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- W4308742489 abstract "WLY-0, as an α-D-glucan with a molecular weight (Mw) of 11.12 kDa, was successfully isolated and purified from Huangshui (HS). The results of methylation and NMR indicated that the mainchain of WLY-0 was (1 → 4)-α-D-glucan, with side chains linking at O-6. Meanwhile, the surface morphology characterization showed that WLY-0 had an irregular flake-like morphology with a rough and uneven surface and varies in sizes from nanometers to microns. Furthermore, WLY-0 relieved the increased paracellular permeability of FD4 and decreased TEER challenged by LPS, meanwhile inhibited the production of pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) and up-regulated the expression of TJ protein (Occludin, Claudin-1, ZO-1, and JAM-A) in Caco-2 cells, so to improve the intestinal barrier function. Our findings about the structural characteristics and biological activities of WLY-0 provided a scientific foundation for the utilization of HS as a potent source of an effective adjuvant in intestinal barrier injury treatment." @default.
- W4308742489 created "2022-11-15" @default.
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- W4308742489 date "2022-12-01" @default.
- W4308742489 modified "2023-10-16" @default.
- W4308742489 title "Structure elucidation and intestinal barrier protection of an α-D-glucan in Huangshui" @default.
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- W4308742489 doi "https://doi.org/10.1016/j.ijbiomac.2022.11.059" @default.
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