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- W4308770146 abstract "Microtubules are essential components of the cytoskeleton that allow bi-lateral neuronal transport. Correct regulation of these complex intracellular transport processes is central to neuronal function. However, despite major advancements in our knowledge, we still lack a complete understanding on how neuronal transport is regulated. Here, we provide further evidence for the importance of the highly conserved N-terminal H12-helix of α-tubulin. We show that a mutation in this region results in the mistargeting of axonal mitochondria in Caenorhabditis elegans , thereby establishing the importance of the H12-helix in regulating mitochondrial transport in neurons." @default.
- W4308770146 created "2022-11-15" @default.
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- W4308770146 date "2022-01-01" @default.
- W4308770146 modified "2023-10-18" @default.
- W4308770146 title "Mutation of the H12-helix of α-tubulin/MEC-12 disrupts the localization of neuronal mitochondria." @default.
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- W4308770146 doi "https://doi.org/10.17912/micropub.biology.000659" @default.
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