2981926059 @default.
- W4308736832 cites W2994693426 @default.
- W4308736832 cites W3008414836 @default.
- W4308736832 cites W3021109105 @default.
- W4308736832 cites W3022594203 @default.
- W4308736832 cites W3127539648 @default.
- W4308736832 cites W3166746990 @default.
- W4308736832 cites W3201257126 @default.
- W4308736832 cites W4212903522 @default.
- W4308736832 cites W4235169531 @default.