Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308774966> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W4308774966 endingPage "192" @default.
- W4308774966 startingPage "186" @default.
- W4308774966 abstract "Abstract Introduction Acquired hemophilia A (AHA) is a rare autoimmune hemorrhagic disease occurring in several underlying conditions. Drug‐associated AHA (D‐AHA) is poorly addressed nowadays. Aim This work aims to identify and characterize which drugs are associated with AHA using the WHO global database of reported potential effects of medicinal products (VigiBase). Methods First, we realized a disproportionality analysis using the information component (IC) to identify D‐AHA in VigiBase. IC compares observed‐ and expected‐values in order to find associations between drugs and adverse drug reactions (ADRs) using disproportionate Bayesian reporting. IC 025 is the lower end of a 95% credibility interval for the IC. Then, we collected cases of drugs significantly associated with AHA from July 2004 to November 2021. Results 14 drugs with IC 025 > 0 were identified representing a total of 185 cases. D‐AHA occurred more frequently in men (59%) than women (41%). The median (min–max) age at onset was 75 years (8–98). The median [Q1–Q3] time to onset of D‐AHA from the start of the suspected drug was 30 days [9.5–73.75] and 10% of cases resulted in a fatality. The drugs associated with the highest IC 025 (IC 025 > 2) were Clopidogrel, Alemtuzumab, Omalizumab. This study retrieved for the first time three usually used drugs (3/14) that exhibit a significant pharmacovigilance signal for D‐AHA. Conclusion This worldwide pharmaco‐epidemiologic study updates the list of the drugs associated with AHA. The clinician should be aware of these possible severe ADR, which might require larger epidemiological and pathophysiologic studies." @default.
- W4308774966 created "2022-11-15" @default.
- W4308774966 creator A5006955984 @default.
- W4308774966 creator A5008780715 @default.
- W4308774966 creator A5055267294 @default.
- W4308774966 creator A5057334569 @default.
- W4308774966 creator A5058679231 @default.
- W4308774966 creator A5067055109 @default.
- W4308774966 creator A5082323092 @default.
- W4308774966 date "2022-11-11" @default.
- W4308774966 modified "2023-10-17" @default.
- W4308774966 title "Drug‐associated acquired hemophilia A: an analysis based on 185 cases from the WHO pharmacovigilance database" @default.
- W4308774966 cites W1576323218 @default.
- W4308774966 cites W1792313494 @default.
- W4308774966 cites W1997799955 @default.
- W4308774966 cites W1999701018 @default.
- W4308774966 cites W2004147651 @default.
- W4308774966 cites W2014493375 @default.
- W4308774966 cites W2015487160 @default.
- W4308774966 cites W2019513002 @default.
- W4308774966 cites W2025524023 @default.
- W4308774966 cites W2031168191 @default.
- W4308774966 cites W2043607649 @default.
- W4308774966 cites W2066568000 @default.
- W4308774966 cites W2166633925 @default.
- W4308774966 cites W2167186282 @default.
- W4308774966 cites W2574778880 @default.
- W4308774966 cites W2611005000 @default.
- W4308774966 cites W2623419592 @default.
- W4308774966 cites W2990841626 @default.
- W4308774966 cites W3094956147 @default.
- W4308774966 cites W3131011903 @default.
- W4308774966 cites W3139666310 @default.
- W4308774966 cites W3177780298 @default.
- W4308774966 cites W4210652145 @default.
- W4308774966 cites W4288052684 @default.
- W4308774966 doi "https://doi.org/10.1111/hae.14692" @default.
- W4308774966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36367755" @default.
- W4308774966 hasPublicationYear "2022" @default.
- W4308774966 type Work @default.
- W4308774966 citedByCount "1" @default.
- W4308774966 countsByYear W43087749662023 @default.
- W4308774966 crossrefType "journal-article" @default.
- W4308774966 hasAuthorship W4308774966A5006955984 @default.
- W4308774966 hasAuthorship W4308774966A5008780715 @default.
- W4308774966 hasAuthorship W4308774966A5055267294 @default.
- W4308774966 hasAuthorship W4308774966A5057334569 @default.
- W4308774966 hasAuthorship W4308774966A5058679231 @default.
- W4308774966 hasAuthorship W4308774966A5067055109 @default.
- W4308774966 hasAuthorship W4308774966A5082323092 @default.
- W4308774966 hasConcept C126322002 @default.
- W4308774966 hasConcept C187212893 @default.
- W4308774966 hasConcept C197934379 @default.
- W4308774966 hasConcept C2780035454 @default.
- W4308774966 hasConcept C41008148 @default.
- W4308774966 hasConcept C57658597 @default.
- W4308774966 hasConcept C71924100 @default.
- W4308774966 hasConcept C77088390 @default.
- W4308774966 hasConcept C98274493 @default.
- W4308774966 hasConceptScore W4308774966C126322002 @default.
- W4308774966 hasConceptScore W4308774966C187212893 @default.
- W4308774966 hasConceptScore W4308774966C197934379 @default.
- W4308774966 hasConceptScore W4308774966C2780035454 @default.
- W4308774966 hasConceptScore W4308774966C41008148 @default.
- W4308774966 hasConceptScore W4308774966C57658597 @default.
- W4308774966 hasConceptScore W4308774966C71924100 @default.
- W4308774966 hasConceptScore W4308774966C77088390 @default.
- W4308774966 hasConceptScore W4308774966C98274493 @default.
- W4308774966 hasIssue "1" @default.
- W4308774966 hasLocation W43087749661 @default.
- W4308774966 hasLocation W43087749662 @default.
- W4308774966 hasOpenAccess W4308774966 @default.
- W4308774966 hasPrimaryLocation W43087749661 @default.
- W4308774966 hasRelatedWork W2066240751 @default.
- W4308774966 hasRelatedWork W2094484004 @default.
- W4308774966 hasRelatedWork W2181320814 @default.
- W4308774966 hasRelatedWork W2328148312 @default.
- W4308774966 hasRelatedWork W2719570687 @default.
- W4308774966 hasRelatedWork W2894377005 @default.
- W4308774966 hasRelatedWork W2898439368 @default.
- W4308774966 hasRelatedWork W3105953293 @default.
- W4308774966 hasRelatedWork W3120767282 @default.
- W4308774966 hasRelatedWork W3128299827 @default.
- W4308774966 hasVolume "29" @default.
- W4308774966 isParatext "false" @default.
- W4308774966 isRetracted "false" @default.
- W4308774966 workType "article" @default.