Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308772947> ?p ?o ?g. }
- W4308772947 endingPage "1572" @default.
- W4308772947 startingPage "1560" @default.
- W4308772947 abstract "Variation in the blood metabolome is intimately related to human health. However, few details are known about the interplay between genetics and the microbiome in explaining this variation on a metabolite-by-metabolite level. Here, we perform analyses of variance for each of 930 blood metabolites robustly detected across a cohort of 1,569 individuals with paired genomic and microbiome data while controlling for a number of relevant covariates. We find that 595 (64%) of these blood metabolites are significantly associated with either host genetics or the gut microbiome, with 69% of these associations driven solely by the microbiome, 15% driven solely by genetics and 16% under hybrid genome-microbiome control. Additionally, interaction effects, where a metabolite-microbe association is specific to a particular genetic background, are quite common, albeit with modest effect sizes. This knowledge will help to guide targeted interventions designed to alter the composition of the human blood metabolome." @default.
- W4308772947 created "2022-11-15" @default.
- W4308772947 creator A5004117093 @default.
- W4308772947 creator A5035252203 @default.
- W4308772947 creator A5041101241 @default.
- W4308772947 creator A5042357313 @default.
- W4308772947 creator A5047359909 @default.
- W4308772947 creator A5047843839 @default.
- W4308772947 creator A5058043043 @default.
- W4308772947 creator A5064118261 @default.
- W4308772947 creator A5085306431 @default.
- W4308772947 date "2022-11-10" @default.
- W4308772947 modified "2023-10-16" @default.
- W4308772947 title "Genome–microbiome interplay provides insight into the determinants of the human blood metabolome" @default.
- W4308772947 cites W1554193366 @default.
- W4308772947 cites W1965809997 @default.
- W4308772947 cites W1969219820 @default.
- W4308772947 cites W1971151747 @default.
- W4308772947 cites W1979115298 @default.
- W4308772947 cites W1998977949 @default.
- W4308772947 cites W2008761626 @default.
- W4308772947 cites W2011587397 @default.
- W4308772947 cites W2012034410 @default.
- W4308772947 cites W2012490955 @default.
- W4308772947 cites W2026210437 @default.
- W4308772947 cites W2042363106 @default.
- W4308772947 cites W2042699357 @default.
- W4308772947 cites W2049169935 @default.
- W4308772947 cites W2049506766 @default.
- W4308772947 cites W2065865092 @default.
- W4308772947 cites W2088941906 @default.
- W4308772947 cites W2094290879 @default.
- W4308772947 cites W2099673318 @default.
- W4308772947 cites W2108195113 @default.
- W4308772947 cites W2125784987 @default.
- W4308772947 cites W2155897723 @default.
- W4308772947 cites W2158353135 @default.
- W4308772947 cites W2159146649 @default.
- W4308772947 cites W2162904770 @default.
- W4308772947 cites W2164339823 @default.
- W4308772947 cites W2168215272 @default.
- W4308772947 cites W2231185426 @default.
- W4308772947 cites W2401404581 @default.
- W4308772947 cites W2534785935 @default.
- W4308772947 cites W2587127477 @default.
- W4308772947 cites W2607135274 @default.
- W4308772947 cites W2765954021 @default.
- W4308772947 cites W2766426644 @default.
- W4308772947 cites W2787902098 @default.
- W4308772947 cites W2790838642 @default.
- W4308772947 cites W2809051650 @default.
- W4308772947 cites W2913928305 @default.
- W4308772947 cites W2942628179 @default.
- W4308772947 cites W2955961495 @default.
- W4308772947 cites W2970482505 @default.
- W4308772947 cites W2972177532 @default.
- W4308772947 cites W2980473293 @default.
- W4308772947 cites W2981562683 @default.
- W4308772947 cites W2991212521 @default.
- W4308772947 cites W3003518864 @default.
- W4308772947 cites W3009803243 @default.
- W4308772947 cites W3024651515 @default.
- W4308772947 cites W3035004775 @default.
- W4308772947 cites W3101637373 @default.
- W4308772947 cites W3104088357 @default.
- W4308772947 cites W3112849870 @default.
- W4308772947 cites W3142445645 @default.
- W4308772947 cites W3161269667 @default.
- W4308772947 cites W4200239440 @default.
- W4308772947 cites W4206806868 @default.
- W4308772947 cites W4236533258 @default.
- W4308772947 cites W4249791806 @default.
- W4308772947 cites W4296833397 @default.
- W4308772947 doi "https://doi.org/10.1038/s42255-022-00670-1" @default.
- W4308772947 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36357685" @default.
- W4308772947 hasPublicationYear "2022" @default.
- W4308772947 type Work @default.
- W4308772947 citedByCount "14" @default.
- W4308772947 countsByYear W43087729472023 @default.
- W4308772947 crossrefType "journal-article" @default.
- W4308772947 hasAuthorship W4308772947A5004117093 @default.
- W4308772947 hasAuthorship W4308772947A5035252203 @default.
- W4308772947 hasAuthorship W4308772947A5041101241 @default.
- W4308772947 hasAuthorship W4308772947A5042357313 @default.
- W4308772947 hasAuthorship W4308772947A5047359909 @default.
- W4308772947 hasAuthorship W4308772947A5047843839 @default.
- W4308772947 hasAuthorship W4308772947A5058043043 @default.
- W4308772947 hasAuthorship W4308772947A5064118261 @default.
- W4308772947 hasAuthorship W4308772947A5085306431 @default.
- W4308772947 hasBestOaLocation W43087729472 @default.
- W4308772947 hasConcept C104317684 @default.
- W4308772947 hasConcept C106208931 @default.
- W4308772947 hasConcept C135763542 @default.
- W4308772947 hasConcept C135870905 @default.
- W4308772947 hasConcept C141231307 @default.
- W4308772947 hasConcept C143121216 @default.
- W4308772947 hasConcept C153209595 @default.
- W4308772947 hasConcept C21565614 @default.