Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308773334> ?p ?o ?g. }
- W4308773334 endingPage "61" @default.
- W4308773334 startingPage "50" @default.
- W4308773334 abstract "The Red blood cell (RBC) storage lesion results in decreased circulation and function of transfused RBCs. Elevated oxidant stress and impaired energy metabolism are a hallmark of the storage lesion in both human and murine RBCs. Although human studies don't suffer concerns that findings may not translate, they do suffer from genetic and environmental variability amongst subjects. Murine models can control for genetics, environment, and much interventional experimentation can be carried out in mice that is neither technically feasible nor ethical in humans. However, murine models are only useful to the extent that they have similar biology to humans. Hypoxic storage has been shown to mitigate the storage lesion in human RBCs, but has not been investigated in mice.RBCs from a C57BL6/J mouse strain were stored under normoxic (untreated) or hypoxic conditions (SO2 ~ 26%) for 1h, 7 and 12 days. Samples were tested for metabolomics at steady state, tracing experiments with 1,2,3-13C3-glucose, proteomics and end of storage post transfusion recovery.Hypoxic storage improved post-transfusion recovery and energy metabolism, including increased steady state and 13C3-labeled metabolites from glycolysis, high energy purines (adenosine triphosphate) and 2,3-diphospholgycerate. Hypoxic storage promoted glutaminolysis, increased glutathione pools, and was accompanied by elevation in the levels of free fatty acids and acyl-carnitines.This study isolates hypoxia, as a single independent variable, and shows similar effects as seen in human studies. These findings also demonstrate the translatability of murine models for hypoxic RBC storage and provide a pre-clinical platform for ongoing study." @default.
- W4308773334 created "2022-11-15" @default.
- W4308773334 creator A5000879710 @default.
- W4308773334 creator A5016440099 @default.
- W4308773334 creator A5041867277 @default.
- W4308773334 creator A5045175167 @default.
- W4308773334 creator A5053642769 @default.
- W4308773334 creator A5079802969 @default.
- W4308773334 creator A5089380647 @default.
- W4308773334 date "2023-01-01" @default.
- W4308773334 modified "2023-10-12" @default.
- W4308773334 title "Hypoxic storage of murine red blood cells improves energy metabolism and post-transfusion recoveries." @default.
- W4308773334 cites W104677424 @default.
- W4308773334 cites W1484078749 @default.
- W4308773334 cites W1501969485 @default.
- W4308773334 cites W1547764162 @default.
- W4308773334 cites W1596838762 @default.
- W4308773334 cites W1661767063 @default.
- W4308773334 cites W1981112659 @default.
- W4308773334 cites W2005252355 @default.
- W4308773334 cites W2010156173 @default.
- W4308773334 cites W2013291317 @default.
- W4308773334 cites W2067520432 @default.
- W4308773334 cites W2078137514 @default.
- W4308773334 cites W2086534621 @default.
- W4308773334 cites W2142862062 @default.
- W4308773334 cites W2149917889 @default.
- W4308773334 cites W2150319414 @default.
- W4308773334 cites W2194318288 @default.
- W4308773334 cites W2336431840 @default.
- W4308773334 cites W2341784617 @default.
- W4308773334 cites W2461866271 @default.
- W4308773334 cites W2466448487 @default.
- W4308773334 cites W2515863781 @default.
- W4308773334 cites W2523108916 @default.
- W4308773334 cites W2548952244 @default.
- W4308773334 cites W2587940603 @default.
- W4308773334 cites W2668200717 @default.
- W4308773334 cites W2765876921 @default.
- W4308773334 cites W2766399257 @default.
- W4308773334 cites W2800057211 @default.
- W4308773334 cites W2897068051 @default.
- W4308773334 cites W2898376167 @default.
- W4308773334 cites W2938328634 @default.
- W4308773334 cites W2946052571 @default.
- W4308773334 cites W2946569365 @default.
- W4308773334 cites W2965789264 @default.
- W4308773334 cites W2971532346 @default.
- W4308773334 cites W2988667613 @default.
- W4308773334 cites W3007643696 @default.
- W4308773334 cites W3009592638 @default.
- W4308773334 cites W3015129246 @default.
- W4308773334 cites W3021841489 @default.
- W4308773334 cites W3023543087 @default.
- W4308773334 cites W3025754506 @default.
- W4308773334 cites W3086037264 @default.
- W4308773334 cites W3094906604 @default.
- W4308773334 cites W3108523702 @default.
- W4308773334 cites W3118232987 @default.
- W4308773334 cites W3143155190 @default.
- W4308773334 cites W3157833237 @default.
- W4308773334 cites W3159995035 @default.
- W4308773334 cites W3161401306 @default.
- W4308773334 cites W3198267810 @default.
- W4308773334 cites W3212616106 @default.
- W4308773334 cites W4210652825 @default.
- W4308773334 cites W4220941514 @default.
- W4308773334 cites W4224806119 @default.
- W4308773334 doi "https://doi.org/10.2450/2022.0172-22" @default.
- W4308773334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36346885" @default.
- W4308773334 hasPublicationYear "2023" @default.
- W4308773334 type Work @default.
- W4308773334 citedByCount "4" @default.
- W4308773334 countsByYear W43087733342023 @default.
- W4308773334 crossrefType "journal-article" @default.
- W4308773334 hasAuthorship W4308773334A5000879710 @default.
- W4308773334 hasAuthorship W4308773334A5016440099 @default.
- W4308773334 hasAuthorship W4308773334A5041867277 @default.
- W4308773334 hasAuthorship W4308773334A5045175167 @default.
- W4308773334 hasAuthorship W4308773334A5053642769 @default.
- W4308773334 hasAuthorship W4308773334A5079802969 @default.
- W4308773334 hasAuthorship W4308773334A5089380647 @default.
- W4308773334 hasConcept C126322002 @default.
- W4308773334 hasConcept C142724271 @default.
- W4308773334 hasConcept C178790620 @default.
- W4308773334 hasConcept C185592680 @default.
- W4308773334 hasConcept C20251656 @default.
- W4308773334 hasConcept C2778160063 @default.
- W4308773334 hasConcept C2779564974 @default.
- W4308773334 hasConcept C2781156865 @default.
- W4308773334 hasConcept C540031477 @default.
- W4308773334 hasConcept C55493867 @default.
- W4308773334 hasConcept C57600042 @default.
- W4308773334 hasConcept C62231903 @default.
- W4308773334 hasConcept C71924100 @default.
- W4308773334 hasConcept C7836513 @default.
- W4308773334 hasConcept C86803240 @default.
- W4308773334 hasConceptScore W4308773334C126322002 @default.