Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308751837> ?p ?o ?g. }
- W4308751837 abstract "Pulmonary arterial hypertension (PAH) is a progressive, devastating disease, and its main histological manifestation is an occlusive pulmonary arteriopathy. One important functional component of PAH is aberrant endothelial cell (EC) function including apoptosis-resistance, unchecked proliferation, and impaired migration. The mechanisms leading to and maintaining physiologic and aberrant EC function are not fully understood. Here, we tested the hypothesis that in PAH, ECs have increased expression of the transmembrane protein integrin-β5, which contributes to migration and survival under physiologic and pathological conditions, but also to endothelial-to-mesenchymal transition (EnMT). We found that elevated integrin-β5 expression in pulmonary artery lesions and lung tissue from PAH patients and rats with PH induced by chronic hypoxia and injection of CD117+ rat lung EC clones. These EC clones exhibited elevated expression of integrin-β5 and its heterodimerization partner integrin-αν and showed accelerated barrier formation. Inhibition of integrin-ανβ5 in vitro partially blocked transforming growth factor (TGF)-β1-induced EnMT gene expression in rat lung control ECs and less in rat lung EC clones and human lung microvascular ECs. Inhibition of integrin-ανβ5 promoted endothelial dysfunction as shown by reduced migration in a scratch assay and increased apoptosis in synergism with TGF-β1. In vivo, blocking of integrin-ανβ5 exaggerated PH induced by chronic hypoxia and CD117+ EC clones in rats. In summary, we found a role for integrin-ανβ5 in lung endothelial survival and migration, but also a partial contribution to TGF-β1-induced EnMT gene expression. Our results suggest that integrin-ανβ5 is required for physiologic function of ECs and lung vascular homeostasis." @default.
- W4308751837 created "2022-11-15" @default.
- W4308751837 creator A5010580050 @default.
- W4308751837 creator A5011120474 @default.
- W4308751837 creator A5011834888 @default.
- W4308751837 creator A5027801690 @default.
- W4308751837 creator A5028862037 @default.
- W4308751837 creator A5042168852 @default.
- W4308751837 creator A5045287232 @default.
- W4308751837 creator A5057296066 @default.
- W4308751837 creator A5064911466 @default.
- W4308751837 creator A5066550619 @default.
- W4308751837 creator A5072063587 @default.
- W4308751837 creator A5088113721 @default.
- W4308751837 date "2022-10-01" @default.
- W4308751837 modified "2023-10-14" @default.
- W4308751837 title "Dichotomous role of integrin‐β5 in lung endothelial cells" @default.
- W4308751837 cites W1553909464 @default.
- W4308751837 cites W1595810968 @default.
- W4308751837 cites W1740440689 @default.
- W4308751837 cites W1809627334 @default.
- W4308751837 cites W1965559724 @default.
- W4308751837 cites W1969569982 @default.
- W4308751837 cites W1970325164 @default.
- W4308751837 cites W1991011809 @default.
- W4308751837 cites W1992400293 @default.
- W4308751837 cites W1996556203 @default.
- W4308751837 cites W2004127755 @default.
- W4308751837 cites W2004351703 @default.
- W4308751837 cites W2019125835 @default.
- W4308751837 cites W2019555687 @default.
- W4308751837 cites W2041034019 @default.
- W4308751837 cites W2044923102 @default.
- W4308751837 cites W2056897025 @default.
- W4308751837 cites W2058843732 @default.
- W4308751837 cites W2065433187 @default.
- W4308751837 cites W2068200901 @default.
- W4308751837 cites W2070002665 @default.
- W4308751837 cites W2076366164 @default.
- W4308751837 cites W2077065151 @default.
- W4308751837 cites W2077884715 @default.
- W4308751837 cites W2079353906 @default.
- W4308751837 cites W2079748533 @default.
- W4308751837 cites W2079934082 @default.
- W4308751837 cites W2089812396 @default.
- W4308751837 cites W2098508359 @default.
- W4308751837 cites W2108244474 @default.
- W4308751837 cites W2120187885 @default.
- W4308751837 cites W2121701455 @default.
- W4308751837 cites W2124864209 @default.
- W4308751837 cites W2126104153 @default.
- W4308751837 cites W2132928559 @default.
- W4308751837 cites W2141260105 @default.
- W4308751837 cites W2146234408 @default.
- W4308751837 cites W2150480894 @default.
- W4308751837 cites W2158564701 @default.
- W4308751837 cites W2161237374 @default.
- W4308751837 cites W2162168363 @default.
- W4308751837 cites W2169970560 @default.
- W4308751837 cites W2171600273 @default.
- W4308751837 cites W2313332678 @default.
- W4308751837 cites W2341828371 @default.
- W4308751837 cites W2344643399 @default.
- W4308751837 cites W2418960857 @default.
- W4308751837 cites W2759764474 @default.
- W4308751837 cites W2810667939 @default.
- W4308751837 cites W2888126954 @default.
- W4308751837 cites W2889744577 @default.
- W4308751837 cites W2890682818 @default.
- W4308751837 cites W2893871688 @default.
- W4308751837 cites W2903151902 @default.
- W4308751837 cites W2905582258 @default.
- W4308751837 cites W2920879064 @default.
- W4308751837 cites W2921841124 @default.
- W4308751837 cites W2995426659 @default.
- W4308751837 cites W3000756841 @default.
- W4308751837 cites W3011158566 @default.
- W4308751837 cites W3033947697 @default.
- W4308751837 cites W3091772497 @default.
- W4308751837 cites W3125330298 @default.
- W4308751837 cites W3127039506 @default.
- W4308751837 cites W4248637822 @default.
- W4308751837 doi "https://doi.org/10.1002/pul2.12156" @default.
- W4308751837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36438452" @default.
- W4308751837 hasPublicationYear "2022" @default.
- W4308751837 type Work @default.
- W4308751837 citedByCount "1" @default.
- W4308751837 countsByYear W43087518372023 @default.
- W4308751837 crossrefType "journal-article" @default.
- W4308751837 hasAuthorship W4308751837A5010580050 @default.
- W4308751837 hasAuthorship W4308751837A5011120474 @default.
- W4308751837 hasAuthorship W4308751837A5011834888 @default.
- W4308751837 hasAuthorship W4308751837A5027801690 @default.
- W4308751837 hasAuthorship W4308751837A5028862037 @default.
- W4308751837 hasAuthorship W4308751837A5042168852 @default.
- W4308751837 hasAuthorship W4308751837A5045287232 @default.
- W4308751837 hasAuthorship W4308751837A5057296066 @default.
- W4308751837 hasAuthorship W4308751837A5064911466 @default.
- W4308751837 hasAuthorship W4308751837A5066550619 @default.
- W4308751837 hasAuthorship W4308751837A5072063587 @default.