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- W4308763313 abstract "To evaluate the effect of computed tomography (CT) tube voltage and CT density for CT-based attenuation correction (CTAC) on quantification of tracer uptake in single photon emission computed tomography (SPECT)/CT.A cylindrical phantom contained 7 cylinders with diameter of 30 mm. The central cylinder and background part were filled with 17 kBq/ml of 99mTc-pertechnetate solution. Of the remaining 6 cylinders, one cylinder was filled with water and 5 cylinders were filled with each own different concentration of K2HPO4 solution (120, 275, 450, 666, and 960 mg/cm3) to simulate different bone densities. The 6 cylinders also contained 99mTc-pertechnetate solution with the same radioactivity concentration (207 kBq/ml). CT scans were performed with 4 different tube voltages of 80, 100, 120, and 140 kVp for CTAC. The radioactivity concentration in the 6 cylinders were measured on the SPECT images processed with 4 different attenuation coefficient maps derived from each tube voltage of CT images.Compared with the water cylinder without K2HPO4 solution, the measured radioactivity of the highest density cylinder (K2HPO4 solution concentration: 960 mg/cm3) was found to be overestimated by 3.3 % and 4.3 %, respectively, when the tube voltage was 120 kVp and 140 kVp (p = 0.022). The use of low-tube voltage, such as 80 kVp, has improved the quantitative accuracy of bone SPECT/CT.SPECT quantitative evaluation of tracers in high-density objects tends to overestimate as tube voltage for CTAC increases. However, the overestimation in quantitative SPECT/CT evaluation in simulated bone area is less than 5% at most." @default.
- W4308763313 created "2022-11-15" @default.
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- W4308763313 date "2022-12-01" @default.
- W4308763313 modified "2023-10-18" @default.
- W4308763313 title "Impact of CT tube-voltage and bone density on the quantitative assessment of tracer uptake in Tc-99m bone SPECT/CT: A phantom study" @default.
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- W4308763313 doi "https://doi.org/10.1016/j.ejmp.2022.10.022" @default.
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