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- W4308752107 abstract "Cancer is the second leading cause of death globally, with therapeutic resistance being a major cause of treatment failure in the clinic. The dynamic signaling that occurs between tumor cells and the diverse cells of the surrounding tumor microenvironment actively promotes disease progression and therapeutic resistance. Improving the understanding of how tumors evolve following therapy and the molecular mechanisms underpinning de novo or acquired resistance is thus critical for the identification of new targets and for the subsequent development of more effective combination regimens. Simultaneously targeting multiple hallmark capabilities of cancer to circumvent adaptive or evasive resistance may lead to significantly improved treatment response in the clinic. Here, the latest applications of functional genomics tools, such as clustered regularly interspaced short palindromic repeats (CRISPR) editing, to characterize the dynamic cancer resistance mechanisms, from improving the understanding of resistance to classical chemotherapeutics, to deciphering unique mechanisms that regulate tumor responses to new targeted agents and immunotherapies, are discussed. Potential avenues of future research in combating therapeutic resistance, the contribution of tumor-stroma signaling in this setting, and how advanced functional genomics tools can help streamline the identification of key molecular determinants of drug response are explored." @default.
- W4308752107 created "2022-11-15" @default.
- W4308752107 creator A5000111007 @default.
- W4308752107 creator A5003623801 @default.
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- W4308752107 creator A5046401350 @default.
- W4308752107 creator A5055343386 @default.
- W4308752107 creator A5073106472 @default.
- W4308752107 date "2022-11-09" @default.
- W4308752107 modified "2023-10-09" @default.
- W4308752107 title "A CRISPR Path to Finding Vulnerabilities and Solving Drug Resistance: Targeting the Diverse Cancer Landscape and Its Ecosystem" @default.
- W4308752107 cites W1973260880 @default.
- W4308752107 cites W1982969769 @default.
- W4308752107 cites W1987313243 @default.
- W4308752107 cites W1999068651 @default.
- W4308752107 cites W2002697796 @default.
- W4308752107 cites W2003171404 @default.
- W4308752107 cites W2019218097 @default.
- W4308752107 cites W2032211985 @default.
- W4308752107 cites W2045435533 @default.
- W4308752107 cites W2051165598 @default.
- W4308752107 cites W2089082314 @default.
- W4308752107 cites W2096261947 @default.
- W4308752107 cites W2099062342 @default.
- W4308752107 cites W2099505694 @default.
- W4308752107 cites W2101749257 @default.
- W4308752107 cites W2111404068 @default.
- W4308752107 cites W2127862779 @default.
- W4308752107 cites W2128542677 @default.
- W4308752107 cites W2134979684 @default.
- W4308752107 cites W2149662085 @default.
- W4308752107 cites W2153747430 @default.
- W4308752107 cites W2160051211 @default.
- W4308752107 cites W2160466424 @default.
- W4308752107 cites W2163173465 @default.
- W4308752107 cites W2168143310 @default.
- W4308752107 cites W2168420784 @default.
- W4308752107 cites W2169373177 @default.
- W4308752107 cites W2257573908 @default.
- W4308752107 cites W2287840388 @default.
- W4308752107 cites W2294327742 @default.
- W4308752107 cites W2301244061 @default.
- W4308752107 cites W2321587450 @default.
- W4308752107 cites W2336828812 @default.
- W4308752107 cites W2522313999 @default.
- W4308752107 cites W2558046424 @default.
- W4308752107 cites W2573357293 @default.
- W4308752107 cites W2589482385 @default.
- W4308752107 cites W2597062310 @default.
- W4308752107 cites W2605233023 @default.
- W4308752107 cites W2605955768 @default.
- W4308752107 cites W2735132087 @default.
- W4308752107 cites W2736476343 @default.
- W4308752107 cites W2737083047 @default.
- W4308752107 cites W2737389832 @default.
- W4308752107 cites W2739511077 @default.
- W4308752107 cites W2741508285 @default.
- W4308752107 cites W2744743363 @default.
- W4308752107 cites W2750328162 @default.
- W4308752107 cites W2760942750 @default.
- W4308752107 cites W2763042654 @default.
- W4308752107 cites W2766003958 @default.
- W4308752107 cites W2766599608 @default.
- W4308752107 cites W2767593721 @default.
- W4308752107 cites W2782124401 @default.
- W4308752107 cites W2782183686 @default.
- W4308752107 cites W2782932615 @default.
- W4308752107 cites W2783339841 @default.
- W4308752107 cites W2790208381 @default.
- W4308752107 cites W2800773898 @default.
- W4308752107 cites W2804123836 @default.
- W4308752107 cites W2804568941 @default.
- W4308752107 cites W2858926507 @default.
- W4308752107 cites W2886498337 @default.
- W4308752107 cites W2895987324 @default.
- W4308752107 cites W2897700601 @default.
- W4308752107 cites W2904139947 @default.
- W4308752107 cites W2905437169 @default.
- W4308752107 cites W2912580313 @default.
- W4308752107 cites W2915043906 @default.
- W4308752107 cites W2929149171 @default.
- W4308752107 cites W2931798092 @default.
- W4308752107 cites W2936686072 @default.
- W4308752107 cites W2938206352 @default.
- W4308752107 cites W2947826965 @default.
- W4308752107 cites W2949633340 @default.
- W4308752107 cites W2950195808 @default.
- W4308752107 cites W2952845469 @default.
- W4308752107 cites W2959016616 @default.
- W4308752107 cites W2969111064 @default.
- W4308752107 cites W2969378520 @default.
- W4308752107 cites W2973160589 @default.
- W4308752107 cites W2979323908 @default.
- W4308752107 cites W2981137429 @default.
- W4308752107 cites W2983649157 @default.
- W4308752107 cites W2990393399 @default.
- W4308752107 cites W2999272357 @default.
- W4308752107 cites W3004480399 @default.
- W4308752107 cites W3006500278 @default.