Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308771121> ?p ?o ?g. }
- W4308771121 abstract "Abstract The hippocampus has been a focus of memory research since H.M’s surgery abolished his ability to form new memories, yet its mechanistic role in memory remains debated. Here, we identify a candidate memory mechanism: an anticipatory hippocampal “convergence state”, observed while awaiting valuable information, and which predicts subsequent learning. During fMRI, participants viewed trivia questions eliciting high or low curiosity, followed seconds later by its answer. We reasoned that encoding success requires a confluence of conditions, so that hippocampal states more conducive to memory formation should converge in state space. To operationalize convergence of neural states, we quantified the typicality of multivoxel patterns in the medial temporal lobes during anticipation and encoding of trivia answers. We found that the typicality of anticipatory hippocampal patterns increased during high curiosity. Crucially, anticipatory hippocampal pattern typicality increased with dopaminergic midbrain activation and uniquely accounted for the association between midbrain activation and subsequent recall. We propose that hippocampal convergence states may complete a cascade from motivation and midbrain activation to memory enhancement, and may be a general predictor of memory formation." @default.
- W4308771121 created "2022-11-15" @default.
- W4308771121 creator A5003787994 @default.
- W4308771121 creator A5023153459 @default.
- W4308771121 creator A5029513186 @default.
- W4308771121 creator A5042627400 @default.
- W4308771121 creator A5077754116 @default.
- W4308771121 creator A5084513979 @default.
- W4308771121 date "2022-11-07" @default.
- W4308771121 modified "2023-10-15" @default.
- W4308771121 title "Hippocampal convergence during anticipatory midbrain activation promotes subsequent memory formation" @default.
- W4308771121 cites W1617511168 @default.
- W4308771121 cites W1624847319 @default.
- W4308771121 cites W1743972096 @default.
- W4308771121 cites W1862369655 @default.
- W4308771121 cites W1868297237 @default.
- W4308771121 cites W1966647730 @default.
- W4308771121 cites W1975511495 @default.
- W4308771121 cites W1978323282 @default.
- W4308771121 cites W1978632440 @default.
- W4308771121 cites W1981518369 @default.
- W4308771121 cites W1982771150 @default.
- W4308771121 cites W1983851341 @default.
- W4308771121 cites W1986856036 @default.
- W4308771121 cites W1990287391 @default.
- W4308771121 cites W1991396817 @default.
- W4308771121 cites W1992431665 @default.
- W4308771121 cites W1995608662 @default.
- W4308771121 cites W1995807760 @default.
- W4308771121 cites W1997065612 @default.
- W4308771121 cites W2004985746 @default.
- W4308771121 cites W2008016900 @default.
- W4308771121 cites W2008440125 @default.
- W4308771121 cites W2014295524 @default.
- W4308771121 cites W2014814217 @default.
- W4308771121 cites W2016985810 @default.
- W4308771121 cites W2017814058 @default.
- W4308771121 cites W2025180344 @default.
- W4308771121 cites W2030492864 @default.
- W4308771121 cites W2033080466 @default.
- W4308771121 cites W2040079144 @default.
- W4308771121 cites W2058113871 @default.
- W4308771121 cites W2060013190 @default.
- W4308771121 cites W2060322330 @default.
- W4308771121 cites W2061337775 @default.
- W4308771121 cites W2080947435 @default.
- W4308771121 cites W2084262425 @default.
- W4308771121 cites W2086051064 @default.
- W4308771121 cites W2087364000 @default.
- W4308771121 cites W2089858495 @default.
- W4308771121 cites W2093307165 @default.
- W4308771121 cites W2097872145 @default.
- W4308771121 cites W2098036797 @default.
- W4308771121 cites W2100495570 @default.
- W4308771121 cites W2105031232 @default.
- W4308771121 cites W2105380935 @default.
- W4308771121 cites W2107669731 @default.
- W4308771121 cites W2109738307 @default.
- W4308771121 cites W2111873046 @default.
- W4308771121 cites W2119051448 @default.
- W4308771121 cites W2120294545 @default.
- W4308771121 cites W2121007598 @default.
- W4308771121 cites W2126561217 @default.
- W4308771121 cites W2127820682 @default.
- W4308771121 cites W2129651491 @default.
- W4308771121 cites W2141137228 @default.
- W4308771121 cites W2142281591 @default.
- W4308771121 cites W2144380923 @default.
- W4308771121 cites W2148464817 @default.
- W4308771121 cites W2148601705 @default.
- W4308771121 cites W2150299732 @default.
- W4308771121 cites W2152372327 @default.
- W4308771121 cites W2153591523 @default.
- W4308771121 cites W2156030074 @default.
- W4308771121 cites W2159010963 @default.
- W4308771121 cites W2166389509 @default.
- W4308771121 cites W2219434763 @default.
- W4308771121 cites W2221058550 @default.
- W4308771121 cites W2228573 @default.
- W4308771121 cites W2239044001 @default.
- W4308771121 cites W2257753958 @default.
- W4308771121 cites W2262462128 @default.
- W4308771121 cites W2313800377 @default.
- W4308771121 cites W2418977803 @default.
- W4308771121 cites W2463714666 @default.
- W4308771121 cites W2508644210 @default.
- W4308771121 cites W2522032375 @default.
- W4308771121 cites W2553316040 @default.
- W4308771121 cites W2554443566 @default.
- W4308771121 cites W2560366665 @default.
- W4308771121 cites W2560490590 @default.
- W4308771121 cites W2584574251 @default.
- W4308771121 cites W2592394607 @default.
- W4308771121 cites W2592616773 @default.
- W4308771121 cites W2749612575 @default.
- W4308771121 cites W2767366333 @default.
- W4308771121 cites W2808384964 @default.
- W4308771121 cites W2809440348 @default.
- W4308771121 cites W2894618011 @default.
- W4308771121 cites W2911430788 @default.