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- W4308773029 endingPage "112" @default.
- W4308773029 startingPage "101" @default.
- W4308773029 abstract "Merkel cell carcinoma (MCC) is a rare, highly aggressive cutaneous neuroendocrine carcinoma. Controversy exists regarding optimal management of MCC as high-quality randomized studies and clinical trials are limited, and physicians are bound to interpret highly heterogeneous, retrospective literature in their clinical practice. Furthermore, the rising incidence and notably poor prognosis of MCC urges the establishment of best practices for optimal management of the primary tumor and its metastases. Herein, we summarized the relevant evidence and provided an algorithm for decision-making in MCC management based on the latest 2021 National Comprehensive Cancer Network guidelines. Additionally, we report current active MCC clinical trials in the United States. The initial management of MCC is dependent upon the pathology of the primary tumor and presence of metastatic disease. Patients with no clinical evidence of regional lymph node involvement generally require sentinel node biopsy (SLNB) while clinically node-positive patients should undergo fine needle aspiration (FNA) or core biopsy and full imaging workup. If SLNB or FNA/core biopsy are positive, a multidisciplinary team should be assembled to discuss if additional node dissection or adjuvant therapy is necessary. Wide local excision is optimal for primary tumor management and SLNB remains the preferred staging and predictive tool in MCC. The management of MCC has progressively improved in the last decade, particularly due to the establishment of immunotherapy as a new treatment option in advanced MCC. Ongoing trials and prospective studies are needed to further establish the best practices for MCC management." @default.
- W4308773029 created "2022-11-15" @default.
- W4308773029 creator A5000221682 @default.
- W4308773029 creator A5037484719 @default.
- W4308773029 creator A5059732061 @default.
- W4308773029 creator A5060942905 @default.
- W4308773029 creator A5066119888 @default.
- W4308773029 creator A5085211151 @default.
- W4308773029 creator A5087859996 @default.
- W4308773029 date "2022-11-11" @default.
- W4308773029 modified "2023-09-25" @default.
- W4308773029 title "Best practices in surgical and nonsurgical management of head and neck Merkel cell carcinoma: An update" @default.
- W4308773029 cites W1486250337 @default.
- W4308773029 cites W1539889266 @default.
- W4308773029 cites W1601579599 @default.
- W4308773029 cites W1909452331 @default.
- W4308773029 cites W1949115090 @default.
- W4308773029 cites W1963598077 @default.
- W4308773029 cites W1987142281 @default.
- W4308773029 cites W1993412014 @default.
- W4308773029 cites W1994645123 @default.
- W4308773029 cites W2002007665 @default.
- W4308773029 cites W2003694564 @default.
- W4308773029 cites W2018050275 @default.
- W4308773029 cites W2030145129 @default.
- W4308773029 cites W2032276273 @default.
- W4308773029 cites W2036619670 @default.
- W4308773029 cites W2064572545 @default.
- W4308773029 cites W2070825440 @default.
- W4308773029 cites W2080285877 @default.
- W4308773029 cites W2085487956 @default.
- W4308773029 cites W2114997863 @default.
- W4308773029 cites W2115410690 @default.
- W4308773029 cites W2118072648 @default.
- W4308773029 cites W2126020257 @default.
- W4308773029 cites W2131182971 @default.
- W4308773029 cites W2132134072 @default.
- W4308773029 cites W2132571078 @default.
- W4308773029 cites W2134165280 @default.
- W4308773029 cites W2136132775 @default.
- W4308773029 cites W2143264082 @default.
- W4308773029 cites W2165920085 @default.
- W4308773029 cites W2171480930 @default.
- W4308773029 cites W2193255092 @default.
- W4308773029 cites W2296591944 @default.
- W4308773029 cites W2296709401 @default.
- W4308773029 cites W2324130189 @default.
- W4308773029 cites W2339890238 @default.
- W4308773029 cites W2407443857 @default.
- W4308773029 cites W2468834238 @default.
- W4308773029 cites W2471771330 @default.
- W4308773029 cites W2498543837 @default.
- W4308773029 cites W2500892204 @default.
- W4308773029 cites W2510686645 @default.
- W4308773029 cites W2560846260 @default.
- W4308773029 cites W2573152477 @default.
- W4308773029 cites W2594188900 @default.
- W4308773029 cites W2602946883 @default.
- W4308773029 cites W2615736857 @default.
- W4308773029 cites W2752227448 @default.
- W4308773029 cites W2760692887 @default.
- W4308773029 cites W2765591968 @default.
- W4308773029 cites W2765847865 @default.
- W4308773029 cites W2766831098 @default.
- W4308773029 cites W2774704267 @default.
- W4308773029 cites W2783234388 @default.
- W4308773029 cites W2785800563 @default.
- W4308773029 cites W2797309423 @default.
- W4308773029 cites W2808701153 @default.
- W4308773029 cites W2883682996 @default.
- W4308773029 cites W2884814566 @default.
- W4308773029 cites W2885153281 @default.
- W4308773029 cites W2890527521 @default.
- W4308773029 cites W2916208266 @default.
- W4308773029 cites W2919839730 @default.
- W4308773029 cites W2922558646 @default.
- W4308773029 cites W2940759533 @default.
- W4308773029 cites W2959607708 @default.
- W4308773029 cites W2991178915 @default.
- W4308773029 cites W3003310139 @default.
- W4308773029 cites W3007959720 @default.
- W4308773029 cites W3024881937 @default.
- W4308773029 cites W3043967237 @default.
- W4308773029 cites W3045376278 @default.
- W4308773029 cites W3047989122 @default.
- W4308773029 cites W3112334180 @default.
- W4308773029 cites W3120517966 @default.
- W4308773029 cites W3123790200 @default.
- W4308773029 cites W3129945809 @default.
- W4308773029 cites W3137564649 @default.
- W4308773029 cites W3153882210 @default.
- W4308773029 cites W3198705523 @default.
- W4308773029 cites W3210351033 @default.
- W4308773029 cites W4206979434 @default.
- W4308773029 cites W4213413276 @default.
- W4308773029 cites W4221018208 @default.
- W4308773029 cites W4283118026 @default.
- W4308773029 cites W4284667206 @default.