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• W4308743555 endingPage "100613" @default.
• W4308743555 startingPage "100613" @default.
• W4308743555 abstract "The use of aspirin in the primary prevention of diseases is debatable. Herbal products might be considered potential substitutes for synthetic chemicals in many situations. Tanacetum parthenium or feverfew is widely used to treat various inflammatory diseases, fever, and headaches. But could it be considered a herbal alternative to aspirin? This double-blind randomized clinical trial was designed to evaluate the effects of feverfew on various immunological and coagulation factors in healthy individuals and to assess its potential adverse effects. Among healthy and non-smoking adult men of Fasa (IRAN), 60 individuals were randomly recruited into control and intervention groups. Participants consumed one capsule (250 mg) of Tanacetum parthenium or placebo every day for 2 weeks. Blood samples were taken from everyone and inflammatory cytokines, prothrombin time (PT), partial thromboplastin time (PTT), and liver function tests were assessed. T-test, Chi-square (X2) distribution, and linear regression analyses were done. The increased serum level of PT was shown in the intervention group (12.2 ± 0.7 s) compared to the control group (11.6 ± 0.6 s) in the t-test (p = 0.003) and the regression model (p = 0.04). PTT (41.8 ± 5.7 s compared to 33.0 ± 5.1 s), IL-17A (28.0 ± 28.6 compared to 18.9 ± 15.9 pg/ml) and Chemokine MCP-1 (1061.3 ± 705.3 compared to 714.2 ± 273.0 pg/ml) also showed a significant increase in the intervention group after consumption of feverfew (P values= 0.001, 0.048 and 0.017 respectively). The data suggested that Tanacetum parthenium (L.) may have anticoagulant properties. It is recommended that more studies with greater sample sizes and longer follow-ups be done in this regard." @default.
• W4308743555 created "2022-11-15" @default.
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• W4308743555 date "2022-12-01" @default.
• W4308743555 modified "2023-09-25" @default.
• W4308743555 title "Evaluation of anticoagulant and inflammatory effects of Tanacetum parthenium (L.) in a randomized controlled clinical trial" @default.
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• W4308743555 doi "https://doi.org/10.1016/j.hermed.2022.100613" @default.
• W4308743555 hasPublicationYear "2022" @default.
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