FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308771830> ?p ?o ?g. }

• W4308771830 endingPage "e1010487" @default.
• W4308771830 startingPage "e1010487" @default.
• W4308771830 abstract "Proper timing of rhythmic locomotor behavior is the consequence of integrating environmental conditions and internal time dictated by the circadian clock. Rhythmic environmental input like daily light and temperature changes (called Zeitgeber) reset the molecular clock and entrain it to the environmental time zone the organism lives in. Furthermore, depending on the absolute temperature or light intensity, flies exhibit their main locomotor activity at different times of day, i.e., environmental input not only entrains the circadian clock but also determines the phase of a certain behavior. To understand how the brain clock can distinguish between (or integrate) an entraining Zeitgeber and environmental effects on activity phase, we attempted to entrain the clock with a Zeitgeber different from the environmental input used for phasing the behavior. 150 clock neurons in the Drosophila melanogaster brain control different aspects of the daily activity rhythms and are organized in various clusters. During regular 12 h light: 12 h dark cycles at constant mild temperature (LD 25°C, LD being the Zeitgeber), so called morning oscillator (MO) neurons control the increase of locomotor activity just before lights-on, while evening oscillator (EO) neurons regulate the activity increase at the end of the day, a few hours before lights-off. Here, using 12 h: 12 h 25°C:16°C temperature cycles as Zeitgeber, we attempted to look at the impact of light on phasing locomotor behavior. While in constant light and 25°C:16°C temperature cycles (LLTC), flies show an unimodal locomotor activity peak in the evening, during the same temperature cycle, but in the absence of light (DDTC), the phase of the activity peak is shifted to the morning. Here, we show that the EO is necessary for synchronized behavior in LLTC but not for entraining the molecular clock of the other clock neuronal groups, while the MO controls synchronized morning activity in DDTC. Interestingly, our data suggest that the influence of the EO on the synchronization increases depending on the length of the photoperiod (constant light vs 12 h of light). Hence, our results show that effects of different environmental cues on clock entrainment and activity phase can be separated, allowing to decipher their integration by the circadian clock." @default.
• W4308771830 created "2022-11-15" @default.
• W4308771830 creator A5073367842 @default.
• W4308771830 creator A5075986322 @default.
• W4308771830 creator A5077002391 @default.
• W4308771830 creator A5078675775 @default.
• W4308771830 date "2022-11-11" @default.
• W4308771830 modified "2023-09-25" @default.
• W4308771830 title "Light triggers a network switch between circadian morning and evening oscillators controlling behaviour during daily temperature cycles" @default.
• W4308771830 cites W1964204115 @default.
• W4308771830 cites W1964557069 @default.
• W4308771830 cites W1968548713 @default.
• W4308771830 cites W1979388618 @default.
• W4308771830 cites W1980205405 @default.
• W4308771830 cites W1984673374 @default.
• W4308771830 cites W1987956257 @default.
• W4308771830 cites W1998371106 @default.
• W4308771830 cites W2001140892 @default.
• W4308771830 cites W2002074937 @default.
• W4308771830 cites W2026006020 @default.
• W4308771830 cites W2026030226 @default.
• W4308771830 cites W2031483444 @default.
• W4308771830 cites W2032346714 @default.
• W4308771830 cites W2049253094 @default.
• W4308771830 cites W2051625615 @default.
• W4308771830 cites W2052915113 @default.
• W4308771830 cites W2060215515 @default.
• W4308771830 cites W2069102506 @default.
• W4308771830 cites W2071250433 @default.
• W4308771830 cites W2076696166 @default.
• W4308771830 cites W2077949863 @default.
• W4308771830 cites W2091287207 @default.
• W4308771830 cites W2103889336 @default.
• W4308771830 cites W2108055061 @default.
• W4308771830 cites W2110659224 @default.
• W4308771830 cites W2113526393 @default.
• W4308771830 cites W2132434008 @default.
• W4308771830 cites W2137798105 @default.
• W4308771830 cites W2137867563 @default.
• W4308771830 cites W2139288552 @default.
• W4308771830 cites W2146535211 @default.
• W4308771830 cites W2160510036 @default.
• W4308771830 cites W2165139129 @default.
• W4308771830 cites W2169137344 @default.
• W4308771830 cites W2177863086 @default.
• W4308771830 cites W2209333882 @default.
• W4308771830 cites W2276547531 @default.
• W4308771830 cites W2413247830 @default.
• W4308771830 cites W2577183914 @default.
• W4308771830 cites W2617723761 @default.
• W4308771830 cites W2743543114 @default.
• W4308771830 cites W2758288252 @default.
• W4308771830 cites W2788464253 @default.
• W4308771830 cites W2792035889 @default.
• W4308771830 cites W2801508417 @default.
• W4308771830 cites W2803491895 @default.
• W4308771830 cites W2807840790 @default.
• W4308771830 cites W2952837230 @default.
• W4308771830 cites W2953339796 @default.
• W4308771830 cites W2954543098 @default.
• W4308771830 cites W2995579772 @default.
• W4308771830 cites W3027405662 @default.
• W4308771830 cites W3126413976 @default.
• W4308771830 cites W4226162610 @default.
• W4308771830 cites W4236619403 @default.
• W4308771830 cites W4292110700 @default.
• W4308771830 doi "https://doi.org/10.1371/journal.pgen.1010487" @default.
• W4308771830 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36367867" @default.
• W4308771830 hasPublicationYear "2022" @default.
• W4308771830 type Work @default.
• W4308771830 citedByCount "1" @default.
• W4308771830 countsByYear W43087718302023 @default.
• W4308771830 crossrefType "journal-article" @default.
• W4308771830 hasAuthorship W4308771830A5073367842 @default.
• W4308771830 hasAuthorship W4308771830A5075986322 @default.
• W4308771830 hasAuthorship W4308771830A5077002391 @default.
• W4308771830 hasAuthorship W4308771830A5078675775 @default.
• W4308771830 hasBestOaLocation W43087718301 @default.
• W4308771830 hasConcept C121332964 @default.
• W4308771830 hasConcept C121446783 @default.
• W4308771830 hasConcept C126322002 @default.
• W4308771830 hasConcept C1276947 @default.
• W4308771830 hasConcept C134018914 @default.
• W4308771830 hasConcept C135343436 @default.
• W4308771830 hasConcept C139992725 @default.
• W4308771830 hasConcept C169760540 @default.
• W4308771830 hasConcept C187765855 @default.
• W4308771830 hasConcept C19720800 @default.
• W4308771830 hasConcept C21786239 @default.
• W4308771830 hasConcept C2776476923 @default.
• W4308771830 hasConcept C2993436365 @default.
• W4308771830 hasConcept C38606739 @default.
• W4308771830 hasConcept C59822182 @default.
• W4308771830 hasConcept C71924100 @default.
• W4308771830 hasConcept C86803240 @default.
• W4308771830 hasConceptScore W4308771830C121332964 @default.
• W4308771830 hasConceptScore W4308771830C121446783 @default.
• W4308771830 hasConceptScore W4308771830C126322002 @default.

• next