Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308770712> ?p ?o ?g. }
- W4308770712 endingPage "2429" @default.
- W4308770712 startingPage "2429" @default.
- W4308770712 abstract "Resistance to checkpoint-blockade treatments is a challenge in the clinic. Both primary and acquired resistance have become major obstacles, greatly limiting the long-lasting effects and wide application of blockade therapy. Many patients with metastatic melanoma eventually require further therapy. The absence of T-cell infiltration to the tumor site is a well-accepted contributor limiting immune checkpoint inhibitor efficacy. In this study, we combined intratumoral injection of plasmid IL-12 with electrotransfer and anti-PD-1 in metastatic B16F10 melanoma tumor model to increase tumor-infiltrating lymphocytes and improve therapeutic efficacy. We showed that effective anti-tumor responses required a subset of tumor-infiltrating CD8+ and CD4+ T cells. Additionally, the combination therapy induced higher MHC-I surface expression on tumor cells to hamper tumor cells escaping from immune recognition. Furthermore, we found that activating T cells by exposure to IL-12 resulted in tumors sensitized to anti-PD-1 treatment, suggesting a therapeutic strategy to improve responses to checkpoint blockade." @default.
- W4308770712 created "2022-11-15" @default.
- W4308770712 creator A5016231120 @default.
- W4308770712 creator A5036921744 @default.
- W4308770712 creator A5057362562 @default.
- W4308770712 creator A5088163334 @default.
- W4308770712 date "2022-11-10" @default.
- W4308770712 modified "2023-09-26" @default.
- W4308770712 title "Modification of the Tumor Microenvironment Enhances Anti-PD-1 Immunotherapy in Metastatic Melanoma" @default.
- W4308770712 cites W1567614169 @default.
- W4308770712 cites W1836115854 @default.
- W4308770712 cites W1883285104 @default.
- W4308770712 cites W1944707476 @default.
- W4308770712 cites W1972913617 @default.
- W4308770712 cites W1988803031 @default.
- W4308770712 cites W2013064448 @default.
- W4308770712 cites W2033740339 @default.
- W4308770712 cites W2037342985 @default.
- W4308770712 cites W2051236462 @default.
- W4308770712 cites W2057317645 @default.
- W4308770712 cites W2057822452 @default.
- W4308770712 cites W2067738057 @default.
- W4308770712 cites W2070059266 @default.
- W4308770712 cites W2074092467 @default.
- W4308770712 cites W2076337048 @default.
- W4308770712 cites W2092921437 @default.
- W4308770712 cites W2095242372 @default.
- W4308770712 cites W2099044540 @default.
- W4308770712 cites W2100510996 @default.
- W4308770712 cites W2122387392 @default.
- W4308770712 cites W2128799252 @default.
- W4308770712 cites W2133567701 @default.
- W4308770712 cites W2134756173 @default.
- W4308770712 cites W2136859769 @default.
- W4308770712 cites W2144122733 @default.
- W4308770712 cites W2153398168 @default.
- W4308770712 cites W2162543584 @default.
- W4308770712 cites W2165200432 @default.
- W4308770712 cites W2285621780 @default.
- W4308770712 cites W2315165762 @default.
- W4308770712 cites W2316005366 @default.
- W4308770712 cites W2333761664 @default.
- W4308770712 cites W2337923302 @default.
- W4308770712 cites W2554479252 @default.
- W4308770712 cites W2578528809 @default.
- W4308770712 cites W2607506177 @default.
- W4308770712 cites W2612431515 @default.
- W4308770712 cites W2758791715 @default.
- W4308770712 cites W2766430096 @default.
- W4308770712 cites W2767183168 @default.
- W4308770712 cites W2767533179 @default.
- W4308770712 cites W2781514432 @default.
- W4308770712 cites W2782007611 @default.
- W4308770712 cites W2785711875 @default.
- W4308770712 cites W2790362775 @default.
- W4308770712 cites W2796894486 @default.
- W4308770712 cites W2808898302 @default.
- W4308770712 cites W2889358860 @default.
- W4308770712 cites W2897222331 @default.
- W4308770712 cites W2898917472 @default.
- W4308770712 cites W2904909612 @default.
- W4308770712 cites W2914345456 @default.
- W4308770712 cites W2922416244 @default.
- W4308770712 cites W2954718550 @default.
- W4308770712 cites W2964607730 @default.
- W4308770712 cites W2971761467 @default.
- W4308770712 cites W2972560557 @default.
- W4308770712 cites W2972715430 @default.
- W4308770712 cites W2975736787 @default.
- W4308770712 cites W2996282268 @default.
- W4308770712 cites W3015068997 @default.
- W4308770712 cites W3015860015 @default.
- W4308770712 cites W3039384063 @default.
- W4308770712 cites W3039693333 @default.
- W4308770712 cites W3043756975 @default.
- W4308770712 cites W3046869151 @default.
- W4308770712 cites W3106005610 @default.
- W4308770712 cites W3131237227 @default.
- W4308770712 cites W3148581965 @default.
- W4308770712 cites W3161527971 @default.
- W4308770712 cites W3175114505 @default.
- W4308770712 cites W3179090427 @default.
- W4308770712 cites W3194570062 @default.
- W4308770712 cites W3200816639 @default.
- W4308770712 cites W3202417008 @default.
- W4308770712 cites W3212582257 @default.
- W4308770712 cites W4226087030 @default.
- W4308770712 cites W4313377153 @default.
- W4308770712 doi "https://doi.org/10.3390/pharmaceutics14112429" @default.
- W4308770712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36365247" @default.
- W4308770712 hasPublicationYear "2022" @default.
- W4308770712 type Work @default.
- W4308770712 citedByCount "0" @default.
- W4308770712 crossrefType "journal-article" @default.
- W4308770712 hasAuthorship W4308770712A5016231120 @default.
- W4308770712 hasAuthorship W4308770712A5036921744 @default.
- W4308770712 hasAuthorship W4308770712A5057362562 @default.
- W4308770712 hasAuthorship W4308770712A5088163334 @default.